Plant-Derived Natural Compounds for the Treatment of Amyotrophic Lateral Sclerosis: An Update.
CNS disorders
Plant-derived products
SAR
SOD1 mutations
Therapeutic effects
clinical trials
Journal
Current neuropharmacology
ISSN: 1875-6190
Titre abrégé: Curr Neuropharmacol
Pays: United Arab Emirates
ID NLM: 101157239
Informations de publication
Date de publication:
2022
2022
Historique:
received:
03
12
2020
revised:
14
03
2021
accepted:
16
04
2021
pubmed:
30
4
2021
medline:
27
1
2022
entrez:
29
4
2021
Statut:
ppublish
Résumé
Amyotrophic lateral sclerosis (ALS) is a motor neuron disease (MND) that typically causes death within 3-5 years after diagnosis. Regardless of the substantial scientific knowledge accrued more than a century ago, truly effective therapeutic strategies remain distant. Various conventional drugs are being used but are having several adverse effects. The current study aims to thoroughly review plant-derived compounds with welldefined ALS activities and their structure-activity relationships. Moreover, the review also focuses on complex genetics, clinical trials, and the use of natural products that might decrypt the future and novel therapeutics in ALS. The collection of data for the compilation of this review work was searched in PubMed Scopus, Google Scholar, and Science Direct. Results showed that phytochemicals like-Ginkgolides, Protopanaxatriol, Genistein, epigallocatechingallate, resveratrol, cassoside, and others possess Amyotrophic lateral sclerosis (ALS) activity by various mechanisms Conclusion: These plant-derived compounds may be considered as supplements for conventional (ALS). Moreover, further preclinical and clinical studies are required to understand the structureactivity relationships, metabolism, absorption, and mechanisms of plant-derived natural agents.
Sections du résumé
BACKGROUND
BACKGROUND
Amyotrophic lateral sclerosis (ALS) is a motor neuron disease (MND) that typically causes death within 3-5 years after diagnosis. Regardless of the substantial scientific knowledge accrued more than a century ago, truly effective therapeutic strategies remain distant. Various conventional drugs are being used but are having several adverse effects.
OBJECTIVE/AIM
OBJECTIVE
The current study aims to thoroughly review plant-derived compounds with welldefined ALS activities and their structure-activity relationships. Moreover, the review also focuses on complex genetics, clinical trials, and the use of natural products that might decrypt the future and novel therapeutics in ALS.
METHODS
METHODS
The collection of data for the compilation of this review work was searched in PubMed Scopus, Google Scholar, and Science Direct.
RESULTS
RESULTS
Results showed that phytochemicals like-Ginkgolides, Protopanaxatriol, Genistein, epigallocatechingallate, resveratrol, cassoside, and others possess Amyotrophic lateral sclerosis (ALS) activity by various mechanisms Conclusion: These plant-derived compounds may be considered as supplements for conventional (ALS). Moreover, further preclinical and clinical studies are required to understand the structureactivity relationships, metabolism, absorption, and mechanisms of plant-derived natural agents.
Identifiants
pubmed: 33913406
pii: CN-EPUB-115508
doi: 10.2174/1570159X19666210428120514
pmc: PMC9199545
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
179-193Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
Références
Nat Rev Neurol. 2013 Nov;9(11):617-28
pubmed: 24126629
Amyotroph Lateral Scler Frontotemporal Degener. 2013 May;14(4):278-83
pubmed: 23286747
Neurosci Lett. 2011 Oct 10;503(3):250-5
pubmed: 21896316
Br J Pharmacol. 2010 Apr;159(8):1646-62
pubmed: 20397299
Biomed Res Int. 2019 Apr 7;2019:8748253
pubmed: 31080832
Cell Mol Neurobiol. 2010 Oct;30(7):1059-66
pubmed: 20577899
Phytother Res. 2012 Jul;26(7):988-94
pubmed: 22144097
Biofactors. 2004;21(1-4):175-8
pubmed: 15630194
J Cell Physiol. 2017 Aug;232(8):2145-2157
pubmed: 27891586
Neurol Res. 2009 Feb;31(1):23-7
pubmed: 18768114
Cell Stress Chaperones. 2016 Sep;21(5):837-48
pubmed: 27273088
Orphanet J Rare Dis. 2014 May 21;9:78
pubmed: 24885036
Brain Res. 2011 Feb 16;1374:110-5
pubmed: 21147075
Curr Med Chem. 2011;18(36):5655-65
pubmed: 22172070
FASEB J. 2003 Oct;17(13):1943-4
pubmed: 12897065
Eur J Pharmacol. 2009 Jun 24;613(1-3):19-23
pubmed: 19379729
Cell Calcium. 2013 Aug;54(2):132-43
pubmed: 23764168
Int J Mol Sci. 2020 Jan 24;21(3):
pubmed: 31991572
Neuroreport. 2005 Apr 25;16(6):527-31
pubmed: 15812300
Oxid Med Cell Longev. 2016;2016:8378613
pubmed: 26881043
Toxicon. 2001 May;39(5):603-13
pubmed: 11072038
Expert Opin Drug Discov. 2018 Jul;13(7):627-641
pubmed: 29676181
Naunyn Schmiedebergs Arch Pharmacol. 2010 Jan;381(1):73-81
pubmed: 19936711
Biomed Pharmacother. 2017 Dec;96:854-864
pubmed: 29078263
Zhongguo Zhong Yao Za Zhi. 2009 Jul;34(13):1701-4
pubmed: 19873786
Am J Hypertens. 2010 Sep;23(9):936; author reply 937
pubmed: 20733571
Neuroscience. 2014 Jul 11;272:141-53
pubmed: 24785678
Neurodegener Dis. 2005;2(5):246-54
pubmed: 16909005
J Neurol Neurosurg Psychiatry. 2005 Aug;76(8):1046-57
pubmed: 16024877
Neuro Endocrinol Lett. 2018 Feb;38(8):528-531
pubmed: 29504729
Eur J Neurol. 2008 Nov;15(11):1245-51
pubmed: 18973614
Drug Discov Today. 2015 Jan;20(1):65-75
pubmed: 25205348
J Neurol Neurosurg Psychiatry. 2011 Jun;82(6):623-7
pubmed: 21047878
Neurotox Res. 2008 Jan;13(1):49-61
pubmed: 18367440
Nat Rev Neurosci. 2013 Apr;14(4):248-64
pubmed: 23463272
Neurosci Lett. 2019 Sep 14;709:134386
pubmed: 31330225
Int J Mol Med. 2017 Mar;39(3):603-612
pubmed: 28204825
J Pharmacol Exp Ther. 2006 Oct;319(1):165-80
pubmed: 16840647
Neuroepidemiology. 2013;40(2):133-41
pubmed: 23095852
Planta Med. 2011 Oct;77(15):1695-701
pubmed: 21509715
Comb Chem High Throughput Screen. 2021;24(5):624-644
pubmed: 33143603
Nutr Neurosci. 2022 Mar;25(3):441-461
pubmed: 32441587
Amyotroph Lateral Scler Frontotemporal Degener. 2018 Nov;19(7-8):623-629
pubmed: 29493344
Molecules. 2019 Apr 22;24(8):
pubmed: 31013638
Beijing Da Xue Xue Bao Yi Xue Ban. 2011 Apr 18;43(2):228-33
pubmed: 21503117
Exp Brain Res. 2009 Feb;193(1):109-18
pubmed: 18936923
Pathog Dis. 2016 Aug;74(6):
pubmed: 27405485
J Neurochem. 2004 Mar;88(6):1555-69
pubmed: 15009657
Neuroepidemiology. 2013;41(2):118-30
pubmed: 23860588
Sci China Life Sci. 2019 Oct;62(10):1332-1367
pubmed: 31444682
Amyotroph Lateral Scler Frontotemporal Degener. 2019 Nov;20(7-8):619-624
pubmed: 30945567
Trends Neurosci. 2005 Sep;28(9):494-500
pubmed: 16026864
Antioxidants (Basel). 2020 Jul 03;9(7):
pubmed: 32635299
Int J Mol Med. 2008 Apr;21(4):405-11
pubmed: 18360685
Int Immunopharmacol. 2009 Dec;9(13-14):1549-54
pubmed: 19781666
Immun Ageing. 2010 Jan 17;7(1):1
pubmed: 20205886
Med Chem. 2021;17(9):983-993
pubmed: 32885758
J Biol Chem. 2005 Feb 11;280(6):4532-43
pubmed: 15579468
J Mol Graph Model. 2017 Jun;74:288-295
pubmed: 28458007
Neurochem Res. 2006 Oct;31(10):1263-9
pubmed: 17021948
J Med Food. 2010 Oct;13(5):1081-5
pubmed: 20626250
Cell. 1993 Oct 22;75(2):241-51
pubmed: 7503812
J Appl Toxicol. 2001 Dec;21 Suppl 1:S47-51
pubmed: 11920920
Phytother Res. 2020 May;34(5):1071-1082
pubmed: 31880854
Drug Des Devel Ther. 2021 Feb 04;15:385-397
pubmed: 33574657
Chem Biol Interact. 2008 Jul 10;174(1):51-9
pubmed: 18513711
Oxid Med Cell Longev. 2017;2017:5058609
pubmed: 28785376
Expert Opin Investig Drugs. 2012 Sep;21(9):1267-308
pubmed: 22741814
J Clin Biochem Nutr. 2016 Nov;59(3):155-159
pubmed: 27895381
Int J Mol Sci. 2019 Nov 12;20(22):
pubmed: 31726793
CNS Neurol Disord Drug Targets. 2014 Feb;13(1):82-95
pubmed: 24152330
Neurotherapeutics. 2014 Apr;11(2):419-32
pubmed: 24414863
CNS Neurol Disord Drug Targets. 2018;17(10):767-779
pubmed: 30033879
Antioxidants (Basel). 2019 Sep 18;8(9):
pubmed: 31540440
Zhongguo Zhong Yao Za Zhi. 2001 Jun;26(6):413-6
pubmed: 12528512
Inflammation. 2016 Dec;39(6):1904-1917
pubmed: 27624059
Ann Neurol. 2011 Dec;70(6):913-9
pubmed: 21842496
Nat Rev Neurosci. 2006 Sep;7(9):710-23
pubmed: 16924260
Neurol Sci. 2015 Jul;36(7):1181-8
pubmed: 25596147
Cell Mol Neurobiol. 2008 Feb;28(2):293-305
pubmed: 17647102
Neurochem Res. 2020 Apr;45(4):720-730
pubmed: 32002772
J Neurol Neurosurg Psychiatry. 2010 Apr;81(4):385-90
pubmed: 19710046
Toxicon. 2004 Jan;43(1):53-9
pubmed: 15037029
Curr Pharm Des. 2020;26(7):772-779
pubmed: 31914904
Neurochem Res. 2018 Dec;43(12):2304-2312
pubmed: 30317421
Phytother Res. 2014 Jan;28(1):9-21
pubmed: 23519768
Am J Hypertens. 2010 Aug;23(8):821
pubmed: 20644533
Am J Chin Med. 2007;35(4):681-91
pubmed: 17708634
Oxid Med Cell Longev. 2017;2017:2525967
pubmed: 28785371
Curr Neuropharmacol. 2019;17(3):247-267
pubmed: 30207234
Expert Opin Drug Discov. 2011 Nov;6(11):1127-38
pubmed: 22646982
J Tissue Eng Regen Med. 2019 Jan;13(1):110-115
pubmed: 30479062
EMBO J. 2007 Jul 11;26(13):3169-79
pubmed: 17581637
Oncotarget. 2017 Feb 14;8(7):10777-10778
pubmed: 28099897
Nat Rev Neurol. 2011 Nov;7(11):616-30
pubmed: 22051914
Planta Med. 2007 Jun;73(7):650-4
pubmed: 17583824
Neurochem Int. 2016 May;95:100-8
pubmed: 26550708
Biol Pharm Bull. 2000 Jul;23(7):890-2
pubmed: 10919373
Eur J Med Chem. 2016 Oct 4;121:903-917
pubmed: 27372371
P T. 2018 Jan;43(1):25-28
pubmed: 29290672
OMICS. 2020 Jul;24(7):394-403
pubmed: 32486962
Molecules. 2015 Apr 29;20(5):7775-89
pubmed: 25939067
Curr Drug Targets. 2016;17(12):1331-40
pubmed: 26343107
Life Sci. 2002 Jun 21;71(5):591-9
pubmed: 12052443
Acta Pharmacol Sin. 2007 Dec;28(12):1881-90
pubmed: 18031600
Acta Biochim Pol. 2016;63(3):589-93
pubmed: 27474401
Phytother Res. 2011 May;25(5):681-5
pubmed: 21043034
Curr Drug Discov Technol. 2022;19(1):e140122191102
pubmed: 33538676
Adv Ther. 2020 Jan;37(1):113-139
pubmed: 31782132
Curr Pharm Biotechnol. 2015;16(3):211-8
pubmed: 25601606
Zhong Yao Cai. 2011 Nov;34(11):1750-3
pubmed: 22506403
Acta Neurol Scand. 2010 Sep;122(3):217-23
pubmed: 20078446
Neurosci Lett. 2006 Mar 6;395(2):103-7
pubmed: 16356650
J Agric Food Chem. 2002 May 22;50(11):3337-40
pubmed: 12010007
Shock. 2012 Mar;37(3):312-8
pubmed: 22089194
Curr Med Chem. 2021;28(23):4799-4825
pubmed: 32744957
ACS Omega. 2020 Oct 14;5(42):27480-27491
pubmed: 33134711
Prog Neurobiol. 2016 Jul;142:104-129
pubmed: 27236050
J Invest Surg. 2020 Feb;33(2):182-188
pubmed: 29869899
Lancet Neurol. 2017 Jul;16(7):505-512
pubmed: 28522181
Int Immunopharmacol. 2005 Jan;5(1):185-93
pubmed: 15589480
Pharmacol Rep. 2007 Sep-Oct;59(5):573-9
pubmed: 18048958
Brain Res Bull. 2010 Oct 30;83(5):196-201
pubmed: 20637265
Neurotoxicology. 2019 Mar;71:6-15
pubmed: 30503815
Metab Brain Dis. 2018 Aug;33(4):1031-1043
pubmed: 29681010
Exp Mol Med. 2007 Dec 31;39(6):715-21
pubmed: 18160842
Cytotherapy. 2020 Feb;22(2):106-113
pubmed: 31983606
Folia Neuropathol. 2019;57(2):170-181
pubmed: 31556576
Acta Neurol Scand. 2012 Jul;126(1):62-6
pubmed: 22034926
Curr Top Med Chem. 2001 Dec;1(6):553-68
pubmed: 11895131
Amyotroph Lateral Scler Other Motor Neuron Disord. 2001 Mar;2 Suppl 1:S47-54
pubmed: 11465925
Neurodegener Dis. 2005;2(3-4):147-59
pubmed: 16909020
Int J Mol Sci. 2019 Jun 22;20(12):
pubmed: 31234550
Curr Opin Investig Drugs. 2002 Dec;3(12):1720-4
pubmed: 12528305
Int J Mol Med. 2017 Nov;40(5):1444-1456
pubmed: 28901374
Nat Rev Neurol. 2014 Nov;10(11):661-70
pubmed: 25311585
Sheng Li Xue Bao. 2017 Dec 25;69(6):751-758
pubmed: 29270590
Neurology. 2009 May 12;72(19):1640-5
pubmed: 19433736