Bleomycin Sclerotherapy in Massive Macrocystic Lymphatic Malformation: Minimal Complications with Maximum Results.
Bleomycin
lymphangiomas
sclerotherapy
Journal
Journal of cutaneous and aesthetic surgery
ISSN: 0974-2077
Titre abrégé: J Cutan Aesthet Surg
Pays: India
ID NLM: 101525405
Informations de publication
Date de publication:
Historique:
entrez:
29
4
2021
pubmed:
30
4
2021
medline:
30
4
2021
Statut:
ppublish
Résumé
Cystic lymphangioma (CL) is a multiloculated congenital malformation of the lymphatic system occurring in approximately 1 in 6,000-12,000 births, and it mostly presents at birth. The CL is of a variable size and it can be found at any age and in any part of the body. This study was carried out to observe the effect of intralesional aqueous bleomycin on giant CL presenting in adult and pediatric cases. This is an observational study conducted in the department of pediatric surgery and plastic surgery from January 2012 to January 2020. All the diagnosed cases of lymphangioma measuring more than 5 cm in size and managed during this period were reviewed. The cases who had lesions with a vascular component or who had any history of previous surgery or any form of treatment were excluded from the study. A total of 19 cases were included in the study. The primary mode of management of CL at the present center is intralesional bleomycin sclerotherapy (IBS). This is the standard protocol followed at our center to treat the cases with CL. Relevant demographic and clinical data of all the included patients were collected on a structured proforma, and data were analyzed. Four cases had a favorable outcome in a single session, seven cases showed a favorable response after the second session, and three cases showed a favorable response after the third session. Two cases showed a partial response even after the fourth session and were considered nonresponders, one of whom was operated on and the other who was satisfied with a partial response and was not willing to undergo surgical excision. No major complications were observed in the present series. A few cases developed mild pain with or without fever, but none of them required hospitalization. Intralesional bleomycin sclerotherapy (IBS) is a safe, effective, and economical treatment option for the management of large cystic lymphangiomas and it avoids surgery-related complications.Level of Study: IV evidence studyType of Study: Retrospective observational study.
Identifiants
pubmed: 33911413
doi: 10.4103/JCAS.JCAS_108_20
pii: JCAS-13-319
pmc: PMC8061645
doi:
Types de publication
Journal Article
Langues
eng
Pagination
319-325Informations de copyright
Copyright: © 2020 Journal of Cutaneous and Aesthetic Surgery.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
Références
J Indian Assoc Pediatr Surg. 2020 Mar-Apr;25(2):80-84
pubmed: 32139985
Indian J Plast Surg. 2018 Jan-Apr;51(1):60-65
pubmed: 29928081
Natl J Maxillofac Surg. 2010 Jan;1(1):81-5
pubmed: 22442559
Otolaryngol Head Neck Surg. 2008 Apr;138(4):418-24
pubmed: 18359347
Int J Pediatr Otorhinolaryngol. 1987 Dec;14(2-3):133-40
pubmed: 3436717
J Craniofac Surg. 2016 Oct;27(7):1802-1803
pubmed: 27513783
Oral Oncol. 2011 Dec;47(12):1105-9
pubmed: 21906990
Otolaryngol Head Neck Surg. 1999 Oct;121(4):381-7
pubmed: 10504592
J Cutan Aesthet Surg. 2012 Apr;5(2):133-6
pubmed: 23060708
Surg Today. 2016 Jan;46(1):97-101
pubmed: 25682445
Acta Otorhinolaryngol Ital. 2008 Feb;28(1):17-20
pubmed: 18533550
J Cutan Aesthet Surg. 2010 Sep;3(3):139-44
pubmed: 21430825
Oral Maxillofac Surg. 2020 Mar;24(1):109-115
pubmed: 31960163
Ann Otol Rhinol Laryngol. 2002 Dec;111(12 Pt 1):1066-75
pubmed: 12498366
J Craniofac Surg. 2014 Sep;25(5):1707-9
pubmed: 25119414
J Pediatr Surg. 1996 Apr;31(4):477-80
pubmed: 8801295
Clinics (Sao Paulo). 2014 Aug;69(8):505-8
pubmed: 25141107
Br J Oral Maxillofac Surg. 2004 Feb;42(1):66-8
pubmed: 14706307
J Craniofac Surg. 2020 May/Jun;31(3):e250-e251
pubmed: 31977688
Head Neck. 2010 Aug;32(8):1088-98
pubmed: 19924783
Nihon Geka Hokan. 1977 Sep 1;46(5):607-14
pubmed: 73364