Prenatal transplantation of human amniotic fluid stem cell could improve clinical outcome of type III spinal muscular atrophy in mice.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
28 04 2021
28 04 2021
Historique:
received:
31
12
2020
accepted:
14
04
2021
entrez:
29
4
2021
pubmed:
30
4
2021
medline:
2
2
2023
Statut:
epublish
Résumé
Spinal muscular atrophy (SMA) is a single gene disorder affecting motor function in uterus. Amniotic fluid is an alternative source of stem cell to ameliorate SMA. Therefore, this study aims to examine the therapeutic potential of Human amniotic fluid stem cell (hAFSC) for SMA. Our SMA model mice were generated by deletion of exon 7 of Smn gene and knock-in of human SMN2. A total of 16 SMA model mice were injected with 1 × 10
Identifiants
pubmed: 33911155
doi: 10.1038/s41598-021-88559-z
pii: 10.1038/s41598-021-88559-z
pmc: PMC8080644
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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