The association between high risk of sleep apnea, comorbidities, and risk of COVID-19: a population-based international harmonized study.

Adult COVID-19 / diagnosis COVID-19 Testing / statistics & numerical data Comorbidity Cross-Sectional Studies Depression / epidemiology Diabetes Mellitus, Type 2 / epidemiology Female Health Status Humans Male Middle Aged Prevalence Risk Factors Sex Factors Sleep Apnea, Obstructive / diagnosis Snoring / epidemiology
COVID-19 Depression Diabetes Obstructive sleep apnea STOP questionnaire

Journal

Sleep & breathing = Schlaf & Atmung
ISSN: 1522-1709
Titre abrégé: Sleep Breath
Pays: Germany
ID NLM: 9804161

Informations de publication

Date de publication:
06 2021
Historique:
received: 27 02 2021
accepted: 02 04 2021
revised: 31 03 2021
pubmed: 29 4 2021
medline: 29 6 2021
entrez: 28 4 2021
Statut: ppublish

Résumé

Obstructive sleep apnea (OSA) may increase the risk of severe COVID-19; however, the level of potential modulation has not yet been established. The objective of the study was to determine the association between high risk of OSA, comorbidities, and increased risk for COVID-19, hospitalization, and intensive care unit (ICU) treatment. We conducted a cross-sectional population-based web survey in adults in 14 countries/regions. The survey included sociodemographic variables and comorbidities. Participants were asked questions about COVID-19, hospitalization, and ICU treatment. Standardized questionnaire (STOP questionnaire for high risk of OSA) was included. Multivariable logistic regression was conducted adjusting for various factors. Out of 26,539 respondents, 20,598 (35.4% male) completed the survey. Mean age and BMI of participants were 41.5 ± 16.0 years and 24.0 ± 5.0 kg/m Participants at high risk of OSA had increased odds of having COVID-19 and were two times more likely to be hospitalized or treated in ICU.

Identifiants

DOI: 10.1007/s11325-021-02373-5 PMID: 33907966 PMC: PMC8079162
pubmed: 33907966
doi: 10.1007/s11325-021-02373-5
pii: 10.1007/s11325-021-02373-5
pmc: PMC8079162
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

849-860

Investigateurs

Ngan Yin Chan (NY)
Courtney J Bolstad (CJ)
Jules Schneider (J)
Ying Huang (Y)
Ana Fernandes (A)

Références

Benjafield AV, Ayas NT, Eastwood PR, Heinzer R, Ip MSM, Morrell MJ, Nunez CM, Patel SR, Penzel T, Pepin JL, Peppard PE, Sinha S, Tufik S, Valentine K, Malhotra A (2019) Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. Lancet Respir Med 7(8):687–698. https://doi.org/10.1016/S2213-2600(19)30198-5
doi: 10.1016/S2213-2600(19)30198-5 pubmed: 31300334 pmcid: 7007763
Young T, Evans L, Finn L, Palta M (1997) Estimation of the clinically diagnosed proportion of sleep apnea syndrome in middle-aged men and women. Sleep 20(9):705–706. https://doi.org/10.1093/sleep/20.9.705
doi: 10.1093/sleep/20.9.705 pubmed: 9406321
Chung F, Yegneswaran B, Liao P, Chung SA, Vairavanathan S, Islam S, Khajehdehi A, Shapiro CM (2008) STOP questionnaire: a tool to screen patients for obstructive sleep apnea. Anesthesiology 108(5):812–821. https://doi.org/10.1097/ALN.0b013e31816d83e4
doi: 10.1097/ALN.0b013e31816d83e4 pubmed: 18431116
Chiu HY, Chen PY, Chuang LP, Chen NH, Tu YK, Hsieh YJ, Wang YC, Guilleminault C (2017) Diagnostic accuracy of the Berlin questionnaire, STOP-BANG, STOP, and Epworth sleepiness scale in detecting obstructive sleep apnea: a bivariate meta-analysis. Sleep Med Rev 36:57–70. https://doi.org/10.1016/j.smrv.2016.10.004
doi: 10.1016/j.smrv.2016.10.004 pubmed: 27919588
Maas MB, Kim M, Malkani RG, Abbott SM, Zee PC (2020) Obstructive sleep apnea and risk of COVID-19 infection, hospitalization and respiratory failure. Sleep Breath. https://doi.org/10.1007/s11325-020-02203-0
Miller MA, Cappuccio FP (2021) A systematic review of COVID-19 and obstructive sleep apnoea. Sleep Med Rev 55:101382. https://doi.org/10.1016/j.smrv.2020.101382
doi: 10.1016/j.smrv.2020.101382 pubmed: 32980614
Cade BE, Dashti HS, Hassan SM, Redline S, Karlson EW (2020) Sleep apnea and COVID-19 mortality and hospitalization. Am J Respir Crit Care Med 202(10):1462–1464. https://doi.org/10.1164/rccm.202006-2252LE
doi: 10.1164/rccm.202006-2252LE pubmed: 32946275 pmcid: 7667903
Peker Y, Celik Y, Arbatli S, Isik SR, Balcan B, Karatas F, Uzel FI, Tabak L, Cetin B, Baygul A, Ozturk AB, Altug E, Iliaz S, Atasoy C, Kapmaz M, Yazici D, Bayram H, Durmaz Cetin B, Caglayan B, Collaborators O-S (2021) Effect of high-risk obstructive sleep apnea on clinical outcomes in adults with coronavirus disease 2019: a multicenter, prospective, observational cohort study. Ann Am Thorac Soc. https://doi.org/10.1513/AnnalsATS.202011-1409OC
Oh TK, Song IA (2021) Impact of coronavirus disease-2019 on chronic respiratory disease in South Korea: an NHIS COVID-19 database cohort study. BMC Pulm Med 21(1):12. https://doi.org/10.1186/s12890-020-01387-1
doi: 10.1186/s12890-020-01387-1 pubmed: 33407347 pmcid: 7787421
Labarca G, Henriquez-Beltran M, Llerena F, Erices G, Lastra J, Enos D, Castillo D, Fraga M, Lamperti L, Ormazabal V, Riffo B, Rubilar D, Sanhueza R, Vasquez J, Villanueva C, Horta G, Sanhueza F, Melo P, Dreyse J, Jorquera J, Fernandez-Bussy S, Gonzalez J, Barbe F, Nova-Lamperti E, Consortium C (2021) Undiagnosed sleep disorder breathing as a risk factor for critical COVID-19 and pulmonary consequences at the midterm follow-up. Sleep Med. https://doi.org/10.1016/j.sleep.2021.02.029
Strausz S, Kiiskinen T, Broberg M, Ruotsalainen S, Koskela J, Bachour A, FinnGen PA, Palotie T, Ripatti S, Ollila HM (2021) Sleep apnoea is a risk factor for severe COVID-19. BMJ Open Respir Res 8(1):e000845. https://doi.org/10.1136/bmjresp-2020-000845
doi: 10.1136/bmjresp-2020-000845 pubmed: 33436406 pmcid: 7804843
Lohia P, Sreeram K, Nguyen P, Choudhary A, Khicher S, Yarandi H, Kapur S, Badr MS (2021) Preexisting respiratory diseases and clinical outcomes in COVID-19: a multihospital cohort study on predominantly African American population. Respir Res 22(1):37. https://doi.org/10.1186/s12931-021-01647-6
doi: 10.1186/s12931-021-01647-6 pubmed: 33546658 pmcid: 7863037
Cariou B, Hadjadj S, Wargny M, Pichelin M, Al-Salameh A, Allix I, Amadou C, Arnault G, Baudoux F, Bauduceau B, Borot S, Bourgeon-Ghittori M, Bourron O, Boutoille D, Cazenave-Roblot F, Chaumeil C, Cosson E, Coudol S, Darmon P, Disse E, Ducet-Boiffard A, Gaborit B, Joubert M, Kerlan V, Laviolle B, Marchand L, Meyer L, Potier L, Prevost G, Riveline JP, Robert R, Saulnier PJ, Sultan A, Thebaut JF, Thivolet C, Tramunt B, Vatier C, Roussel R, Gautier JF, Gourdy P, investigators C (2020) Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study. Diabetologia 63(8):1500–1515. https://doi.org/10.1007/s00125-020-05180-x
doi: 10.1007/s00125-020-05180-x pubmed: 32472191 pmcid: 32472191
Suen CM, Hui DSC, Memtsoudis SG, Chung F (2020) Obstructive sleep apnea, obesity, and noninvasive ventilation: considerations during the COVID-19 pandemic. Anesth Analg 131(2):318–322. https://doi.org/10.1213/ANE.0000000000004928
doi: 10.1213/ANE.0000000000004928 pubmed: 32667157
Perger E, Soranna D, Pengo M, Meriggi P, Lombardi C, Parati G (2021) Sleep-disordered breathing among hospitalized patients with COVID-19. Am J Respir Crit Care Med 203(2):239–241. https://doi.org/10.1164/rccm.202010-3886LE
doi: 10.1164/rccm.202010-3886LE pubmed: 33180549 pmcid: 7874403
Partinen M, Bjorvatn B, Holzinger B, Chung F, Penzel T, Espie CA, Morin CM, group IC-c (2021) Sleep and circadian problems during the coronavirus disease 2019 (COVID-19) pandemic: the International COVID-19 Sleep Study (ICOSS). J Sleep Res 30(1):e13206. https://doi.org/10.1111/jsr.13206
doi: 10.1111/jsr.13206 pubmed: 33179820
Partinen M, Gislason T (1995) Basic Nordic Sleep Questionnaire (BNSQ): a quantitated measure of subjective sleep complaints. J Sleep Res 4(S1):150–155. https://doi.org/10.1111/j.1365-2869.1995.tb00205.x
doi: 10.1111/j.1365-2869.1995.tb00205.x pubmed: 10607192
Kroenke K, Spitzer RL, Williams JB, Lowe B (2009) An ultra-brief screening scale for anxiety and depression: the PHQ-4. Psychosomatics 50(6):613–621. https://doi.org/10.1176/appi.psy.50.6.613
doi: 10.1176/appi.psy.50.6.613 pubmed: 19996233
Pivetta B, Chen L, Nagappa M, Saripella A, Waseem R, Englesakis M, Chung F (2021) Use and performance of the STOP-Bang questionnaire for obstructive sleep apnea screening across geographic regions: a systematic review and meta-analysis. JAMA Netw Open 4(3):e211009. https://doi.org/10.1001/jamanetworkopen.2021.1009
doi: 10.1001/jamanetworkopen.2021.1009 pubmed: 33683333 pmcid: 7941199
Carroll HA, Hook K, Perez OFR, Denckla C, Vince CC, Ghebrehiwet S, Ando K, Touma M, Borba CPC, Fricchione GL, Henderson DC (2020) Establishing reliability and validity for mental health screening instruments in resource-constrained settings: systematic review of the PHQ-9 and key recommendations. Psychiatry Res 291:113236. https://doi.org/10.1016/j.psychres.2020.113236
doi: 10.1016/j.psychres.2020.113236 pubmed: 32593853
Atkins JL, Masoli JAH, Delgado J, Pilling LC, Kuo CL, Kuchel GA, Melzer D (2020) Preexisting comorbidities predicting COVID-19 and mortality in the UK Biobank community cohort. J Gerontol A Biol Sci Med Sci 75(11):2224–2230. https://doi.org/10.1093/gerona/glaa183
doi: 10.1093/gerona/glaa183 pubmed: 32687551 pmcid: 7454409
Williamson EJ, Walker AJ, Bhaskaran K, Bacon S, Bates C, Morton CE, Curtis HJ, Mehrkar A, Evans D, Inglesby P, Cockburn J, McDonald HI, MacKenna B, Tomlinson L, Douglas IJ, Rentsch CT, Mathur R, Wong AYS, Grieve R, Harrison D, Forbes H, Schultze A, Croker R, Parry J, Hester F, Harper S, Perera R, Evans SJW, Smeeth L, Goldacre B (2020) Factors associated with COVID-19-related death using OpenSAFELY. Nature 584(7821):430–436. https://doi.org/10.1038/s41586-020-2521-4
doi: 10.1038/s41586-020-2521-4
Karamanli H, Ozol D, Ugur KS, Yildirim Z, Armutcu F, Bozkurt B, Yigitoglu R (2014) Influence of CPAP treatment on airway and systemic inflammation in OSAS patients. Sleep Breath 18(2):251–256. https://doi.org/10.1007/s11325-012-0761-8
doi: 10.1007/s11325-012-0761-8 pubmed: 22945540
Roncon L, Zuin M, Rigatelli G, Zuliani G (2020) Diabetic patients with COVID-19 infection are at higher risk of ICU admission and poor short-term outcome. J Clin Virol 127:104354. https://doi.org/10.1016/j.jcv.2020.104354
doi: 10.1016/j.jcv.2020.104354 pubmed: 32305882 pmcid: 7195018
Yang J, Zheng Y, Gou X, Pu K, Chen Z, Guo Q, Ji R, Wang H, Wang Y, Zhou Y (2020) Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis. Int J Infect Dis 94:91–95. https://doi.org/10.1016/j.ijid.2020.03.017
doi: 10.1016/j.ijid.2020.03.017 pubmed: 7194638 pmcid: 7194638
Fang L, Karakiulakis G, Roth M (2020) Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Lancet Respir Med 8(4):e21. https://doi.org/10.1016/S2213-2600(20)30116-8
doi: 10.1016/S2213-2600(20)30116-8 pubmed: 7118626 pmcid: 7118626
Wan Y, Shang J, Graham R, Baric RS, Li F (2020) Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus. J Virol 94(7). https://doi.org/10.1128/JVI.00127-20
Richardson S, Hirsch JS, Narasimhan M, Crawford JM, McGinn T, Davidson KW, the Northwell C-RC, Barnaby DP, Becker LB, Chelico JD, Cohen SL, Cookingham J, Coppa K, Diefenbach MA, Dominello AJ, Duer-Hefele J, Falzon L, Gitlin J, Hajizadeh N, Harvin TG, Hirschwerk DA, Kim EJ, Kozel ZM, Marrast LM, Mogavero JN, Osorio GA, Qiu M, Zanos TP (2020) Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area. JAMA 323(20):2052–2059. https://doi.org/10.1001/jama.2020.6775
doi: 10.1001/jama.2020.6775 pubmed: 32320003 pmcid: 32320003
Scully EP, Haverfield J, Ursin RL, Tannenbaum C, Klein SL (2020) Considering how biological sex impacts immune responses and COVID-19 outcomes. Nat Rev Immunol 20(7):442–447. https://doi.org/10.1038/s41577-020-0348-8
doi: 10.1038/s41577-020-0348-8 pubmed: 32528136
Harris M, Glozier N, Ratnavadivel R, Grunstein RR (2009) Obstructive sleep apnea and depression. Sleep Med Rev 13(6):437–444. https://doi.org/10.1016/j.smrv.2009.04.001
doi: 10.1016/j.smrv.2009.04.001 pubmed: 19596599
Schroder CM, O'Hara R (2005) Depression and obstructive sleep apnea (OSA). Ann Gen Psychiatry 4:13. https://doi.org/10.1186/1744-859X-4-13
doi: 10.1186/1744-859X-4-13 pubmed: 15982424 pmcid: 1181621
Wang Q, Xu R, Volkow ND (2021) Increased risk of COVID-19 infection and mortality in people with mental disorders: analysis from electronic health records in the United States. World Psychiatry 20(1):124–130. https://doi.org/10.1002/wps.20806
doi: 10.1002/wps.20806 pubmed: 33026219
Bonanad C, Garcia-Blas S, Tarazona-Santabalbina F, Sanchis J, Bertomeu-Gonzalez V, Facila L, Ariza A, Nunez J, Cordero A (2020) The effect of age on mortality in patients with COVID-19: a meta-analysis with 611,583 subjects. J Am Med Dir Assoc 21(7):915–918. https://doi.org/10.1016/j.jamda.2020.05.045
doi: 10.1016/j.jamda.2020.05.045 pubmed: 32674819 pmcid: 7247470
Zhang Y, Ren R, Lei F, Zhou J, Zhang J, Wing YK, Sanford LD, Tang X (2019) Worldwide and regional prevalence rates of co-occurrence of insomnia and insomnia symptoms with obstructive sleep apnea: a systematic review and meta-analysis. Sleep Med Rev 45:1–17. https://doi.org/10.1016/j.smrv.2019.01.004
doi: 10.1016/j.smrv.2019.01.004 pubmed: 30844624
Silva GE, Vana KD, Goodwin JL, Sherrill DL, Quan SF (2011) Identification of patients with sleep disordered breathing: comparing the four-variable screening tool, STOP, STOP-Bang, and Epworth Sleepiness Scales. J Clin Sleep Med 7(5):467–472. https://doi.org/10.5664/JCSM.1308
doi: 10.5664/JCSM.1308 pubmed: 22003341 pmcid: 3190845
Naranjo M, Willes L, Prillaman BA, Quan SF, Sharma S (2020) Undiagnosed OSA may significantly affect outcomes in adults admitted for COPD in an inner-city hospital. Chest 158(3):1198–1207. https://doi.org/10.1016/j.chest.2020.03.036
doi: 10.1016/j.chest.2020.03.036 pubmed: 32247716

Auteurs

Frances Chung (F)

Department of Anesthesia and Pain Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, M5T2S8, Canada. Frances.chung@uhn.ca.
Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Ontario, Canada. Frances.chung@uhn.ca.
ORCID: 0000-0001-9576-3606

Rida Waseem (R)

Department of Anesthesia and Pain Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, M5T2S8, Canada.

Chi Pham (C)

Department of Anesthesia and Pain Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, M5T2S8, Canada.
Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Ontario, Canada.

Thomas Penzel (T)

Sleep Medicine Center, Charite Universitätsmedizin Berlin, Berlin, Germany.

Fang Han (F)

Department of Respiratory Medicine, Peking University People's Hospital, Beijing, China.

Bjørn Bjorvatn (B)

Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Norwegian Competence Center for Sleep Disorders, Haukeland University Hospital, Bergen, Norway.

Charles M Morin (CM)

École de Psychologie, Centre d'étude des troubles du sommeil, Centre de recherche CERVO/Brain Research Center, Université Laval, Québec, Canada.

Brigitte Holzinger (B)

Institute for Dream and Consciousness Research, Medical University of Vienna, Vienna, Austria.

Colin A Espie (CA)

Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

Christian Benedict (C)

Department of Neuroscience, Sleep Science (BMC), Uppsala University, Uppsala, Sweden.

Jonathan Cedernaes (J)

Department of Neuroscience, Sleep Science (BMC), Uppsala University, Uppsala, Sweden.
Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University, Chicago, IL, USA.

Tarja Saaresranta (T)

Division of Medicine, Department of Pulmonary Diseases, Turku University Hospital, Turku, Finland.

Yun Kwok Wing (YK)

Li Chiu Kong Family Sleep Assessment Unit, Departments of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China.

Michael R Nadorff (MR)

Department of Psychology, Mississippi State University, Starkville, USA.
Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, USA.

Yves Dauvilliers (Y)

Sleep-Wake Disorders Center, Department of Neurology, Gui-de-Chauliac Hospital, Institute for Neurosciences of Montpellier INM, INSERM, University of Montpellier, Montpellier, France.

Luigi De Gennaro (L)

Department of Psychology, Sapienza University of Rome, Rome, Italy.
IRCCS Fondazione Santa Lucia, Rome, Italy.

Guiseppe Plazzi (G)

IRCCS, Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.

Ilona Merikanto (I)

Department of Psychology and Logopedics and SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Kentaro Matsui (K)

Department of Clinical Laboratory and Department of Sleep-Wake Disorders, National Center of Neurology and Psychiatry National Institute of Mental Health, Kodaira, Japan.
Department of Psychiatry, Tokyo Women's Medical University, Tokyo, Japan.

Damien Leger (D)

Sleep and Vigilance Center, Hopital Hotel-Dieu de Paris, Paris, France.
Universite de Paris, VIFASOM (EA 7331 Vigilance Fatigue Sommeil et Santé Publique), Paris, France.

Mariusz Sieminski (M)

Department of Emergency Medicine, Medical University of Gdansk, Gdansk, Poland.

Sergio Mota-Rolim (S)

Brain Institute, Onofre Lopes University Hospital, Natal, Brazil.
Physiology and Behavior Department, Federal University of Rio Grande do Norte, Natal, Brazil.

Yuichi Inoue (Y)

Department of Somnology, Tokyo Medical University, Tokyo, Japan.
Japan Somnology Center, Neuropsychiatric Research Institute, Tokyo, Japan.

Markku Partinen (M)

Helsinki Sleep Clinic, Vitalmed Research Center, and Department of Neurosciences, Clinicum, University of Helsinki, Helsinki, Finland.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › The association between high risk of sleep...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › The association between high risk of sleep...
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Dépistage de la COVID-19 › The association between high risk of sleep...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Comorbidité › The association between high risk of sleep...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › The association between high risk of sleep...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Dépression › The association between high risk of sleep...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › The association between high risk of sleep...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › The association between high risk of sleep...
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questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › The association between high risk of sleep...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › Prévalence › The association between high risk of sleep...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › The association between high risk of sleep...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Facteurs sexuels › The association between high risk of sleep...
questionsmedicales.fr › Maladies du système nerveux › Syndromes d'apnées du sommeil › Syndrome d'apnées obstructives du sommeil › The association between high risk of sleep...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Ronflement › The association between high risk of sleep...