Association of estimated glomerular filtration rate from serum creatinine and cystatin C with new-onset diabetes: a nationwide cohort study in China.
CHARLS
Creatinine
Cystatin C
EGFR
New-onset diabetes
Journal
Acta diabetologica
ISSN: 1432-5233
Titre abrégé: Acta Diabetol
Pays: Germany
ID NLM: 9200299
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
07
01
2021
accepted:
11
04
2021
pubmed:
29
4
2021
medline:
8
10
2021
entrez:
28
4
2021
Statut:
ppublish
Résumé
The association between estimated glomerular filtration rate (eGFR) and the risk of diabetes remains uncertain. We aimed to examine the association between eGFR based on creatinine (eGFRcr), cystatin C (eGFRcys), or a combination of both (eGFRcr-cys) and new-onset diabetes, using data from the China Health and Retirement Longitudinal Study (CHARLS), a nationally representative cohort study. A total of 4,775 participants with pertinent measurements and without diabetes at baseline from CHARLS were included in the final analysis. The eGFR was calculated by creatinine, cystatin C or a combination of both using the Chronic Kidney Disease Epidemiology Collaboration equations. The study outcome was new-onset diabetes, defined as physician-diagnosed diabetes or use of glucose-lowering drugs during follow-up, or fasting glucose ≥ 126 mg/dL, random glucose ≥ 200 mg/dL, or HbA1c ≥ 6.5% (48 mmol/mol) at the exit visit. The mean age of the study population was 59.6 years. The mean values for the eGFRcr, eGFRcys, and eGFRcr-cys were 92.4, 78.9 and 85.9 mL/min/1.73m Lower eGFRcr-cys (< 60 mL/min/1.73m
Identifiants
pubmed: 33909121
doi: 10.1007/s00592-021-01719-5
pii: 10.1007/s00592-021-01719-5
doi:
Substances chimiques
Cystatin C
0
Creatinine
AYI8EX34EU
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1269-1276Subventions
Organisme : National Natural Science Foundation
ID : 81973133, 81730019
Informations de copyright
© 2021. Springer-Verlag Italia S.r.l., part of Springer Nature.
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