Steroidal alkaloids isolated from Veratrum grandiflorum Loes. as novel Smoothened inhibitors with anti-proliferation effects on DAOY medulloblastoma cells.
Alkaloids
Anti-proliferation
Hedgehog pathway
Medulloblastoma
Smo inhibitor
Veratrum grandiglorum Loes.
Journal
Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298
Informations de publication
Date de publication:
01 06 2021
01 06 2021
Historique:
received:
11
12
2020
revised:
07
04
2021
accepted:
16
04
2021
pubmed:
29
4
2021
medline:
10
11
2021
entrez:
28
4
2021
Statut:
ppublish
Résumé
Constitutive activation of Hedgehog (Hh) pathway is intimately related with the occurrence and development of several malignancies, such as medulloblastoma (MB) and other tumors. Therefore, small molecular inhibitors of Hh pathway are urgently needed. In this study, three new steroidal alkaloids, ⊿
Identifiants
pubmed: 33910157
pii: S0968-0896(21)00174-7
doi: 10.1016/j.bmc.2021.116166
pii:
doi:
Substances chimiques
Alkaloids
0
SMO protein, human
0
Smoothened Receptor
0
Steroids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
116166Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.