Loss of PKD1 and PKD2 share common effects on intracellular Ca
ADPKD
Anoctamin 1
Ca(2+) activated Cl(−) channel
Pkd1
Pkd2
Renal cysts
TMEM16A
Journal
Cell calcium
ISSN: 1532-1991
Titre abrégé: Cell Calcium
Pays: Netherlands
ID NLM: 8006226
Informations de publication
Date de publication:
24 Apr 2021
24 Apr 2021
Historique:
received:
30
11
2020
revised:
17
04
2021
accepted:
18
04
2021
pubmed:
30
4
2021
medline:
30
4
2021
entrez:
29
4
2021
Statut:
aheadofprint
Résumé
In polycystic kidney disease (PKD) multiple bilateral renal cysts gradually enlarge causing a decline in renal function. Transepithelial chloride secretion through cystic fibrosis transmembrane conductance regulator (CFTR) and TMEM16A (anoctamin 1) drive cyst enlargement. We demonstrated recently that a loss of PKD1 increases expression and function of TMEM16A in murine kidneys and in mouse M1 collecting duct cells. The data demonstrated that TMEM16A contributes essentially to cyst growth by upregulating intracellular Ca
Identifiants
pubmed: 33915319
pii: S0143-4160(21)00067-1
doi: 10.1016/j.ceca.2021.102413
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
102413Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.