Effects of Aleurone Supplementation on Glucose-Insulin Metabolism and Gut Microbiome in Untrained Healthy Horses.
Bacteroidetes
Firmicutes
betaine
equine
ferulic acid
gut health
insulin sensitivity
prebiotic
Journal
Frontiers in veterinary science
ISSN: 2297-1769
Titre abrégé: Front Vet Sci
Pays: Switzerland
ID NLM: 101666658
Informations de publication
Date de publication:
2021
2021
Historique:
received:
16
12
2020
accepted:
11
02
2021
entrez:
29
4
2021
pubmed:
30
4
2021
medline:
30
4
2021
Statut:
epublish
Résumé
Aleurone, a layer of the bran fraction, is deemed to be responsible for the positive health effects associated with the consumption of whole-grain products. Studies on rodents, pigs, and humans report beneficial effects of aleurone in five main areas: the reduction of oxidative stress, immunomodulatory effects, modulation of energy management, digestive health, and the storage of vitamins and minerals. Our study is the first aleurone supplementation study performed in horses. The aim of this study was to investigate the effect of an increase in the dose levels of aleurone on the postprandial glucose-insulin metabolism and the gut microbiome in untrained healthy horses. Seven adult Standardbred horses were supplemented with four different dose levels of aleurone (50, 100, 200, and 400 g/day for 1 week) by using a Latin square model with a 1-week wash out in between doses. On day 7 of each supplementation week, postprandial blood glucose-insulin was measured and fecal samples were collected. 16S ribosomal RNA (rRNA) gene sequencing was performed and QIIME2 software was used for microbiome analysis. Microbial community function was assessed by using the predictive metagenome analysis tool Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) and using the Metacyc database of metabolic pathways. The relative abundancies of a pathway were analyzed by using analysis of composition of microbiomes (ANCOM) in R. There was a significant dose-dependent increase in the postprandial time to peak of glucose (
Identifiants
pubmed: 33912605
doi: 10.3389/fvets.2021.642809
pmc: PMC8072273
doi:
Types de publication
Journal Article
Langues
eng
Pagination
642809Informations de copyright
Copyright © 2021 Boshuizen, Moreno de Vega, De Maré, de Meeûs, de Oliveira, Hosotani, Gansemans, Deforce, Van Nieuwerburgh and Delesalle.
Déclaration de conflit d'intérêts
JO and GH are employed by Cargill R&D Centre Europe. Cargill has exclusivity over distribution of aleurone for feed market in Europe produced according to patents held by Buhler Company. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Biosci Bioeng. 2018 May;125(5):519-524
pubmed: 29331526
Diabetes Metab. 2005 Sep;31(4 Pt 1):337-44
pubmed: 16369195
Nucleic Acids Res. 2013 Jan 7;41(1):e1
pubmed: 22933715
Cardiovasc Drug Rev. 2005 Summer;23(2):161-72
pubmed: 16007232
Eur J Clin Nutr. 2007 Mar;61(3):334-41
pubmed: 16988651
Equine Vet J. 2015 Nov;47(6):641-9
pubmed: 25257320
J Agric Food Chem. 2003 Aug 27;51(18):5534-9
pubmed: 12926910
J Gerontol A Biol Sci Med Sci. 2005 Oct;60(10):1252-64
pubmed: 16282556
PLoS One. 2016 Dec 9;11(12):e0167108
pubmed: 27935992
PLoS One. 2014 Nov 10;9(11):e112846
pubmed: 25383707
Amino Acids. 2015 Apr;47(4):839-46
pubmed: 25577261
Equine Vet J. 2009 Dec;41(9):908-14
pubmed: 20383990
J Neurochem. 2019 Jun;149(5):641-659
pubmed: 31006109
J Cereal Sci. 2007;46(1):93-95
pubmed: 19030121
Exp Gerontol. 2013 May;48(5):517-24
pubmed: 23466300
Nucleic Acids Res. 2020 Jan 8;48(D1):D445-D453
pubmed: 31586394
Meat Sci. 2011 Jul;88(3):525-30
pubmed: 21388750
Sports Med. 2017 Mar;47(3):415-428
pubmed: 27459862
Anim Nutr. 2018 Jun;4(2):151-159
pubmed: 30140754
Appl Environ Microbiol. 1988 Sep;54(9):2155-60
pubmed: 3190223
Molecules. 2015 Aug 28;20(9):15666-85
pubmed: 26343624
Genet Mol Res. 2014 Sep 12;13(3):7577-86
pubmed: 25222258
Biochim Biophys Acta. 2010 Nov;1801(11):1175-83
pubmed: 20691280
Nutr Metab (Lond). 2014 Jan 02;11(1):1
pubmed: 24383425
J Agric Food Chem. 2010 Feb 10;58(3):2001-7
pubmed: 19954215
Animal. 2020 Mar;14(3):508-519
pubmed: 31609193
Equine Vet J Suppl. 2006 Aug;(36):579-84
pubmed: 17402487
Nutr Metab Cardiovasc Dis. 2009 Dec;19(11):767-73
pubmed: 19346114
Br J Nutr. 2011 Feb;105(3):373-83
pubmed: 20923581
Mol Nutr Food Res. 2019 Apr;63(7):e1800959
pubmed: 30636184
Food Funct. 2019 Aug 1;10(8):4674-4684
pubmed: 31292590
Am J Clin Nutr. 2006 Jul;84(1):252-62
pubmed: 16825703
Appl Environ Microbiol. 2006 Jul;72(7):5069-72
pubmed: 16820507
Trends Plant Sci. 2000 Mar;5(3):102-10
pubmed: 10707075
J Biomed Sci. 2010 Aug 24;17 Suppl 1:S11
pubmed: 20804585
BMJ. 2020 Jul 8;370:m2206
pubmed: 32641435
BMC Vet Res. 2020 Mar 4;16(1):78
pubmed: 32131835
Br J Nutr. 2018 Dec 20;:1-33
pubmed: 30567621
Food Chem. 2008 Aug 15;109(4):691-702
pubmed: 26049981
J Agric Food Chem. 2009 Jul 22;57(14):6148-55
pubmed: 19537710
J Agric Food Chem. 2007 May 30;55(11):4589-95
pubmed: 17488118
Diabetes. 2009 Jul;58(7):1509-17
pubmed: 19366864
J Nutr. 2008 May;138(5):914-20
pubmed: 18424601
J Nutr. 2006 Jun;136(6):1511-6
pubmed: 16702313
Am J Clin Nutr. 2020 Apr 1;111(4):864-876
pubmed: 32097450
J Agric Food Chem. 2001 Nov;49(11):5679-84
pubmed: 11714377
Food Funct. 2014 Mar;5(3):579-86
pubmed: 24500609
Plant Physiol. 2001 May;126(1):156-66
pubmed: 11351079
Am J Transl Res. 2016 Dec 15;8(12):5672-5684
pubmed: 28078038
Clin Exp Pharmacol Physiol. 2016 Feb;43(2):242-50
pubmed: 26541794
J Agric Food Chem. 2005 Jun 15;53(12):5030-5
pubmed: 15941352
J Nutr. 2002 Jul;132(7):1962-8
pubmed: 12097677
Nutrition. 2017 Jan;33:28-34
pubmed: 27908547
Free Radic Biol Med. 1992 Oct;13(4):435-48
pubmed: 1398220
PLoS One. 2020 Mar 19;15(3):e0230015
pubmed: 32191712
Exp Mol Med. 2012 Nov 30;44(11):665-73
pubmed: 23114424
Clin Biochem. 2010 Jun;43(9):732-44
pubmed: 20346934
Cell Host Microbe. 2008 Apr 17;3(4):213-23
pubmed: 18407065
Am J Vet Res. 2018 Aug;79(8):811-819
pubmed: 30058849
Nature. 2009 Jan 22;457(7228):480-4
pubmed: 19043404
Microb Ecol Health Dis. 2015 May 29;26:27663
pubmed: 26028277
J Agric Food Chem. 2014 Oct 15;62(41):10101-9
pubmed: 25238637
Am J Epidemiol. 2018 Sep 1;187(9):1916-1922
pubmed: 29800124
Eur J Appl Physiol. 2013 Mar;113(3):793-802
pubmed: 22976217
Br J Nutr. 2010 Feb;103(3):360-9
pubmed: 19732471
J Diet Suppl. 2016 Nov;13(6):626-33
pubmed: 27049812
J Anim Sci. 1976 Jun;42(6):1465-70
pubmed: 931822
Br J Nutr. 2010 Oct;104(8):1101-11
pubmed: 20579402
J Agric Food Chem. 2006 Feb 22;54(4):1256-64
pubmed: 16478245
Nutrients. 2018 Jan 26;10(2):
pubmed: 29373534
J Vet Intern Med. 2019 Mar;33(2):335-349
pubmed: 30724412
Nutrients. 2018 Nov 01;10(11):
pubmed: 30388881
Mol Biol Rep. 2011 Mar;38(3):1975-81
pubmed: 20845073
J Clin Endocrinol Metab. 2018 Aug 1;103(8):3038-3049
pubmed: 29860335
J Agric Food Chem. 2012 Dec 19;60(50):12312-23
pubmed: 23157164
J Agric Food Chem. 2008 Jul 23;56(14):5589-94
pubmed: 18558703
Vet J. 2015 Jul;205(1):74-80
pubmed: 25975855
J Nutr. 2010 Dec;140(12):2153-7
pubmed: 20980654
J Nutr. 2019 Dec 1;149(12):2133-2144
pubmed: 31504709
Br J Nutr. 2015 Jun 28;113(12):1835-43
pubmed: 25920593
Br J Nutr. 1987 Jan;57(1):69-76
pubmed: 3026436
BMC Res Notes. 2013 Mar 12;6:91
pubmed: 23497580
Lett Appl Microbiol. 2019 Feb;68(2):142-148
pubmed: 30444534
Equine Vet J Suppl. 2006 Aug;(36):226-32
pubmed: 17402423
J Anim Sci. 1999 Mar;77(3):677-84
pubmed: 10229364
Nutr Rev. 2004 Mar;62(3):81-95
pubmed: 15098855
Nat Biotechnol. 2013 Sep;31(9):814-21
pubmed: 23975157
Br J Nutr. 2014 May;111(9):1564-76
pubmed: 24507768
Am J Clin Nutr. 2018 Nov 1;108(5):971-979
pubmed: 30256894
Vet Clin North Am Equine Pract. 2009 Apr;25(1):51-65, vi
pubmed: 19303550
Nature. 2016 Jul 21;535(7612):376-81
pubmed: 27409811
J Agric Food Chem. 2013 Aug 14;61(32):7760-8
pubmed: 23919413
J Nutr Biochem. 2014 Mar;25(3):353-62
pubmed: 24456735
Nat Methods. 2010 May;7(5):335-6
pubmed: 20383131
Food Nutr Res. 2017 Aug 23;61(1):1361778
pubmed: 28970776
Mol Nutr Food Res. 2017 Jul;61(7):
pubmed: 28155258
Front Horm Res. 2016;47:44-57
pubmed: 27348753
Anim Microbiome. 2019 Nov 13;1(1):14
pubmed: 33499951
Int Immunopharmacol. 2008 Oct;8(10):1423-32
pubmed: 18687304
Br J Nutr. 2015 Feb 14;113(3):445-53
pubmed: 25585164
J Int Soc Sports Nutr. 2010 Jul 19;7:27
pubmed: 20642826
Equine Vet J. 2015 Sep;47(5):580-6
pubmed: 25041526
J Agric Food Chem. 2008 Nov 12;56(21):9732-9
pubmed: 18921977
Front Microbiol. 2017 Aug 11;8:1502
pubmed: 28848517
J Exp Biol. 2020 Apr 1;223(Pt 7):
pubmed: 32098884
Br J Nutr. 2010 Jan;103(1):82-90
pubmed: 19664300
J Agric Food Chem. 2018 Jun 27;66(25):6326-6335
pubmed: 29766722