Reduction of host cell mitochondrial activity as Mycobacterium leprae's strategy to evade host innate immunity.
HIF-1α
LACC1
PKRN
cholesterol
free fatty acid and xenophagy
immunometabolism
inflammasome
leprosy
parkin
Journal
Immunological reviews
ISSN: 1600-065X
Titre abrégé: Immunol Rev
Pays: England
ID NLM: 7702118
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
09
02
2021
received:
08
01
2021
accepted:
10
02
2021
pubmed:
30
4
2021
medline:
26
10
2021
entrez:
29
4
2021
Statut:
ppublish
Résumé
Leprosy is a much-feared incapacitating infectious disease caused by Mycobacterium leprae or M lepromatosis, annually affecting roughly 200,000 people worldwide. During host-pathogen interaction, M leprae subverts the immune response, leading to development of disease. Throughout the last few decades, the impact of energy metabolism on the control of intracellular pathogens and leukocytic differentiation has become more evident. Mitochondria play a key role in regulating newly-discovered immune signaling pathways by controlling redox metabolism and the flow of energy besides activating inflammasome, xenophagy, and apoptosis. Likewise, this organelle, whose origin is probably an alphaproteobacterium, directly controls the intracellular pathogens attempting to invade its niche, a feature conquered at the expense of billions of years of coevolution. In the present review, we discuss the role of reduced host cell mitochondrial activity during M leprae infection and the consequential fates of M leprae and host innate immunity. Conceivably, inhibition of mitochondrial energy metabolism emerges as an overlooked and novel mechanism developed by M leprae to evade xenophagy and the host immune response.
Identifiants
pubmed: 33913182
doi: 10.1111/imr.12962
pmc: PMC10084840
mid: NIHMS1677126
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
193-208Subventions
Organisme : NIAID NIH HHS
ID : R01 AI141526
Pays : United States
Informations de copyright
© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Références
Clin Microbiol Rev. 2006 Apr;19(2):338-81
pubmed: 16614253
Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11715-20
pubmed: 9751731
Am J Physiol. 1993 Feb;264(2 Pt 1):C383-9
pubmed: 8383431
Nature. 2009 May 21;459(7245):433-6
pubmed: 19339971
J Bacteriol. 2007 Jul;189(13):4578-86
pubmed: 17483224
Cell. 2008 Jul 11;134(1):112-23
pubmed: 18614015
J Biol Chem. 1966 Feb 10;241(3):632-4
pubmed: 4222257
FEBS J. 2016 Mar;283(5):822-33
pubmed: 26732506
Adv Exp Med Biol. 2012;748:145-69
pubmed: 22729857
PLoS Negl Trop Dis. 2011 Mar 15;5(3):e1013
pubmed: 21423643
Am J Hum Genet. 2018 May 3;102(5):794-805
pubmed: 29706348
Annu Rev Biochem. 1997;66:717-49
pubmed: 9242922
Am J Transl Res. 2018 Sep 15;10(9):2929-2939
pubmed: 30323879
Cell Microbiol. 2010 Jan;12(1):42-54
pubmed: 19732058
Dev Cell. 2001 Oct;1(4):515-25
pubmed: 11703942
J Cell Biol. 2010 Apr 19;189(2):211-21
pubmed: 20404107
Nature. 2014 Nov 20;515(7527):431-435
pubmed: 25383517
Nat Cell Biol. 2017 Sep;19(9):1027-1036
pubmed: 28812582
Sci Rep. 2017 Mar 10;7:44373
pubmed: 28281653
Nat Rev Immunol. 2017 Oct;17(10):608-620
pubmed: 28669986
Nat Rev Mol Cell Biol. 2011 Jan;12(1):9-14
pubmed: 21179058
Nat Rev Immunol. 2019 May;19(5):291-304
pubmed: 30679807
Nature. 2006 Mar 9;440(7081):237-41
pubmed: 16407889
Cell Host Microbe. 2009 Oct 22;6(4):343-53
pubmed: 19837374
Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15616-15624
pubmed: 31308240
Immunity. 2015 Mar 17;42(3):419-30
pubmed: 25786174
Nature. 2013 Sep 26;501(7468):512-6
pubmed: 24005326
Science. 2005 May 13;308(5724):1040-2
pubmed: 15894530
Mem Inst Oswaldo Cruz. 2012 Dec;107 Suppl 1:156-66
pubmed: 23283467
FEBS Lett. 1981 Dec 7;135(2):249-52
pubmed: 6274693
Cell. 1996 Jul 12;86(1):147-57
pubmed: 8689682
Mem Inst Oswaldo Cruz. 2010 Aug;105(5):627-32
pubmed: 20835608
J Immunol. 2017 Apr 1;198(7):2854-2864
pubmed: 28235862
J Neurochem. 1974 Mar;22(3):395-401
pubmed: 4364341
Nat Immunol. 2011 Mar;12(3):222-30
pubmed: 21151103
Nature. 2013 Apr 11;496(7444):238-42
pubmed: 23535595
Cell Metab. 2018 Apr 3;27(4):869-885.e6
pubmed: 29617645
PLoS One. 2014 Aug 26;9(8):e103743
pubmed: 25157633
Mol Cell. 2008 May 23;30(4):393-402
pubmed: 18498744
J Cell Biol. 2003 Jan 20;160(2):189-200
pubmed: 12527753
Nat Commun. 2020 Jan 3;11(1):102
pubmed: 31900386
Annu Rev Cell Dev Biol. 2012;28:137-61
pubmed: 22974247
J Biol Chem. 2012 Oct 19;287(43):36617-22
pubmed: 22948162
Eur J Biochem. 1996 Jul 15;239(2):445-50
pubmed: 8706753
PLoS Pathog. 2019 Jun 24;15(6):e1007887
pubmed: 31233552
Elife. 2020 Aug 14;9:
pubmed: 32795388
Eur J Hum Genet. 2006 Apr;14(4):438-42
pubmed: 16391553
Cell Metab. 2013 Apr 2;17(4):491-506
pubmed: 23562075
Nature. 2006 Mar 9;440(7081):228-32
pubmed: 16407890
F1000Res. 2020 Jan 31;9:
pubmed: 32051758
J Biol Chem. 2011 Dec 9;286(49):42534-42544
pubmed: 21859708
PLoS One. 2013 Jun 14;8(6):e64748
pubmed: 23798993
Placenta. 2018 Mar;63:26-31
pubmed: 29486853
Front Cell Infect Microbiol. 2020 Sep 30;10:457
pubmed: 33102245
J Bacteriol. 2015 Dec;197(23):3698-707
pubmed: 26391209
PLoS Genet. 2017 Aug 9;13(8):e1006952
pubmed: 28793313
Immunity. 2013 Jun 27;38(6):1142-53
pubmed: 23809161
Nat Cell Biol. 2012 Jan 22;14(2):177-85
pubmed: 22267086
Trends Cell Biol. 2016 Jan;26(1):6-16
pubmed: 26437584
Front Immunol. 2016 Dec 01;7:557
pubmed: 27990145
Immunity. 2015 Mar 17;42(3):393-4
pubmed: 25786167
Trends Biochem Sci. 2016 Dec;41(12):1012-1021
pubmed: 27669650
J Infect Dis. 2016 Jul 15;214(2):311-20
pubmed: 27190175
J Exp Med. 1996 Oct 1;184(4):1331-41
pubmed: 8879205
Nat Commun. 2015 Mar 24;6:6555
pubmed: 25800347
Nat Rev Immunol. 2019 May;19(5):273-281
pubmed: 30705422
Lepr India. 1980 Jul;52(3):374-82
pubmed: 7206634
PLoS Pathog. 2017 Jan 5;13(1):e1006103
pubmed: 28056107
Nature. 1961 Jul 8;191:144-8
pubmed: 13771349
J Biol Chem. 2014 Sep 26;289(39):27159-27168
pubmed: 25138219
J Leukoc Biol. 2010 Mar;87(3):371-84
pubmed: 19952355
Indian J Lepr. 1985 Jul-Sep;57(3):524-8
pubmed: 3831088
Nature. 2001 Feb 22;409(6823):1007-11
pubmed: 11234002
Nature. 2004 Feb 12;427(6975):636-40
pubmed: 14737177
Mol Cell. 2013 Jan 24;49(2):331-8
pubmed: 23246432
Cell Microbiol. 2020 Jan;22(1):e13128
pubmed: 31652371
J Leukoc Biol. 2018 Jan;103(1):35-51
pubmed: 29345056
J Cell Biol. 2008 Dec 1;183(5):795-803
pubmed: 19029340
Lepr Rev. 2004 Dec;75(4):310-26
pubmed: 15682969
Eur J Biochem. 1973 Sep 3;37(3):523-30
pubmed: 4777251
Science. 1985 Dec 20;230(4732):1350-4
pubmed: 2999980
Mucosal Immunol. 2019 Sep;12(5):1150-1163
pubmed: 31152156
Biochem J. 1972 Aug;128(5):1125-33
pubmed: 4643697
Cold Spring Harb Perspect Biol. 2014 Oct 30;7(2):a016311
pubmed: 25359497
Nature. 2018 Feb 15;554(7692):382-386
pubmed: 29364868
PLoS Biol. 2018 Jan 25;16(1):e2003992
pubmed: 29370167
Cell Death Differ. 2008 Apr;15(4):660-6
pubmed: 18219320
Science. 2017 Nov 3;358(6363):623-630
pubmed: 29097544
Nat Immunol. 2016 Sep;17(9):1046-56
pubmed: 27478939
J Biol Chem. 1949 Jun;179(2):957-72
pubmed: 18150026
Cell Microbiol. 2011 Feb;13(2):259-73
pubmed: 20955239
J Clin Microbiol. 1988 Jun;26(6):1124-9
pubmed: 3290244
Nature. 1998 Jun 11;393(6685):537-44
pubmed: 9634230
IUBMB Life. 2000 May;49(5):365-73
pubmed: 10902567
N Engl J Med. 2009 Dec 31;361(27):2609-18
pubmed: 20018961
J Biol Chem. 1948 Feb;172(2):619-35
pubmed: 18901182
Nat Med. 2011 Feb;17(2):200-5
pubmed: 21258337
Front Physiol. 2018 Sep 20;9:1172
pubmed: 30294276
J Infect Dis. 2006 Feb 1;193(3):346-53
pubmed: 16388481
PLoS Biol. 2010 Jan 26;8(1):e1000298
pubmed: 20126261
Front Immunol. 2018 Jun 04;9:1223
pubmed: 29915584
Trends Immunol. 2017 Jun;38(6):395-406
pubmed: 28396078
Annu Rev Physiol. 1966;28:435-92
pubmed: 5322983
Nat Med. 2015 Jul;21(7):677-87
pubmed: 26121197
Curr Pharm Des. 2009;15(36):4103-16
pubmed: 20041812
J Biol Chem. 2016 Oct 7;291(41):21375-21387
pubmed: 27555322
Mol Genet Genomics. 2020 Nov;295(6):1355-1368
pubmed: 32661593
Oxid Med Cell Longev. 2017;2017:3496043
pubmed: 28255425
Immunity. 2012 Mar 23;36(3):401-14
pubmed: 22342844
Cell Mol Life Sci. 2019 May;76(9):1759-1777
pubmed: 30767037
Nat Immunol. 2014 Apr;15(4):323-32
pubmed: 24562310
FEBS Lett. 2003 Feb 11;536(1-3):1-2
pubmed: 12586327
J Exp Med. 2018 Jan 2;215(1):357-375
pubmed: 29247046
Biochem J. 1973 Jul;134(3):707-16
pubmed: 4749271
Front Immunol. 2018 Apr 23;9:806
pubmed: 29755459
Hum Mol Genet. 2011 May 1;20(9):1726-37
pubmed: 21296869
Mem Inst Oswaldo Cruz. 2020 Feb 27;115:e190324
pubmed: 32130367
PLoS Negl Trop Dis. 2013 Aug 15;7(8):e2381
pubmed: 23967366
Proc Natl Acad Sci U S A. 2013 May 7;110(19):7820-5
pubmed: 23610393
Free Radic Biol Med. 2004 Jun 1;36(11):1460-70
pubmed: 15135183
J Cell Biol. 2017 Apr 3;216(4):1091-1105
pubmed: 28254829
PLoS Pathog. 2011 Dec;7(12):e1002435
pubmed: 22174691
Biochim Biophys Acta. 2000 Dec 15;1529(1-3):175-87
pubmed: 11111087
Nat Rev Immunol. 2017 Jun;17(6):363-375
pubmed: 28393922
Autophagy. 2020 Feb;16(2):203-222
pubmed: 30945962
J Biol Chem. 2015 Jan 2;290(1):46-55
pubmed: 25406319
Cardiovasc Res. 2014 Sep 1;103(4):619-28
pubmed: 24776598
Biochim Biophys Acta. 2006 May-Jun;1757(5-6):686-91
pubmed: 16712778
Nat Rev Mol Cell Biol. 2018 Feb;19(2):121-135
pubmed: 28974774
Cell. 2017 Aug 24;170(5):973-985.e10
pubmed: 28841420
Curr Protoc Immunol. 2009 Apr;Chapter 7:7.1.1-7.1.8
pubmed: 19347849
Proc Natl Acad Sci U S A. 1973 Oct;70(10):2837-9
pubmed: 4517936
Mol Cell. 2014 Nov 6;56(3):425-435
pubmed: 25458843
Science. 2011 Oct 21;334(6054):358-62
pubmed: 21885730
Science. 2019 Mar 15;363(6432):
pubmed: 30872492
Cell Microbiol. 2014 Jun;16(6):797-815
pubmed: 24552180
J Bioenerg Biomembr. 2013 Feb;45(1-2):87-99
pubmed: 23080405
Nat Rev Dis Primers. 2016 Oct 20;2:16080
pubmed: 27775730
Clin Transl Med. 2016 Dec;5(1):22
pubmed: 27455839
Eur J Hum Genet. 2012 May;20(5):488-9
pubmed: 22009144
BMC Microbiol. 2006 Sep 18;6:78
pubmed: 16978419
Nature. 2011 Jan 13;469(7329):221-5
pubmed: 21124315
Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):378-83
pubmed: 19966284
J Mass Spectrom. 2015 Dec;50(12):1374-85
pubmed: 26634971
J Infect Dis. 2010 Jun 1;201(11):1736-42
pubmed: 20402595
Antimicrob Agents Chemother. 2014 Oct;58(10):5766-74
pubmed: 25049257
Nature. 2010 Mar 4;464(7285):104-7
pubmed: 20203610
Cell. 2016 Oct 6;167(2):457-470.e13
pubmed: 27667687
Elife. 2020 Feb 14;9:
pubmed: 32057291
Biochem J. 2016 Apr 1;473(7):929-36
pubmed: 26831515
Nat Neurosci. 2000 Dec;3(12):1301-6
pubmed: 11100151