Fibroblasts as immune regulators in infection, inflammation and cancer.


Journal

Nature reviews. Immunology
ISSN: 1474-1741
Titre abrégé: Nat Rev Immunol
Pays: England
ID NLM: 101124169

Informations de publication

Date de publication:
11 2021
Historique:
accepted: 11 03 2021
pubmed: 30 4 2021
medline: 15 12 2021
entrez: 29 4 2021
Statut: ppublish

Résumé

In chronic infection, inflammation and cancer, the tissue microenvironment controls how local immune cells behave, with tissue-resident fibroblasts emerging as a key cell type in regulating activation or suppression of an immune response. Fibroblasts are heterogeneous cells, encompassing functionally distinct populations, the phenotypes of which differ according to their tissue of origin and type of inciting disease. Their immunological properties are also diverse, ranging from the maintenance of a potent inflammatory environment in chronic inflammation to promoting immunosuppression in malignancy, and encapsulating and incarcerating infectious agents within tissues. In this Review, we compare the mechanisms by which fibroblasts control local immune responses, as well as the factors regulating their inflammatory and suppressive profiles, in different tissues and pathological settings. This cross-disease perspective highlights the importance of tissue context in determining fibroblast-immune cell interactions, as well as potential therapeutic avenues to exploit this knowledge for the benefit of patients with chronic infection, inflammation and cancer.

Identifiants

pubmed: 33911232
doi: 10.1038/s41577-021-00540-z
pii: 10.1038/s41577-021-00540-z
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

704-717

Subventions

Organisme : Versus Arthritis
ID : 22253
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S025308/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S035850/1
Pays : United Kingdom

Informations de copyright

© 2021. Springer Nature Limited.

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Auteurs

Sarah Davidson (S)

The Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.

Mark Coles (M)

The Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.

Tom Thomas (T)

The Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.

George Kollias (G)

Institute for Fundamental Biomedical Research, Biomedical Sciences Research Center "Alexander Fleming", Vari, Greece.
Institute for Bioinnovation, Biomedical Sciences Research Center "Alexander Fleming", Vari, Greece.
Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Burkhard Ludewig (B)

Institute of Immunobiology, Kantonsspital St. Gallen, St Gallen, Switzerland.
Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.

Shannon Turley (S)

Department of Cancer Immunology, Genentech, San Francisco, CA, USA.

Michael Brenner (M)

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Christopher D Buckley (CD)

The Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK. christopher.buckley@kennedy.ox.ac.uk.
Rheumatology Research Group, Institute for Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK. christopher.buckley@kennedy.ox.ac.uk.

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