Structural basis of GABA

Cryoelectron Microscopy GTP-Binding Proteins / chemistry Humans Protein Binding Protein Domains Protein Multimerization Protein Structure, Tertiary Receptors, GABA-B / chemistry

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
06 2021
Historique:
received: 14 01 2021
accepted: 29 03 2021
pubmed: 30 4 2021
medline: 14 1 2022
entrez: 29 4 2021
Statut: ppublish

Résumé

G-protein-coupled receptors (GPCRs) have central roles in intercellular communication

Identifiants

DOI: 10.1038/s41586-021-03507-1 PMID: 33911284 PMC: PMC8222003
pubmed: 33911284
doi: 10.1038/s41586-021-03507-1
pii: 10.1038/s41586-021-03507-1
pmc: PMC8222003
doi:

Substances chimiques

Receptors, GABA-B 0
GTP-Binding Proteins EC 3.6.1.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

594-598

Références

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Auteurs

Cangsong Shen (C)

ZJU-HUST Joint Laboratory of Cellular Signaling, Key Laboratory of Molecular Biophysics of MOE, International Research Center for Sensory Biology and Technology of MOST, College of Life Science and Technology, Huazhong University of Science and Technology (HUST), Wuhan, China.
Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China.

Chunyou Mao (C)

Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China.
Zhejiang Provincial Key Laboratory of Immunity and Inflammatory Diseases, Hangzhou, China.
ORCID: 0000-0001-5349-8592

Chanjuan Xu (C)

ZJU-HUST Joint Laboratory of Cellular Signaling, Key Laboratory of Molecular Biophysics of MOE, International Research Center for Sensory Biology and Technology of MOST, College of Life Science and Technology, Huazhong University of Science and Technology (HUST), Wuhan, China.
Bioland Laboratory, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China.
ORCID: 0000-0002-5640-1896

Nan Jin (N)

ZJU-HUST Joint Laboratory of Cellular Signaling, Key Laboratory of Molecular Biophysics of MOE, International Research Center for Sensory Biology and Technology of MOST, College of Life Science and Technology, Huazhong University of Science and Technology (HUST), Wuhan, China.
Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China.

Huibing Zhang (H)

Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China.
Zhejiang Provincial Key Laboratory of Immunity and Inflammatory Diseases, Hangzhou, China.
ORCID: 0000-0003-3025-0185

Dan-Dan Shen (DD)

Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China.
Zhejiang Provincial Key Laboratory of Immunity and Inflammatory Diseases, Hangzhou, China.
ORCID: 0000-0001-8757-4602

Qingya Shen (Q)

Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China.
Zhejiang Provincial Key Laboratory of Immunity and Inflammatory Diseases, Hangzhou, China.
ORCID: 0000-0001-6602-7116

Xiaomei Wang (X)

ZJU-HUST Joint Laboratory of Cellular Signaling, Key Laboratory of Molecular Biophysics of MOE, International Research Center for Sensory Biology and Technology of MOST, College of Life Science and Technology, Huazhong University of Science and Technology (HUST), Wuhan, China.

Tingjun Hou (T)

Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.

Zhong Chen (Z)

Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, Zhejiang Chinese Medical University, Hangzhou, China.
ORCID: 0000-0003-4755-9357

Philippe Rondard (P)

Institut de Génomique Fonctionnelle (IGF), Université de Montpellier, CNRS, INSERM, 34094, Montpellier, France.
ORCID: 0000-0003-1134-2738

Jean-Philippe Pin (JP)

Institut de Génomique Fonctionnelle (IGF), Université de Montpellier, CNRS, INSERM, 34094, Montpellier, France. jean-philippe.pin@igf.cnrs.fr.
ORCID: 0000-0002-1423-345X

Yan Zhang (Y)

Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. zhang_yan@zju.edu.cn.
Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China. zhang_yan@zju.edu.cn.
Zhejiang Provincial Key Laboratory of Immunity and Inflammatory Diseases, Hangzhou, China. zhang_yan@zju.edu.cn.
MOE Frontier Science Center for Brain Research and Brain-Machine Integration, Zhejiang University School of Medicine, Hangzhou, China. zhang_yan@zju.edu.cn.
ORCID: 0000-0003-2189-0244

Jianfeng Liu (J)

ZJU-HUST Joint Laboratory of Cellular Signaling, Key Laboratory of Molecular Biophysics of MOE, International Research Center for Sensory Biology and Technology of MOST, College of Life Science and Technology, Huazhong University of Science and Technology (HUST), Wuhan, China. jfliu@mail.hust.edu.cn.
Bioland Laboratory, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China. jfliu@mail.hust.edu.cn.
ORCID: 0000-0002-0284-8377

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Cryomicroscopie électronique › Structural basis of GABA
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Structural basis of GABA
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Structural basis of GABA
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Structural basis of GABA
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure tertiaire des protéines › Domaines protéiques › Structural basis of GABA
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Multimérisation de protéines › Structural basis of GABA
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure tertiaire des protéines › Structural basis of GABA
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs GABA › Récepteurs GABA-B › Structural basis of GABA