Galectin-3 and neutrophil-to-lymphocyte ratio are indicative of heart remodelling and disease severity in patients with obstructive sleep apnoea.

Adult Aged Blood Proteins Female Galectin 3 Galectins Humans Lymphocytes Male Middle Aged Neutrophils Polysomnography Severity of Illness Index Sleep Apnea, Obstructive
Echocardiography Fibrosis marker Galectin-3 Left ventricular dysfunction Neutrophil-to-lymphocyte ratio Obstructive sleep apnoea

Journal

Sleep medicine
ISSN: 1878-5506
Titre abrégé: Sleep Med
Pays: Netherlands
ID NLM: 100898759

Informations de publication

Date de publication:
06 2021
Historique:
received: 19 12 2020
revised: 08 03 2021
accepted: 29 03 2021
pubmed: 29 4 2021
medline: 6 7 2021
entrez: 28 4 2021
Statut: ppublish

Résumé

Galectin-3, considered as a new inflammatory marker; it is increased in cardiovascular disease. We investigated Galectin-3 in relation to heart damage in patients with OSA and its role in inflammation, based on the Neutrophil-to-Lymphocyte Ratio (NLR). Sixty-three consecutive patients (45 males, 18 females, 58.60 ± 12.28 years old) were studied. According to the Apnoea-Hypopnoea Index (AHI) patients were divided into Group 1 - non-severe (AHI <30) (17 males and 10 females, 59.89 ± 10.62 years old) and Group 2 - severe (AHI ≥30) (29 males and 6 females, aged 57.53 ± 13.30 years old) OSA. All patients underwent morning blood gas analysis, laboratory tests, nocturnal polygraphy, and echocardiography. Galectin-3 was significantly increased in Group 2 (p = 0.027) patients. Moreover, it was directly related to left ventricle (LV) mass, left ventricle hypertrophy and LV posterior wall diameter. Tissue Doppler septal velocity (e'), that measures wall motion, was inversely correlated to Galectin-3. Furthermore, a direct association to diastolic dysfunction, evaluated as E/e' ratio, was observed. In line with these data, a direct correlation between Galectin-3 and left atrium volume was also found. Galectin-3 and percentage of total registration time with nocturnal oxygen saturation <90% (TST90) were directly correlated (p = 0.0003), while Galectin-3 and mean nocturnal SpO Galectin-3 showed a direct association to nocturnal respiratory indices and to cardiac remodelling in patients with OSA. OSA-induced inflammation may play an important role in the pathogenesis of heart damage.

Sections du résumé

BACKGROUND
Galectin-3, considered as a new inflammatory marker; it is increased in cardiovascular disease. We investigated Galectin-3 in relation to heart damage in patients with OSA and its role in inflammation, based on the Neutrophil-to-Lymphocyte Ratio (NLR).
METHODS
Sixty-three consecutive patients (45 males, 18 females, 58.60 ± 12.28 years old) were studied. According to the Apnoea-Hypopnoea Index (AHI) patients were divided into Group 1 - non-severe (AHI <30) (17 males and 10 females, 59.89 ± 10.62 years old) and Group 2 - severe (AHI ≥30) (29 males and 6 females, aged 57.53 ± 13.30 years old) OSA. All patients underwent morning blood gas analysis, laboratory tests, nocturnal polygraphy, and echocardiography.
RESULTS
Galectin-3 was significantly increased in Group 2 (p = 0.027) patients. Moreover, it was directly related to left ventricle (LV) mass, left ventricle hypertrophy and LV posterior wall diameter. Tissue Doppler septal velocity (e'), that measures wall motion, was inversely correlated to Galectin-3. Furthermore, a direct association to diastolic dysfunction, evaluated as E/e' ratio, was observed. In line with these data, a direct correlation between Galectin-3 and left atrium volume was also found. Galectin-3 and percentage of total registration time with nocturnal oxygen saturation <90% (TST90) were directly correlated (p = 0.0003), while Galectin-3 and mean nocturnal SpO
CONCLUSION
Galectin-3 showed a direct association to nocturnal respiratory indices and to cardiac remodelling in patients with OSA. OSA-induced inflammation may play an important role in the pathogenesis of heart damage.

Identifiants

DOI: 10.1016/j.sleep.2021.03.039 PMID: 33910161
pubmed: 33910161
pii: S1389-9457(21)00210-0
doi: 10.1016/j.sleep.2021.03.039
pii:
doi:

Substances chimiques

Blood Proteins 0
Galectin 3 0
Galectins 0
LGALS3 protein, human 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

117-124

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Sebastiano Cicco (S)

Unit of Internal Medicine "Guido Baccelli", Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro Medical School, Piazza Giulio Cesare 11, I-70124 Bari, BA, Italy. Electronic address: sebastiano.cicco@uniba.it.

Giorgio Castellana (G)

Respiratory Rehabilitation, Istituti Clinici Scientifici Maugeri IRCCS, Bari, BA, Italy.

Lorenzo Marra (L)

UOC Pneumologia, Presidio Ospedaliero San Giuseppe Moscati, Taranto, TA, Italy.

Valentina Di Lecce (V)

Department of Cardiac, Thoracic, and Vascular Science, Institute of Respiratory Disease, University of Bari Aldo Moro Medical School, Piazza Giulio Cesare 11, I-70124 Bari, BA, Italy.

Pierluigi Carratù (P)

Department of Cardiac, Thoracic, and Vascular Science, Institute of Respiratory Disease, University of Bari Aldo Moro Medical School, Piazza Giulio Cesare 11, I-70124 Bari, BA, Italy.

Marcella Prete (M)

Unit of Internal Medicine "Guido Baccelli", Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro Medical School, Piazza Giulio Cesare 11, I-70124 Bari, BA, Italy.

Giuseppe Ranieri (G)

Unit of Internal Medicine "Guido Baccelli", Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro Medical School, Piazza Giulio Cesare 11, I-70124 Bari, BA, Italy.

Onofrio Resta (O)

Department of Cardiac, Thoracic, and Vascular Science, Institute of Respiratory Disease, University of Bari Aldo Moro Medical School, Piazza Giulio Cesare 11, I-70124 Bari, BA, Italy.

Giovanna Elisiana Carpagnano (GE)

Department of Cardiac, Thoracic, and Vascular Science, Institute of Respiratory Disease, University of Bari Aldo Moro Medical School, Piazza Giulio Cesare 11, I-70124 Bari, BA, Italy.

Vito Racanelli (V)

Unit of Internal Medicine "Guido Baccelli", Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro Medical School, Piazza Giulio Cesare 11, I-70124 Bari, BA, Italy.

Silvano Dragonieri (S)

Department of Cardiac, Thoracic, and Vascular Science, Institute of Respiratory Disease, University of Bari Aldo Moro Medical School, Piazza Giulio Cesare 11, I-70124 Bari, BA, Italy.

Angelo Vacca (A)

Unit of Internal Medicine "Guido Baccelli", Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro Medical School, Piazza Giulio Cesare 11, I-70124 Bari, BA, Italy.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Galectin-3 and neutrophil-to-lymphocyte ratio...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Galectin-3 and neutrophil-to-lymphocyte ratio...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Galectin-3 and neutrophil-to-lymphocyte ratio...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lectines › Galectines › Galectine -3 › Galectin-3 and neutrophil-to-lymphocyte ratio...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lectines › Galectines › Galectin-3 and neutrophil-to-lymphocyte ratio...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Galectin-3 and neutrophil-to-lymphocyte ratio...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Galectin-3 and neutrophil-to-lymphocyte ratio...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Galectin-3 and neutrophil-to-lymphocyte ratio...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Granulocytes neutrophiles › Galectin-3 and neutrophil-to-lymphocyte ratio...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Monitorage physiologique › Polysomnographie › Galectin-3 and neutrophil-to-lymphocyte ratio...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Acuité des besoins du patient › Indice de gravité de la maladie › Galectin-3 and neutrophil-to-lymphocyte ratio...
questionsmedicales.fr › Maladies du système nerveux › Syndromes d'apnées du sommeil › Syndrome d'apnées obstructives du sommeil › Galectin-3 and neutrophil-to-lymphocyte ratio...