Three-dimensional surface strain analyses of simulated defect and augmented spine segments: A biomechanical cadaveric study.
Biomechanics of vertebral bodies
Fracture outcomes
Mechanical testing
Metastasis
Vertebral augmentation
Journal
Journal of the mechanical behavior of biomedical materials
ISSN: 1878-0180
Titre abrégé: J Mech Behav Biomed Mater
Pays: Netherlands
ID NLM: 101322406
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
09
11
2020
revised:
09
04
2021
accepted:
19
04
2021
pubmed:
30
4
2021
medline:
22
5
2021
entrez:
29
4
2021
Statut:
ppublish
Résumé
While several studies have investigated fracture outcomes of intact vertebrae, fracture properties in metastatically-involved and augmented vertebrae are still far from understood. Consequently, this study was aimed to use 3D digital image correlation (3D-DIC) method to investigate the failure properties of spine segments with simulated metastatic lesions, segments augmented with poly(propylene fumarate) (PPF), and compare the outcomes with intact spines. To this end, biomechanical experiments accompanied by 3D-DIC were performed on spine segments consisting of three vertebrae and two intervertebral discs (IVDs) at loading rates of 0.083 mm/s, mimicking a physiological loading condition, and 200 mm/s, mimicking an impact-type loading condition such as a fall or an accident. Full-field surface strain analysis indicated PPF augmentation reduces the superior/inferior strain when compared with the defect specimens; Presence of a defect in the middle vertebra resulted in shear band fracture pattern. Failure of the superior endplates was confirmed in several defect specimens as the superior IVDs were protruding out of defects. The augmenting PPF showed lower superior/inferior surface strain values at the fast speed as compared to the slow speed. The results of our study showed a significant increase in the fracture force from slow to fast speeds (p = 0.0246). The significance of the study was to determine the fracture properties of normal, pathological, and augmented spinal segments under physiologically-relevant loading conditions. Understanding failure properties associated with either defect (i.e., metastasis lesion) or augmented (i.e., post-treatment) spine segments could potentially provide new insights on the outcome prediction and treatment planning. Additionally, this study provides new knowledge on the effect of PPF augmentation in improving fracture properties, potentially decreasing the risk of fracture in osteoporotic and metastatic spines.
Identifiants
pubmed: 33915439
pii: S1751-6161(21)00241-1
doi: 10.1016/j.jmbbm.2021.104559
pmc: PMC8744146
mid: NIHMS1765969
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104559Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR056212
Pays : United States
Organisme : NIAMS NIH HHS
ID : T32 AR056950
Pays : United States
Informations de copyright
Copyright © 2021. Published by Elsevier Ltd.
Références
J Biomech. 2020 Jun 9;106:109826
pubmed: 32517988
J Biomech Eng. 2018 Oct 1;140(10):
pubmed: 30029248
Ann Biomed Eng. 2000 Sep;28(9):1154-8
pubmed: 11132199
J Mech Behav Biomed Mater. 2019 Dec;100:103399
pubmed: 31479817
J Spine Surg. 2016 Jun;2(2):111-21
pubmed: 27683707
Pain Physician. 2011 Jul-Aug;14(4):E373-403
pubmed: 21785487
J Biomech. 2004 May;37(5):653-60
pubmed: 15046994
Spine (Phila Pa 1976). 2017 Nov 15;42(22):E1289-E1296
pubmed: 28306642
J Biomech Eng. 2016 May;138(5):054501
pubmed: 26902321
J Spinal Cord Med. 2020 Jan;43(1):39-45
pubmed: 29446706
AJR Am J Roentgenol. 1992 Jun;158(6):1275-9
pubmed: 1590123
J Mech Behav Biomed Mater. 2015 Jan;41:271-9
pubmed: 25154535
Open Access Rheumatol. 2019 Jul 03;11:157-161
pubmed: 31308767
J Biomech Eng. 2010 Aug;132(8):081012
pubmed: 20670061
Spine J. 2015 Aug 1;15(8):1856-63
pubmed: 25862512
Biomacromolecules. 2006 Jun;7(6):1976-82
pubmed: 16768422
Biomaterials. 2002 Nov;23(22):4381-7
pubmed: 12219828
Eur Spine J. 2013 Oct;22(10):2184-201
pubmed: 23508335
Acta Biomater. 2015 May;18:9-20
pubmed: 25575855
Spine (Phila Pa 1976). 2008 Jul 1;33(15):1627-36
pubmed: 18594454
J Mech Behav Biomed Mater. 2016 Jan;53:119-130
pubmed: 26318572
Tissue Eng Part A. 2014 Mar;20(5-6):1096-102
pubmed: 24256208
Spine (Phila Pa 1976). 2006 Oct 15;31(22):2562-8
pubmed: 17047545
Neurochirurgie. 1987;33(2):166-8
pubmed: 3600949
Clin Biomech (Bristol, Avon). 1997 Jul;12(5):301-305
pubmed: 11415738
J Prosthet Dent. 1991 Sep;66(3):292-8
pubmed: 1800722
J Mech Behav Biomed Mater. 2017 Jan;65:801-807
pubmed: 27776322
J Biomater Sci Polym Ed. 2001;12(6):673-87
pubmed: 11556743
Eur Spine J. 2003 Aug;12(4):421-6
pubmed: 12687437
Biomaterials. 1996 Nov;17(22):2127-30
pubmed: 9035745