Intron 4-5 hTERT DNA Hypermethylation in Merkel Cell Carcinoma: Frequency, Association with Other Clinico-pathological Features and Prognostic Relevance.
HTERT
HTERT intron 4–5
Merkel cell carcinoma
Merkel cell polyomavirus
Methylation
Rs10069690
Telomerase
Journal
Endocrine pathology
ISSN: 1559-0097
Titre abrégé: Endocr Pathol
Pays: United States
ID NLM: 9009288
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
accepted:
15
02
2021
pubmed:
29
4
2021
medline:
18
1
2022
entrez:
28
4
2021
Statut:
ppublish
Résumé
Merkel cell carcinoma (MCC) is an aggressive skin tumor with neuroendocrine differentiation, mainly affecting elderly population or immunocompromised individuals. As methylation of the human telomerase reverse transcriptase (mhTERT) has been shown to be a prognostic factor in different tumors, we investigated its role in MCC, in particular in intron 4-5 where rs10069690 has been mapped and recognized as a cancer susceptibility locus. DNA methylation analysis of hTERT gene was assessed retrospectively in a cohort of 69 MCC patients from the University of Bologna, University of Turin and University of Insubria. Overall mortality was evaluated with Kaplan-Meier curves and multivariable Royston-Parmar models. High levels of mhTERT (mhTERT
Identifiants
pubmed: 33909215
doi: 10.1007/s12022-021-09669-y
pii: 10.1007/s12022-021-09669-y
pmc: PMC8370894
doi:
Substances chimiques
TERT protein, human
EC 2.7.7.49
Telomerase
EC 2.7.7.49
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
385-395Informations de copyright
© 2021. The Author(s).
Références
Endocr Relat Cancer. 2017 Feb;24(2):107-117
pubmed: 28062544
Neurosurg Rev. 2020 Jun;43(3):903-910
pubmed: 30788677
Int J Cancer. 2011 Aug 1;129(3):619-28
pubmed: 20949558
Neuro Oncol. 2019 May 6;21(5):616-627
pubmed: 30668814
Int J Mol Med. 2018 Sep;42(3):1675-1683
pubmed: 29956721
Am J Surg Pathol. 1980 Jun;4(3):211-21
pubmed: 7396063
Cancer Res. 2015 Sep 15;75(18):3720-3727
pubmed: 26238782
Cancer Res. 2007 Mar 15;67(6):2626-31
pubmed: 17363582
Biochem Biophys Res Commun. 2007 Sep 28;361(3):615-20
pubmed: 17673177
J Hematol Oncol. 2014 Jul 20;7:47
pubmed: 25042800
Ann Surg Oncol. 2009 Apr;16(4):1051-9
pubmed: 19194757
Exp Cell Res. 2003 Oct 1;289(2):326-34
pubmed: 14499633
J Neurooncol. 2014 Aug;119(1):215-6
pubmed: 24825541
Cancer Immunol Res. 2013 Jul;1(1):54-63
pubmed: 24416729
Diagn Progn Res. 2020 Apr 2;4:3
pubmed: 32266321
J Appl Genet. 2018 Nov;59(4):453-461
pubmed: 30088231
Am J Hum Genet. 2013 Nov 7;93(5):876-90
pubmed: 24183450
Cancer. 2007 Aug 1;110(3):640-7
pubmed: 17599745
Stat Med. 2014 Dec 30;33(30):5280-97
pubmed: 25220693
Mod Pathol. 2014 Jun;27(6):869-74
pubmed: 24287456
Bioinformatics. 2002 Nov;18(11):1427-31
pubmed: 12424112
Nucleic Acids Res. 2018 Jul 2;46(W1):W537-W544
pubmed: 29790989
Endocr Pathol. 2019 Sep;30(3):246-248
pubmed: 31154561
Epigenetics. 2020 Dec;15(12):1319-1324
pubmed: 32475296
Neuro Oncol. 2018 Jul 5;20(8):1009-1010
pubmed: 29982653
Mod Pathol. 2019 Sep;32(9):1359-1372
pubmed: 30976104
J Neurooncol. 2016 Oct;130(1):79-87
pubmed: 27465278
Brain Tumor Pathol. 2016 Jan;33(1):27-34
pubmed: 26390879
Clin Epigenetics. 2017 Aug 15;9:85
pubmed: 28814981
Hum Pathol. 2018 Jan;71:117-125
pubmed: 29079179
Oncotarget. 2014 Oct 30;5(20):10048-57
pubmed: 25301727
Oncotarget. 2016 Sep 6;7(36):57726-57736
pubmed: 27437772
J Mol Diagn. 2021 Feb;23(2):212-222
pubmed: 33197629
Hum Mol Genet. 2014 Dec 15;23(24):6616-33
pubmed: 25027329
Arch Dermatol. 1972 Jan;105(1):107-10
pubmed: 5009611
Br J Haematol. 2016 Nov;175(3):427-439
pubmed: 27433923
Oncotarget. 2017 Nov 24;8(65):109228-109237
pubmed: 29312603
Diagn Progn Res. 2018 Feb 7;2:4
pubmed: 31093554
Clin Cancer Res. 2018 Dec 1;24(23):5873-5882
pubmed: 30061360
Lancet Oncol. 2013 May;14(6):534-42
pubmed: 23598174
J Invest Dermatol. 2017 Jan;137(1):197-206
pubmed: 27592799
J Am Acad Dermatol. 2010 Nov;63(5):751-61
pubmed: 20646783
Clin Res Hepatol Gastroenterol. 2015 Oct;39(5):600-9
pubmed: 25683523
Int J Oncol. 2016 Dec;49(6):2199-2205
pubmed: 27779655
Biomarkers. 2009 Dec;14(8):630-6
pubmed: 20001710
Nucleic Acids Res. 2009 Aug;37(14):4603-12
pubmed: 19494183
Endocr Pathol. 2020 Mar;31(1):21-32
pubmed: 31808008
Endocr Pathol. 2020 Dec;31(4):392-400
pubmed: 32696301
J Cutan Pathol. 2017 Sep;44(9):740-746
pubmed: 28569410
J Biomed Sci. 2018 Mar 12;25(1):22
pubmed: 29526163
J Am Acad Dermatol. 2015 Nov;73(5):864-5
pubmed: 26475538
Hum Pathol. 2010 Oct;41(10):1405-12
pubmed: 20594584
Mod Pathol. 2011 Nov;24(11):1451-61
pubmed: 21765392
APMIS. 2017 Sep;125(9):797-807
pubmed: 28766760
Nucleic Acids Res. 2019 Jul 2;47(W1):W166-W170
pubmed: 31106358
World J Gastroenterol. 2012 May 21;18(19):2334-43
pubmed: 22654424