Structural and biological aspects of natural bridged macrobicyclic peptides from marine resources.
antifungal activity
bridged macrobicyclic peptides
cytotoxic activity
peptide syntheses
substituent effect
Journal
Archiv der Pharmazie
ISSN: 1521-4184
Titre abrégé: Arch Pharm (Weinheim)
Pays: Germany
ID NLM: 0330167
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
revised:
03
04
2021
received:
24
01
2021
accepted:
06
04
2021
pubmed:
30
4
2021
medline:
31
12
2021
entrez:
29
4
2021
Statut:
ppublish
Résumé
Among peptide-based drugs, naturally occurring bicyclic compounds have been established as molecules with unique therapeutic potential. The diverse pharmacological activities associated with bicyclic peptides from marine tunicates, sponges, and bacteria render them suitable to be employed as effective surrogate between complex and small therapeutic moieties. Bicyclic peptides possess greater conformational rigidity and higher metabolic stability as compared with linear and monocyclic peptides. The antibody-like affinity and specificity of bicyclic peptides enable their binding to the challenging drug targets. Bridged macrobicyclic peptides from natural marine resources represent an underexplored class of molecules that provides promising platforms for drug development owing to their biocompatibility, similarity, and chemical diversity to proteins. The present review explores major marine-derived bicyclic peptides including disulfide-bridged, histidinotyrosine-bridged, or histidinoalanine-bridged macrobicyclic peptides along with their structural characteristics, synthesis, structure-activity relationship, and bioproperties.The comparison of these macrobicyclic congeners with linear/monocyclic peptides along with their therapeutic potential are also briefly discussed.
Identifiants
pubmed: 33913195
doi: 10.1002/ardp.202100034
doi:
Substances chimiques
Biological Products
0
Peptides, Cyclic
0
Types de publication
Comparative Study
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2100034Informations de copyright
© 2021 Deutsche Pharmazeutische Gesellschaft.
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