Smoking and risk of COVID-19 hospitalization.
COVID-19
Hospitalization
SARS-COV2
Smoking
Journal
Respiratory medicine
ISSN: 1532-3064
Titre abrégé: Respir Med
Pays: England
ID NLM: 8908438
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
01
02
2021
revised:
07
04
2021
accepted:
11
04
2021
pubmed:
30
4
2021
medline:
27
5
2021
entrez:
29
4
2021
Statut:
ppublish
Résumé
The association between smoking status and severe Coronavirus Disease 2019 (COVID-19) remains controversial. To assess the risk of hospitalization (as a marker of severe COVID-19) in patients by smoking status: former, current and never smokers, who tested positive for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV2) at an academic medical center in the United States. We conducted a retrospective cohort study in patients with SARS-COV2 between March-1-2020 and January-31-2021 to identify the risk of hospitalization due to COVID-19 by smoking status. We identified 10216 SARS-COV2-positive patients with complete documentation of smoking habits. Within 14 days of a SARS-COV2 positive test, 1150 (11.2%) patients were admitted and 188 (1.8%) died. Significantly more former smokers were hospitalized from COVID-19 than current or never smokers (21.2% former smokers; 7.3% current smokers; 10.4% never smokers, p<0.0001). In univariable analysis, former smokers had higher odds of hospitalization from COVID-19 than never smokers (OR 2.31; 95% CI 1.94-2.74). This association remained significant when analysis was adjusted for age, race and gender (OR 1.28; 95% CI 1.06-1.55), but became non-significant when analysis included Body Mass Index, previous hospitalization and number of comorbidities (OR 1.05; 95% CI 0.86-1.29). In contrast, current smokers were less likely than never smokers to be hospitalized due to COVID-19. Significantly more former smokers were hospitalized and died from COVID-19 than current or never smokers. This effect is mediated via age and comorbidities in former smokers.
Identifiants
pubmed: 33915414
pii: S0954-6111(21)00120-7
doi: 10.1016/j.rmed.2021.106414
pmc: PMC8052507
pii:
doi:
Substances chimiques
RNA, Viral
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
106414Subventions
Organisme : AHRQ HHS
ID : R01 HS020642
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Références
J Virol. 2005 Feb;79(3):1966-9
pubmed: 15650225
Oncotarget. 2017 Jan 3;8(1):268-284
pubmed: 27902485
N Engl J Med. 2020 Jun 18;382(25):2441-2448
pubmed: 32356628
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
Am J Respir Crit Care Med. 2020 Jun 1;201(11):1380-1388
pubmed: 32275452
Chest. 1999 Aug;116(2):375-9
pubmed: 10453865
Arch Intern Med. 2004 Nov 8;164(20):2206-16
pubmed: 15534156
Ann Am Thorac Soc. 2021 Aug;18(8):1326-1334
pubmed: 33724166
Eur Respir J. 2020 Jun 4;55(6):
pubmed: 32366490
Chest. 2013 Jan;143(1):196-206
pubmed: 23276842
Inflammation. 2011 Aug;34(4):231-7
pubmed: 20625922
Nature. 2020 Aug;584(7821):425-429
pubmed: 32604404
Am J Public Health. 1993 Sep;83(9):1277-83
pubmed: 8363004
BMJ Evid Based Med. 2021 Dec;26(6):279-284
pubmed: 32788164
JAMA. 2020 May 26;323(20):2052-2059
pubmed: 32320003
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
N Engl J Med. 1982 Oct 21;307(17):1042-6
pubmed: 7121513
Arch Acad Emerg Med. 2020 Mar 24;8(1):e35
pubmed: 32232218
Am J Public Health. 1994 Nov;84(11):1750-6
pubmed: 7977912
Lancet Infect Dis. 2020 Jun;20(6):669-677
pubmed: 32240634
Science. 2020 Jul 10;369(6500):208-211
pubmed: 32404476
Lancet. 2003 Aug 16;362(9383):507-15
pubmed: 12932381
Intern Emerg Med. 2020 Aug;15(5):853-856
pubmed: 32430652
Tuber Lung Dis. 1996 Dec;77(6):570
pubmed: 9039455
Am J Respir Crit Care Med. 2020 Jun 15;201(12):1557-1559
pubmed: 32329629
Am J Physiol Regul Integr Comp Physiol. 2018 Nov 1;315(5):R895-R906
pubmed: 30088946
Thorax. 2021 Jul;76(7):714-722
pubmed: 33402392
N Engl J Med. 2000 Mar 9;342(10):681-9
pubmed: 10706897
J Adolesc Health. 2020 Sep;67(3):362-368
pubmed: 32674964
Lancet. 2013 Jan 12;381(9861):133-41
pubmed: 23107252
Am J Public Health. 1981 May;71(5):530-2
pubmed: 7212144
Eur Respir J. 2020 May 14;55(5):
pubmed: 32269089
J Med Virol. 2020 Oct;92(10):1915-1921
pubmed: 32293753
Int J Obes (Lond). 2020 Sep;44(9):1807-1809
pubmed: 32647359
Intern Emerg Med. 2020 Aug;15(5):845-852
pubmed: 32385628
Allergy. 2020 Jul;75(7):1730-1741
pubmed: 32077115
Am J Respir Crit Care Med. 2020 Aug 1;202(3):471-472
pubmed: 32530714
Am J Health Promot. 2000 Jul-Aug;14(6):357-61
pubmed: 11067570
Am J Respir Crit Care Med. 2020 Sep 15;202(6):812-821
pubmed: 32584597
Chest. 2018 Feb;153(2):575-578
pubmed: 29406227
Tubercle. 1988 Jun;69(2):105-12
pubmed: 3188230
Eur J Intern Med. 2020 May;75:107-108
pubmed: 32192856
Am J Epidemiol. 1969 Nov;90(5):390-9
pubmed: 5356947