Comparison of the contributions of impaired beta cell function and insulin resistance to the development of type 2 diabetes in a Japanese community: the Hisayama Study.
Adult
Aged
Asian People
/ ethnology
Blood Glucose
/ metabolism
Diabetes Mellitus, Type 2
/ epidemiology
Female
Follow-Up Studies
Glucose Tolerance Test
Humans
Insulin Resistance
/ physiology
Insulin Secretion
Insulin-Secreting Cells
/ metabolism
Japan
/ epidemiology
Male
Middle Aged
Proportional Hazards Models
Prospective Studies
Risk Factors
Beta cell function
Epidemiology
Insulin resistance
Insulin secretion
Normal glucose tolerance
Obesity
Prediabetes
Prospective study
Type 2 diabetes
Journal
Diabetologia
ISSN: 1432-0428
Titre abrégé: Diabetologia
Pays: Germany
ID NLM: 0006777
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
22
12
2020
accepted:
15
02
2021
pubmed:
29
4
2021
medline:
19
3
2022
entrez:
28
4
2021
Statut:
ppublish
Résumé
Our aim was to compare the contributions of impaired beta cell function (IBF) and insulin resistance with the development of type 2 diabetes in a Japanese community. A total of 2094 residents aged 40-79 years without diabetes underwent a health examination including a 75 g OGTT in 2007. Participants were divided into four groups according to the presence or absence of IBF (insulinogenic index/HOMA-IR ≤28.5) and insulin resistance (HOMA-IR ≥1.61) and were followed up for 7 years (2007-2014). Cox's proportional hazards model was used to estimate HRs and 95% CIs for type 2 diabetes. The population attributable fractions (PAFs) due to IBF, insulin resistance, and their combination were calculated. At baseline, the prevalence of isolated IBF, isolated insulin resistance, and both IBF and insulin resistance were 5.4%, 24.1% and 9.5%, respectively. During the follow-up period, 272 participants developed type 2 diabetes. The multivariable-adjusted HRs (95% CI) and PAFs (95% CI) for type 2 diabetes were 6.3 (4.3, 9.2) and 13.3% (8.7, 17.7) in the participants with isolated IBF, 1.9 (1.3, 2.7) and 10.5% (4.0, 16.6) in those with isolated insulin resistance, and 8.0 (5.7, 11.4) and 29.3% (23.0, 35.1) in those with both IBF and insulin resistance, respectively, compared with the participants without either. The present study suggests that the combination of IBF and insulin resistance makes the main contribution to the development of type 2 diabetes in Japanese communities.
Identifiants
pubmed: 33909115
doi: 10.1007/s00125-021-05459-7
pii: 10.1007/s00125-021-05459-7
doi:
Substances chimiques
Blood Glucose
0
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1775-1784Références
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