Short chain fatty acids released by Fusobacterium nucleatum are neutrophil chemoattractants acting via free fatty acid receptor 2 (FFAR2).
FFAR2
GPR43
PMN
SCFA
acetate
granulocyte
periodontitis
propionate
Journal
Cellular microbiology
ISSN: 1462-5822
Titre abrégé: Cell Microbiol
Pays: India
ID NLM: 100883691
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
12
04
2021
received:
26
02
2021
accepted:
26
04
2021
pubmed:
30
4
2021
medline:
14
1
2022
entrez:
29
4
2021
Statut:
ppublish
Résumé
Fusobacterium nucleatum is a gram-negative and anaerobic oral commensal that is implicated in inflammatory conditions of the tooth-supporting structures, that is, periodontal diseases. One of the main characteristics of these conditions is an accumulation of neutrophil granulocytes in the gingival pockets where bacteria reside. Neutrophils are recruited to tissue-residing microbes by gradients of bacteria derived chemoattractants, and the cellular migration over the pocket epithelium into the gingival pocket is likely governed by chemoattractants released by the amino acid fermenting anaerobes typically colonising this site. However, the chemoattractants released by F. nucleatum and other oral anaerobes have long been unidentified. In the present study, we show that the major chemoattractants released during the growth of F. nucleatum are short chain fatty acids (SCFAs), primarily acetate and butyrate. These SCFAs, that are released at high levels as end-products of the metabolism of F. nucleatum, trigger chemotaxis of human neutrophils, as well as cytosolic Ca
Substances chimiques
Chemotactic Factors
0
Fatty Acids, Nonesterified
0
Fatty Acids, Volatile
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13348Subventions
Organisme : King Gustaf V's 80-year foundation
Organisme : Swedish state under TUA-agreement
ID : 917531
Organisme : Vetenskapsrådet
ID : 2019-01123
Informations de copyright
© 2021 The Authors. Cellular Microbiology published by John Wiley & Sons Ltd.
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