Rituximab in Membranous Nephropathy.
B cells
membranous nephropathy
nephrotic syndrome
rituximab
Journal
Kidney international reports
ISSN: 2468-0249
Titre abrégé: Kidney Int Rep
Pays: United States
ID NLM: 101684752
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
23
09
2020
revised:
28
12
2020
accepted:
29
12
2020
entrez:
29
4
2021
pubmed:
30
4
2021
medline:
30
4
2021
Statut:
epublish
Résumé
Membranous nephropathy (MN) is the most common cause of primary nephrotic syndrome among adults. The identification of phospholipase A2 receptor (PLA2R) as target antigen in most patients changed the management of MN dramatically, and provided a rationale for B-cell depleting agents such as rituximab. The efficacy of rituximab in inducing remission has been investigated in several studies, including 3 randomized controlled trials, in which complete and partial remission of proteinuria was achieved in approximately two-thirds of treated patients. Due to its favorable safety profile, rituximab is now considered a first-line treatment option for MN, especially in patients at moderate and high risk of deterioration in kidney function. However, questions remain about how to best use rituximab, including the optimal dosing regimen, a potential need for maintenance therapy, and assessment of long-term safety and efficacy outcomes. In this review, we provide an overview of the current literature and discuss both strengths and limitations of "the new standard."
Identifiants
pubmed: 33912740
doi: 10.1016/j.ekir.2020.12.035
pii: S2468-0249(20)31869-6
pmc: PMC8071613
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
881-893Investigateurs
Philipp Gauckler
(P)
Jae Il Shin
(JI)
Federico Alberici
(F)
Vincent Audard
(V)
Annette Bruchfeld
(A)
Martin Busch
(M)
Chee Kay Cheung
(CK)
Matija Crnogorac
(M)
Elisa Delbarba
(E)
Kathrin Eller
(K)
Stanislas Faguer
(S)
Kresimir Galesic
(K)
Siân Griffin
(S)
Martijn Wf van den Hoogen
(MW)
Zdenka Hrušková
(Z)
Anushya Jeyabalan
(A)
Alexandre Karras
(A)
Catherine King
(C)
Harbir Singh Kohli
(HS)
Gert Mayer
(G)
Rutger Maas
(R)
Masahiro Muto
(M)
Sergey Moiseev
(S)
Balazs Odler
(B)
Ruth J Pepper
(RJ)
Luis F Quintana
(LF)
Jai Radhakrishnan
(J)
Raja Ramachandran
(R)
Alan D Salama
(AD)
Ulf Schönermarck
(U)
Mårten Segelmark
(M)
Lee Smith
(L)
Vladimír Tesař
(V)
Jack Wetzels
(J)
Lisa Willcocks
(L)
Martin Windpessl
(M)
Ladan Zand
(L)
Reza Zonozi
(R)
Andreas Kronbichler
(A)
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2021 Published by Elsevier, Inc., on behalf of the International Society of Nephrology.
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