Characteristics and outcome of varicella-zoster virus central nervous system infections in adults.
Encephalitis
Meningitis
Prognosis
Varicella-zoster virus
Journal
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
ISSN: 1435-4373
Titre abrégé: Eur J Clin Microbiol Infect Dis
Pays: Germany
ID NLM: 8804297
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
12
11
2020
accepted:
02
04
2021
pubmed:
29
4
2021
medline:
24
12
2021
entrez:
28
4
2021
Statut:
ppublish
Résumé
We conducted an observational retrospective study of all adults hospitalized for documented varicella-zoster virus (VZV) meningitis or encephalitis during years 2000-2015 in one referral centre. Thirty-six patients (21 males, 15 females) were included, with meningitis (n = 21), or meningoencephalitis (n = 15). Median age was 51 years [interquartile range, 35-76], and 6 patients (17%) were immunocompromised. Aciclovir was started in 32 patients (89%), with a median dose of 11 mg/kg/8 h [10-15]. No patient died, but 12 (33%) had neurological sequelae at discharge. Age was the only variable associated with adverse outcome (OR 1.98 [1.17-3.35] per 10-year increment, P = 0.011).
Identifiants
pubmed: 33907935
doi: 10.1007/s10096-021-04245-y
pii: 10.1007/s10096-021-04245-y
doi:
Substances chimiques
Antiviral Agents
0
Acyclovir
X4HES1O11F
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
2437-2442Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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