Maternal and Perinatal Outcomes of Influenza in Pregnancy after Treatment with Oseltamivir.
Influenza
influenza like illness
pregnancy
preterm birth
small for gestational age
Journal
Journal of global infectious diseases
ISSN: 0974-777X
Titre abrégé: J Glob Infect Dis
Pays: India
ID NLM: 101521436
Informations de publication
Date de publication:
Historique:
received:
31
05
2020
revised:
15
07
2020
accepted:
18
08
2020
entrez:
29
4
2021
pubmed:
30
4
2021
medline:
30
4
2021
Statut:
epublish
Résumé
Influenza infection in pregnancy causes 4%-8% case fatality and five times more perinatal mortality. Influenza is a major contributor to mortality in developing countries; however, the morbidity has largely been underestimated. Public health interventions for prevention are also lacking. This study aimed to determine the seasonality of influenza in pregnant Indian women and to estimate the maternal and perinatal morbidity after treatment with oseltamivir. This was a prospective observational cohort study, conducted in a tertiary hospital. Pregnant women with ILI (influenza-like illness) were recruited into Cohort 1 (polymerase chain reaction [PCR] positive) and Cohort 2 (PCR negative). Gestational age-matched asymptomatic controls formed Cohort 3. Women in Cohort 1 received oseltamivir for 5 days. The incidence of small-for-gestational age (SGA) and preterm birth were the primary outcomes. Maternal and neonatal morbidity formed the secondary outcomes. Unmatched (Cohort 1 and 2) and matched analysis (Cohort 1 and 3) were done. Student's Year-round incidence of influenza was recorded. Severe illness was more in Cohort 1 compared to Cohort 2 (36.2% vs. 6.3%; Influenza in pregnancy showed year-round incidence and increased maternal and neonatal morbidity despite treatment with oseltamivir. We suggest the need for newer interventions to curtail the illness in pregnancy.
Identifiants
pubmed: 33911448
doi: 10.4103/jgid.jgid_157_20
pii: JGID-13-20
pmc: PMC8054794
doi:
Types de publication
Journal Article
Langues
eng
Pagination
20-26Informations de copyright
Copyright: © 2021 Journal of Global Infectious Diseases.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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