Early Posttransplant Blood Transfusion and Risk for Worse Graft Outcomes.
donor-specific antibodies
kidney transplant
rejection
transfusion
Journal
Kidney international reports
ISSN: 2468-0249
Titre abrégé: Kidney Int Rep
Pays: United States
ID NLM: 101684752
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
27
02
2020
revised:
14
12
2020
accepted:
30
12
2020
entrez:
29
4
2021
pubmed:
30
4
2021
medline:
30
4
2021
Statut:
epublish
Résumé
Blood transfusion is a risk factor for allosensitization. Nevertheless, blood transfusion posttransplant remains a common practice. We evaluated the effect of posttransplant blood transfusion on graft outcomes. We included nonsensitized, first-time, kidney-alone recipients transplanted between 1 July 2015 and 31 December 2017. Patients were grouped based on receiving blood transfusion in the first 30 days posttransplant. The primary end point was a composite outcome of biopsy-proven acute rejection, death of any cause, or graft failure in the first year posttransplant. Secondary outcomes included the individual components of the primary outcome and the cumulative incidence of Two hundred seventy-three patients were included. One hundred twenty-seven (47%) received blood transfusion. Patients in the transfusion group were more likely to be older, have had a deceased donor, and have received induction with basiliximab. There was no difference between groups in the composite primary outcome (adjusted hazard ratio = [HR] 1.34; 95% confidence interval [CI], 0.83-2.17; Early transfusion of blood products in kidney transplant recipients receiving induction with lymphocyte depletion was not associated with an increased hazard of experiencing acute rejection, death from any cause, or graft loss.
Identifiants
pubmed: 33912748
doi: 10.1016/j.ekir.2020.12.038
pii: S2468-0249(21)00007-3
pmc: PMC8071616
doi:
Types de publication
Journal Article
Langues
eng
Pagination
986-994Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2021 International Society of Nephrology. Published by Elsevier Inc.
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