SDH Subunit C Regulates Muscle Oxygen Consumption and Fatigability in an Animal Model of Pulmonary Emphysema.
COPD
muscle respiration
pulmonary emphysema
succinate dehydrogenase
Journal
American journal of respiratory cell and molecular biology
ISSN: 1535-4989
Titre abrégé: Am J Respir Cell Mol Biol
Pays: United States
ID NLM: 8917225
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
pubmed:
29
4
2021
medline:
15
9
2021
entrez:
28
4
2021
Statut:
ppublish
Résumé
Patients with pulmonary emphysema often develop locomotor muscle dysfunction, which is independently associated with disability and higher mortality in that population. Muscle dysfunction entails reduced force generation capacity, which partially depends on fibers' oxidative potential, yet very little mechanistic research has focused on muscle respiration in pulmonary emphysema. Using a recently established animal model of pulmonary emphysema-driven skeletal muscle dysfunction, we found downregulation of SDHC (succinate dehydrogenase subunit C) in association with lower oxygen consumption and fatigue tolerance in locomotor muscles. Reduced SDH activity has been previously observed in muscles from patients with pulmonary emphysema, and we found that SDHC is required to support respiration in cultured muscle cells. Moreover,
Identifiants
pubmed: 33909984
doi: 10.1165/rcmb.2020-0551OC
pmc: PMC8485989
doi:
Substances chimiques
Membrane Proteins
0
SDHC protein, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
259-271Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL049426
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142807
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM108538
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL115813
Pays : United States
Organisme : NHLBI NIH HHS
ID : K01 HL130704
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL114501
Pays : United States
Commentaires et corrections
Type : CommentIn
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