Fibroblasts as immune regulators in infection, inflammation and cancer.
Journal
Nature reviews. Immunology
ISSN: 1474-1741
Titre abrégé: Nat Rev Immunol
Pays: England
ID NLM: 101124169
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
accepted:
11
03
2021
pubmed:
30
4
2021
medline:
15
12
2021
entrez:
29
4
2021
Statut:
ppublish
Résumé
In chronic infection, inflammation and cancer, the tissue microenvironment controls how local immune cells behave, with tissue-resident fibroblasts emerging as a key cell type in regulating activation or suppression of an immune response. Fibroblasts are heterogeneous cells, encompassing functionally distinct populations, the phenotypes of which differ according to their tissue of origin and type of inciting disease. Their immunological properties are also diverse, ranging from the maintenance of a potent inflammatory environment in chronic inflammation to promoting immunosuppression in malignancy, and encapsulating and incarcerating infectious agents within tissues. In this Review, we compare the mechanisms by which fibroblasts control local immune responses, as well as the factors regulating their inflammatory and suppressive profiles, in different tissues and pathological settings. This cross-disease perspective highlights the importance of tissue context in determining fibroblast-immune cell interactions, as well as potential therapeutic avenues to exploit this knowledge for the benefit of patients with chronic infection, inflammation and cancer.
Identifiants
pubmed: 33911232
doi: 10.1038/s41577-021-00540-z
pii: 10.1038/s41577-021-00540-z
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
704-717Subventions
Organisme : Versus Arthritis
ID : 22253
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S025308/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S035850/1
Pays : United Kingdom
Informations de copyright
© 2021. Springer Nature Limited.
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