Effect of blood transfusions on cognitive development in very low birth weight infants.
Journal
Journal of perinatology : official journal of the California Perinatal Association
ISSN: 1476-5543
Titre abrégé: J Perinatol
Pays: United States
ID NLM: 8501884
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
20
07
2020
accepted:
04
02
2021
revised:
16
12
2020
pubmed:
30
4
2021
medline:
9
10
2021
entrez:
29
4
2021
Statut:
ppublish
Résumé
Preterm infants frequently receive red cell transfusions; however, the effect of transfusions on cognition is unclear. We evaluated the relationship between transfusions and cognitive outcomes in preterm infants enrolled in a randomized trial of erythropoiesis stimulating agents (ESAs). Preterm infants were randomized to ESAs or placebo during initial hospitalization, and transfusions recorded. Children were evaluated using standard developmental tests of cognition at 18-22 months (56 ESA, 24 placebo) and 3.5-4 years (39 ESA, 14 placebo). Cognitive scores at 18-22 months were inversely correlated with transfusion volume (p = 0.02). Among those receiving ≥1 transfusion, cognitive scores were significantly higher in the ESA-treated group (p = 0.003). At 3.5-4 years, transfusions were not correlated with cognitive scores. In the placebo group, transfused children had lower cognitive scores than did non-transfused children at 18-22 months. In the ESA group, cognitive scores did not differ by transfusion status, suggesting ESAs might provide neuroprotection.
Identifiants
pubmed: 33911186
doi: 10.1038/s41372-021-00997-9
pii: 10.1038/s41372-021-00997-9
pmc: PMC8238787
mid: NIHMS1670716
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1412-1418Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR000041
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001067
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD059856
Pays : United States
Références
Jeon G, Sin J. Risk factors of transfusion in anemia of very low birth weight infants. Yonsei Med J. 2013;54:366–73.
doi: 10.3349/ymj.2013.54.2.366
Wang Y-C, Chan O-W, Chiang M-C, Yang P-H, Chu S-M, Hsu J-F, et al. Red blood cell transfusion and clinical outcomes in extremely low birth weight preterm infants. Pediatr Neonatol. 2017;58:216–22.
doi: 10.1016/j.pedneo.2016.03.009
Valieva O, Strandjord T, Mayock D, Juul S. Effects of transfusions in extremely low birth weight infants: a retrospective study. J Pediatr. 2009;155:331–8.
doi: 10.1016/j.jpeds.2009.02.026
Christensen R. Associations between “early” red blood cell transfusion and severe intraventricular hemorrhage, and between “late” red blood cell transfusion and necrotizing enterocolitis. Semin Perinatol. 2012;36:283–9.
doi: 10.1053/j.semperi.2012.04.009
Christensen R, Baer V, Lambert D, Ilstrup S, Eggert L, Henry E. Association, among very-low-birthweight neonates, between red blood cell transfusions in the week after birth and severe intraventricular hemorrhage. Transfusion. 2014;54:104–8.
doi: 10.1111/trf.12234
Baer V, Lambert D, Henry E, Snow G, Butler A, Christensen R. Among very-low-birth-weight neonates is red blood cell transfusion an independent risk factor for subsequently developing a severe intraventricular hemorrhage? Transfusion. 2011;51:1170–8.
doi: 10.1111/j.1537-2995.2010.02980.x
Ohlsson A, Aher SM. Early erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants. Cochrane Database Syst Rev. 2014;4:1–84.
Ohls R, Christensen R, Kamath-Rayne B, Rosenberg A, Wiedmeier S, Roohi M, et al. A randomized, masked, placebo-controlled study of darbepoetin alfa in preterm infants. Pediatrics. 2013;132:e119–27.
doi: 10.1542/peds.2013-0143
Ohls R, Kamath-Rayne B, Christensen R, Wiedmeier S, Rosenberg A, Fuller J, et al. Cognitive outcomes of preterm infants randomized to darbepoetin, erythropoietin, or placebo. Pediatrics. 2014;133:1023–30.
doi: 10.1542/peds.2013-4307
Ohls R, Cannon D, Phillips J, Caprihan A, Patel S, Winter S, et al. Preschool assessment of preterm infants treated with darbepoetin and erythropoietin. Pediatrics. 2016;137:1–11.
doi: 10.1542/peds.2015-3859
Carson J, Carless P, Hébert P. Outcomes using lower vs higher hemoglobin thresholds for red blood cell transfusion. JAMA. 2013;309:83–4.
doi: 10.1001/jama.2012.50429
Rohde J, Dimcheff D, Blumberg N, Saint S, Langa K, Kuhn L, et al. Health care–associated infection after red blood cell transfusion. JAMA. 2014;311:1317–26.
doi: 10.1001/jama.2014.2726
Patel N, Avlonitis V, Jones H, Reeves B, Sterne J, Murphy G. Indications for red blood cell transfusion in cardiac surgery: a systematic review and meta-analysis. Lancet Haematol. 2015;2:e543–53.
doi: 10.1016/S2352-3026(15)00198-2
Murphy G, Pike K, Rogers C, Wordsworth S, Stokes E, Angelini G, et al. Liberal or restrictive transfusion after cardiac surgery. NEJM. 2015;372:997–1008.
doi: 10.1056/NEJMoa1403612
Jairath V, Kahan B, Gray A, Doré C, Mora A, James M, et al. Restrictive versus liberal blood transfusion for acute upper gastrointestinal bleeding (TRIGGER): a pragmatic, open-label, cluster randomised feasibility trial. Lancet. 2015;386:137–44.
doi: 10.1016/S0140-6736(14)61999-1
Fominskiy E, Putzu A, Monaco F, Scandroglio A, Karaskov A, Galas F, et al. Liberal transfusion strategy improves survival in perioperative but not in critically ill patients. A meta-analysis of randomised trials. Br J Anaesth. 2015;115:511–9.
doi: 10.1093/bja/aev317
Goobie S, Faraoni D, Zurakowski D, DiNardo J. Association of preoperative anemia with postoperative mortality in neonates. JAMA Pediatr. 2016;170:855–62.
doi: 10.1001/jamapediatrics.2016.1032
Patel R, Knezevic A, Shenvi N, Hinkes M, Keene S, Roback J, et al. Association of red blood cell transfusion, anemia, and necrotizing enterocolitis in very low-birth-weight infants. JAMA. 2016;315:889–97.
doi: 10.1001/jama.2016.1204
dos Santos A, Guinsburg R, Branco de Almeida B, Procianoy R, Leone C, Marba S, et al. Red blood cell transfusions are independently associated with intra-hospital mortality in very low birth weight preterm infants. J Pediatr. 2011;159:371–6.
doi: 10.1016/j.jpeds.2011.02.040
Whyte R, Kirpalani H. Low versus high haemoglobin concentration threshold for blood transfusion for preventing morbidity and mortality in very low birth weight infants (review). Cochrane Database Syst Rev. 2011;11:1–55.
Whyte R, Kirpalani H, Asztalos E, Andersen C, Blajchman M, Heddle N, et al. Neurodevelopmental outcome of extremely low birth weight infants randomly assigned to restrictive or liberal hemoglobin thresholds for blood transfusion. Pediatrics. 2009;123:207–13.
doi: 10.1542/peds.2008-0338
Neubauer A, Voss W, Wachtendorf M, Jungmann T. Erythropoietin improves neurodevelopmental outcome of extremely preterm infants. Ann Neurol. 2010;67:657–66.
pubmed: 20437563
Kirpalani H, Whyte R, Andersen C, Asztalos E, Heddle N, Blajchman M, et al. The premature infants in need of transfusion (pint) study: a randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants. J Pediatr. 2006;149:301–7.
doi: 10.1016/j.jpeds.2006.05.011
Bell E, Strauss R, Widness J, Mahoney L, Mock D, Seward V, et al. Randomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants. Pediatrics. 2005;115:1685–91.
doi: 10.1542/peds.2004-1884
Nopoulous P, Conrad A, Bell E, Strauss R, Widness J, Magnotta V, et al. Long-term outcome of brain structure in premature infants: effects of liberal vs restricted red blood cell transfusions. Arch Pediatr Adolesc Med. 2011;165(May):443–50.
Kirpalani H, Bell EF, Hintz SR, Tan S, Schmidt B, Chaudhary AS, et al. Higher or lower hemoglobin transfusion thresholds for preterm infants. N Engl J Med. 2020;383:2639–51.
doi: 10.1056/NEJMoa2020248
Franz AR, Engel C, Bassler D, Rudiger M, Thorne UH, Maier RF, et al. Effects of liberal vs restrictive transfusion thresholds on survival and neurocognitive outcomes in extremely low-birth-weight infants: the ETTNO randomized clinical trial. JAMA. 2020;324:560–70.
doi: 10.1001/jama.2020.10690
Fauchere J, Koller B, Tschopp A, Dame C, Ruegger C, Bucher H. Safety of early high-dose recombinant erythropoietin for neuroprotection in very preterm infants. J Pediatr. 2015;167:52–7.
doi: 10.1016/j.jpeds.2015.02.052
Rangarajan V, Juul S. Erythropoietin: emerging role of erythropoietin in neonatal neuroprotection. Pediatr Neurol. 2014;51:481–8.
doi: 10.1016/j.pediatrneurol.2014.06.008
Leuchter R, Gui L, Poncet A, Hagmann C, Lodygensky G, Martin E, et al. Association between early administration of high-dose erythropoietin in preterm infants and brain MRI abnormality at term-equivalent age. JAMA. 2014;312:817–24.
doi: 10.1001/jama.2014.9645
O’Gorman R, Bucher H, Held U, Koller B, Huppi P, Hagmann C, et al. Tract-based spatial statistics to assess the neuroprotective effect of early erythropoietin on white matter development in preterm infants. Brain. 2015;138:388–97.
doi: 10.1093/brain/awu363
Dani C, Poggi C, Gozzini E, Leonardi V, Serent A, Abbate R, et al. Red blood cell transfusions can induce proinflammatory cytokines in preterm infants. Transfusion. 2017;57:1304–10.
doi: 10.1111/trf.14080