Selective attention to emotional stimuli and emotion recognition in patients with major depression: The role of mineralocorticoid and glutamatergic NMDA receptors.
Adult
Case-Control Studies
Cognition
/ drug effects
Cycloserine
/ pharmacology
Depressive Disorder, Major
/ physiopathology
Emotions
/ drug effects
Facial Recognition
/ drug effects
Female
Fludrocortisone
/ pharmacology
Humans
Male
Middle Aged
Receptors, Mineralocorticoid
/ drug effects
Receptors, N-Methyl-D-Aspartate
/ agonists
Young Adult
Mineralocorticoid receptor
NMDA receptor
depression
emotion recognition
selective attention
Journal
Journal of psychopharmacology (Oxford, England)
ISSN: 1461-7285
Titre abrégé: J Psychopharmacol
Pays: United States
ID NLM: 8907828
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
pubmed:
29
4
2021
medline:
3
2
2022
entrez:
28
4
2021
Statut:
ppublish
Résumé
Mineralocorticoid receptors (MR) are highly expressed in limbic brain areas and prefrontal cortex, which are closely related to selective attention to emotional stimuli and emotion recognition. Patients with major depressive disorder (MDD) show alterations in MR functioning and both cognitive processes. MR stimulation improves cognitive processes in MDD and leads to glutamate release that binds upon N-methyl-D-aspartate receptors (NMDA-R). We examined (1) whether MR stimulation has beneficial effects on selective attention to emotional stimuli and on emotion recognition and (2) whether these advantageous effects can be improved by simultaneous NMDA-R stimulation. We examined 116 MDD patients and 116 healthy controls matched for age ( Patients with MDD and healthy individuals did not differ in task performance. MR stimulation had no effect on both cognitive processes in both groups. Across groups, NMDA-R stimulation had no effect on selective attention but showed a small effect on emotion recognition by increasing accuracy to recognize angry faces. Relatively young unmedicated MDD patients showed no depression-related cognitive deficits compared with healthy controls. Separate MR and simultaneous MR and NMDA-R stimulation revealed no advantageous effects on cognition, but NMDA-R might be involved in emotion recognition.
Sections du résumé
BACKGROUND
BACKGROUND
Mineralocorticoid receptors (MR) are highly expressed in limbic brain areas and prefrontal cortex, which are closely related to selective attention to emotional stimuli and emotion recognition. Patients with major depressive disorder (MDD) show alterations in MR functioning and both cognitive processes. MR stimulation improves cognitive processes in MDD and leads to glutamate release that binds upon N-methyl-D-aspartate receptors (NMDA-R).
AIMS
OBJECTIVE
We examined (1) whether MR stimulation has beneficial effects on selective attention to emotional stimuli and on emotion recognition and (2) whether these advantageous effects can be improved by simultaneous NMDA-R stimulation.
METHODS
METHODS
We examined 116 MDD patients and 116 healthy controls matched for age (
RESULTS
RESULTS
Patients with MDD and healthy individuals did not differ in task performance. MR stimulation had no effect on both cognitive processes in both groups. Across groups, NMDA-R stimulation had no effect on selective attention but showed a small effect on emotion recognition by increasing accuracy to recognize angry faces.
CONCLUSIONS
CONCLUSIONS
Relatively young unmedicated MDD patients showed no depression-related cognitive deficits compared with healthy controls. Separate MR and simultaneous MR and NMDA-R stimulation revealed no advantageous effects on cognition, but NMDA-R might be involved in emotion recognition.
Identifiants
pubmed: 33908312
doi: 10.1177/02698811211009797
doi:
Substances chimiques
NR3C2 protein, human
0
Receptors, Mineralocorticoid
0
Receptors, N-Methyl-D-Aspartate
0
Cycloserine
95IK5KI84Z
Fludrocortisone
U0476M545B
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM