Location and temporal memory of objects declines in aged marmosets (Callithrix jacchus).
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
28 04 2021
28 04 2021
Historique:
received:
23
06
2020
accepted:
12
04
2021
entrez:
29
4
2021
pubmed:
30
4
2021
medline:
21
10
2021
Statut:
epublish
Résumé
Episodic memory decline is an early marker of cognitive aging in human. Although controversial in animals and called "episodic-like memory", several models have been successfully developed, however they rarely focused on ageing. While marmoset is an emerging primate model in aging science, episodic-like memory has never been tested in this species and importantly in aged marmosets. Here, we examined if the recall of the what-when and what-where building blocks of episodic-like memory declines in ageing marmosets. We developed a naturalistic approach using spontaneous exploration of real objects by young and old marmosets in the home cage. We implemented a three-trial task with 1 week inter-trial interval. Two different sets of identical objects were presented in sample trials 1 and 2, respectively. For the test trial, two objects from each set were presented in a former position and two in a new one. We quantified the exploratory behaviour and calculated discrimination indices in a cohort of 20 marmosets. Young animals presented a preserved memory for combined what-where, and what-when components of the experiment, which declined with aging. These findings lead one to expect episodic-like memory deficits in aged marmosets.
Identifiants
pubmed: 33911122
doi: 10.1038/s41598-021-88357-7
pii: 10.1038/s41598-021-88357-7
pmc: PMC8080792
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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