Dry eye disease and retinal nerve fiber layer changes in chronic smokers.
Chronic smokers
pack-year
retinal nerve fiber layer thickness
tear film parameters
Journal
Indian journal of ophthalmology
ISSN: 1998-3689
Titre abrégé: Indian J Ophthalmol
Pays: India
ID NLM: 0405376
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
entrez:
29
4
2021
pubmed:
30
4
2021
medline:
28
5
2021
Statut:
ppublish
Résumé
To study the effect of smoking on tear film parameters and retinal nerve fiber layer thickness (RNFL) in chronic smokers. This was a cross-sectional study, which included 60 (120 eyes) smokers who have smoked at least 10 pack-year and an equal number of healthy subjects as a control for comparison. In addition to history, a detailed slit-lamp examination was done to evaluate the anterior and posterior segments. All patients underwent Schirmer's I test (SIT) with Whatman-41 filter paper, tear meniscus height (TMH), and RNFL with a Fourier-domain optical coherence tomography (OCT) and tear film breakup time (TBUT) with 2% fluorescein and cobalt blue filter using slit-lamp biomicroscopy. The (mean ± SD) age of the participants was 56.48 ± 10.38 years. There was a statistically significant reduction in tear film parameters in smokers compared to nonsmokers (P = 0.000). The incidence of MGD was found to be higher in smokers when compared to nonsmokers with a P value of 0.000. RNFL in all four quadrants was also significantly reduced in smokers compared to nonsmokers (P = 0.00). This study shows that chronic smoking leads to an increased incidence of dry eye disease and is associated with RNFL thinning. Smoking can result in cumulative RNFL loss in patients with ocular neurodegenerative disorder and OCT of these patients may have to be interpreted keeping this in mind.
Identifiants
pubmed: 33913855
pii: IndianJOphthalmol_2021_69_5_1178_314799
doi: 10.4103/ijo.IJO_976_20
pmc: PMC8186622
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1178-1182Déclaration de conflit d'intérêts
None
Références
Cytokine. 2008 Aug;43(2):200-8
pubmed: 18602273
Ophthalmology. 1999 Mar;106(3):570-9
pubmed: 10080216
Optom Vis Sci. 2006 Nov;83(11):797-802
pubmed: 17106406
Clin Exp Ophthalmol. 2003 Jun;31(3):229-32
pubmed: 12786773
Acta Ophthalmol Scand. 2003 Dec;81(6):583-7
pubmed: 14641258
Eye (Lond). 2016 Apr;30(4):545-52
pubmed: 26768918
Korean J Ophthalmol. 2005 Mar;19(1):18-22
pubmed: 15929482
Sci Rep. 2016 Jun 14;6:27699
pubmed: 27297822
Eye (Lond). 2002 Sep;16(5):594-600
pubmed: 12194075
PLoS One. 2016 Dec 28;11(12):e0168763
pubmed: 28030610
Ophthalmologica. 2003 Jul-Aug;217(4):273-8
pubmed: 12792133
Curr Eye Res. 1996 Jun;15(6):653-61
pubmed: 8670769
Microvasc Res. 2011 Nov;82(3):351-5
pubmed: 21771603
Cutan Ocul Toxicol. 2015;34(4):282-5
pubmed: 25363066
Am J Ophthalmol. 2006 Jun;141(6):1016-1021
pubmed: 16765668
J Cell Physiol. 2013 Dec;228(12):2253-6
pubmed: 23696296
Surv Ophthalmol. 1998 May-Jun;42(6):535-47
pubmed: 9635902
Ophthalmic Epidemiol. 2017 Feb;24(1):24-28
pubmed: 27960583
Australas Med J. 2012;5(4):221-6
pubmed: 22848314
Br J Ophthalmol. 2011 Apr;95(4):509-13
pubmed: 20657017