Differences in synovial fibrosis relative to range of motion in knee osteoarthritis patients.
arthroplasty knee
clinical outcomes
fibrosis
osteoarthritis
synovium
Journal
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
ISSN: 1554-527X
Titre abrégé: J Orthop Res
Pays: United States
ID NLM: 8404726
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
revised:
12
04
2021
received:
23
10
2020
accepted:
19
04
2021
pubmed:
30
4
2021
medline:
19
4
2022
entrez:
29
4
2021
Statut:
ppublish
Résumé
This study tests if differences exist in the severity of synovial fibrosis between patients undergoing total knee arthroplasty (TKA) for osteoarthritis (OA) to help explain disparate deficits in pre- and postoperative range of motion (ROM) between patient groups. 117 knee OA patients were grouped by women (n = 74) and men (n = 43) or those who self-reported as Black (n = 48) or White (n = 69). ROM was measured pre- and post-TKA. Condyles and synovium collected during TKA were scored histologically for OA severity and synovitis. Fibrosis was measured from picrosirius-stained sections of the synovium. Data were analyzed using Mann-Whitney, parametric, and Spearman's rho tests with alpha at 0.05. We found no significant differences between patient age, BMI, radiographic scores, or deformity type when grouped by sex or race, or between metrics or OA severity when grouped by sex. Notably, higher synovitis was measured in women (p = .039) than men. White patients had greater ROM before (p = 0.46) and after surgery (p = .021) relative to Black patients. Fibrosis, but not OA severity and synovitis scores, for the total patient sample negatively correlated with preoperative (r
Identifiants
pubmed: 33913554
doi: 10.1002/jor.25061
pmc: PMC8553814
mid: NIHMS1696738
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
584-594Subventions
Organisme : NIGMS NIH HHS
ID : U54 GM104940
Pays : United States
Informations de copyright
© 2021 Orthopaedic Research Society. Published by Wiley Periodicals LLC.
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