Sex Hormones, Metabolic Status, and Obesity in Female Patients with Acne Vulgaris Along with Clinical Correlation: An Observational Cross-Sectional Study.
Acne
metabolic syndrome
severity
sex hormones
Journal
Indian journal of dermatology
ISSN: 1998-3611
Titre abrégé: Indian J Dermatol
Pays: India
ID NLM: 0370750
Informations de publication
Date de publication:
Historique:
entrez:
29
4
2021
pubmed:
30
4
2021
medline:
30
4
2021
Statut:
ppublish
Résumé
Acne vulgaris is a common dermatological disorder. Several hormones are suspected to play a role in its etiopathogenesis. The aim of this study was to analyze the role of sex-hormones, metabolic status, and obesity in acne vulgaris and correlate with its severity and symptom load. This cross-sectional observational study included 89 female patients with acne vulgaris and certain phenotypic markers such as prepubertal onset, late-onset, persistent course, hirsutism, acanthosis nigricans, acrochordons, premenstrual flare, and diminished response to isotretinoin; suggestive of an underlying hormonal pathology. All patients were subjected to physical examination to rule out obesity and metabolic syndrome along with serum biochemistry to detect sex hormones (testosterone, progesterone, estrogen), serum insulin and insulin resistance (HOMA-IR) and lipid profile. Among 89 patients (mean age 21.3 ± 5.3 years), 34.8% presented with late-onset/persistent/pre-pubertal acne, 33.7% presented with premenstrual flare and 28.2% presented with hirsutism. Hormonal analysis revealed elevated testosterone and progesterone with low estrogen across all categories of patients. Testosterone was significantly elevated even in mild acne. Serum lipid profile was altered significantly only in hirsute females. In total, 36% and 20.2% patients presented with metabolic syndrome and obesity, respectively; however, neither was associated with severity of acne. Sex-hormones, serum lipids, metabolic status, and body mass index are altered in acne vulgaris. All acne patients with endocrine markers should be evaluated for sex-hormones irrespective of severity and symptom load, whereas hirsutism may be regarded as clinical marker of lipid abnormalities. Metabolic syndrome and obesity do not seem to be directly correlated with acne severity. Thus, anti-androgens may be considered as adjuvant therapy in these patients, not responding to conventional therapy.
Sections du résumé
BACKGROUND
BACKGROUND
Acne vulgaris is a common dermatological disorder. Several hormones are suspected to play a role in its etiopathogenesis.
AIMS AND OBJECTIVES
OBJECTIVE
The aim of this study was to analyze the role of sex-hormones, metabolic status, and obesity in acne vulgaris and correlate with its severity and symptom load.
MATERIALS AND METHODS
METHODS
This cross-sectional observational study included 89 female patients with acne vulgaris and certain phenotypic markers such as prepubertal onset, late-onset, persistent course, hirsutism, acanthosis nigricans, acrochordons, premenstrual flare, and diminished response to isotretinoin; suggestive of an underlying hormonal pathology. All patients were subjected to physical examination to rule out obesity and metabolic syndrome along with serum biochemistry to detect sex hormones (testosterone, progesterone, estrogen), serum insulin and insulin resistance (HOMA-IR) and lipid profile.
RESULTS
RESULTS
Among 89 patients (mean age 21.3 ± 5.3 years), 34.8% presented with late-onset/persistent/pre-pubertal acne, 33.7% presented with premenstrual flare and 28.2% presented with hirsutism. Hormonal analysis revealed elevated testosterone and progesterone with low estrogen across all categories of patients. Testosterone was significantly elevated even in mild acne. Serum lipid profile was altered significantly only in hirsute females. In total, 36% and 20.2% patients presented with metabolic syndrome and obesity, respectively; however, neither was associated with severity of acne.
CONCLUSION
CONCLUSIONS
Sex-hormones, serum lipids, metabolic status, and body mass index are altered in acne vulgaris. All acne patients with endocrine markers should be evaluated for sex-hormones irrespective of severity and symptom load, whereas hirsutism may be regarded as clinical marker of lipid abnormalities. Metabolic syndrome and obesity do not seem to be directly correlated with acne severity. Thus, anti-androgens may be considered as adjuvant therapy in these patients, not responding to conventional therapy.
Identifiants
pubmed: 33911295
doi: 10.4103/ijd.IJD_82_20
pii: IJD-66-60
pmc: PMC8061487
doi:
Types de publication
Journal Article
Langues
eng
Pagination
60-66Informations de copyright
Copyright: © 2021 Indian Journal of Dermatology.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
Références
Indian J Dermatol. 2018 Jul-Aug;63(4):328-331
pubmed: 30078878
J Drugs Dermatol. 2009 Jul;8(7):615-8
pubmed: 19588637
Diabetes Res Clin Pract. 2003 Jun;60(3):199-204
pubmed: 12757982
J Dermatol Sci. 2005 Apr;38(1):1-7
pubmed: 15795118
Fertil Steril. 2001 May;75(5):889-92
pubmed: 11334899
Clin Exp Dermatol. 2015 Dec;40(8):844-50
pubmed: 26011595
Clin Dermatol. 2018 Jan - Feb;36(1):29-40
pubmed: 29241749
Pak J Med Sci. 2019 Jan-Feb;35(1):146-150
pubmed: 30881413
Int J Dermatol. 1997 Jun;36(6):416-8
pubmed: 9248884
JAMA Dermatol. 2016 Apr;152(4):399-404
pubmed: 26720707
Dermatology. 2013;226(2):167-71
pubmed: 23689531
Exp Dermatol. 2010 May;19(5):470-2
pubmed: 20337700
Clin Cosmet Investig Dermatol. 2015 Aug 17;8:449-54
pubmed: 26316790
J Clin Diagn Res. 2014 May;8(5):OC01-3
pubmed: 24995216
Eur J Dermatol. 2006 May-Jun;16(3):251-3
pubmed: 16709487
J Clin Aesthet Dermatol. 2017 Oct;10(10):18-24
pubmed: 29344316
Indian Dermatol Online J. 2014 Nov;5(Suppl 1):S9-S16
pubmed: 25506579
Indian J Dermatol. 2018 Mar-Apr;63(2):131-135
pubmed: 29692454
J Am Acad Dermatol. 2005 Dec;53(6):955-8
pubmed: 16310054
N Engl J Med. 1983 Apr 28;308(17):981-6
pubmed: 6220224
Clin Dermatol. 2017 Mar - Apr;35(2):130-137
pubmed: 28274349
J Ayub Med Coll Abbottabad. 2016 Apr-Jun;28(2):357-359
pubmed: 28718568
Clin Biochem. 2010 Dec;43(18):1415-20
pubmed: 20880492
Clin Biochem. 2011 Sep;44(13):1035-1040
pubmed: 21763298