Association of Chronic Pain with Radiologic Severity and Central Sensitization in Hip Osteoarthritis Patients.
hip osteoarthritis
pressure pain threshold
quantitative sensory testing
temporal summation of pain
Journal
Journal of pain research
ISSN: 1178-7090
Titre abrégé: J Pain Res
Pays: New Zealand
ID NLM: 101540514
Informations de publication
Date de publication:
2021
2021
Historique:
received:
09
12
2020
accepted:
17
03
2021
entrez:
29
4
2021
pubmed:
30
4
2021
medline:
30
4
2021
Statut:
epublish
Résumé
Pain and joint deformity are the most common symptoms of hip osteoarthritis (OA). However, no significant association between pain and severity of radiographic lesions has been reported. Recently, central sensitization has been suggested as an underlying mechanism of pain in OA. We investigated the involvement of radiologic severity or central sensitization in the clinical manifestation of hip OA with various degrees of joint deformity. We included 39 patients with hip OA and divided them into two groups according to the severity of the hip pain: strong/severe (numerical rating scale, NRS≥6) and mild/moderate (NRS<6). We assessed the radiologic severity of OA using the Kellgren-Lawrence (K-L) scale and minimum joint space width (mJSW). We conducted quantitative sensory testing (QST) that included pressure pain threshold (PPT) and temporal summation of pain (TSP) at hip, tibialis anterior (leg), and extensor carpi radialis longus (arm) on the affected side. We examined the difference of radiologic assessment and QST results between each group and the correlation of the NRS with the radiologic assessment and QST results. There was no significant difference in the K-L scale and mJSW between patients with strong/severe and mild/moderate joint pain. Strong/severe pain patients demonstrated a lower PPT at all measurement sites and higher TSP at the hip and leg than the mild/moderate pain patients. In addition, NRS was significantly negatively correlated with PPT and positively correlated with TSP at all measurement sites, but not with the K-L scale and mJSW. We reported no significant difference in radiologic severity between patients with strong/severe and mild/moderate joint pain. By contrast, we found a significant difference in central sensitization represented by QST between strong/severe and mild/moderate joint pain groups. These results suggest that central sensitization may be involved in the joint pain of patients with hip OA who complain of severe pain despite less severe joint deformity.
Identifiants
pubmed: 33911897
doi: 10.2147/JPR.S296273
pii: 296273
pmc: PMC8075310
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1153-1160Informations de copyright
© 2021 Hattori et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
Références
Pain. 2008 Jul 15;137(2):422-427
pubmed: 18035495
Scand J Rheumatol. 2003;32(1):46-51
pubmed: 12635946
J Pain Symptom Manage. 2013 Jul;46(1):30-42
pubmed: 23102562
Ann Rheum Dis. 1957 Dec;16(4):494-502
pubmed: 13498604
J Orthop Sports Phys Ther. 2019 Oct;49(10):698-715
pubmed: 31443625
Am J Epidemiol. 1990 Sep;132(3):514-22
pubmed: 2389755
Evid Based Complement Alternat Med. 2013;2013:187182
pubmed: 23762107
Pain. 2011 Mar;152(3 Suppl):S2-S15
pubmed: 20961685
J Pain. 2018 Aug;19(8):819-836
pubmed: 29454976
Lancet. 2005 Mar 12-18;365(9463):965-73
pubmed: 15766999
J Physiol. 1990 Jul;426:265-80
pubmed: 2231399
Arthritis Rheum. 2009 Sep 15;61(9):1226-34
pubmed: 19714588
Osteoarthritis Cartilage. 2016 Jan;24(1):117-23
pubmed: 26241774
BMJ Open. 2012 Feb 22;2(1):e000435
pubmed: 22357571
Pain. 2017 Feb;158(2):323-332
pubmed: 27870648
Pain. 2003 Mar;102(1-2):87-95
pubmed: 12620600
Rheumatology (Oxford). 2012 Mar;51(3):535-43
pubmed: 22120461
Pain. 2010 Jun;149(3):573-581
pubmed: 20418016
Neuron. 2007 Aug 2;55(3):365-76
pubmed: 17678851
J Rheumatol. 2005 Jun;32(6):1147-9
pubmed: 15977351
Hum Brain Mapp. 2015 Dec;36(12):5038-50
pubmed: 26366748
Neurosci Lett. 1993 Apr 16;153(1):9-12
pubmed: 8510831
Osteoarthritis Cartilage. 2013 Apr;21(4):570-3
pubmed: 23376014
Pain Med. 2016 Sep;17(9):1694-703
pubmed: 26893116
Clin Rheumatol. 2016 Jun;35(6):1555-64
pubmed: 26445941
Ann Rheum Dis. 2004 Apr;63(4):395-401
pubmed: 15020333
Osteoarthritis Cartilage. 2012 Oct;20(10):1075-85
pubmed: 22796624
Lancet. 2011 Jun 18;377(9783):2115-26
pubmed: 21684382
Curr Med Res Opin. 2006 Oct;22(10):1911-20
pubmed: 17022849
PLoS One. 2018 Jun 14;13(6):e0199165
pubmed: 29902245
Best Pract Res Clin Rheumatol. 2011 Apr;25(2):209-26
pubmed: 22094197
Exp Brain Res. 2006 Apr;170(2):182-90
pubmed: 16328284
Pain. 2006 Jul;123(1-2):6-9
pubmed: 16714085
Pain. 1997 Aug;72(1-2):95-7
pubmed: 9272792