High Dietary Phosphate Exacerbates and Acts Independently of Low Autophagy Activity in Pathological Cardiac Remodeling and Dysfunction.

Animals Autophagy / drug effects Autophagy-Related Protein 5 / metabolism Cardiomegaly / pathology Diet Fibrosis Heart / drug effects Kidney / pathology Longevity Mice, Transgenic Models, Biological Myocytes, Cardiac / metabolism Phosphates / adverse effects Ventricular Remodeling / drug effects
apoptosis atg5 autophagy cardiomyocyte cardiomyopathy phosphotoxicity

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
01 04 2021
Historique:
received: 09 03 2021
revised: 26 03 2021
accepted: 29 03 2021
entrez: 30 4 2021
pubmed: 1 5 2021
medline: 25 2 2023
Statut: epublish

Résumé

High phosphate contributes to uremic cardiomyopathy. Abnormal autophagy is associated with the development and progression of heart disease. What is unknown is the effects of phosphate on autophagy and whether the ill effects of phosphate on cardiomyocytes are mediated by low autophagy. High (2.0%

Identifiants

DOI: 10.3390/cells10040777 PMID: 33915953 PMC: PMC8065663
pubmed: 33915953
pii: cells10040777
doi: 10.3390/cells10040777
pmc: PMC8065663
pii:
doi:

Substances chimiques

Autophagy-Related Protein 5 0
Phosphates 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK091392
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK092461
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30-DK-07938
Pays : United States
Organisme : the Open Foundation of Yichang Key Laboratory of ischemic cardiovascular and cerebrovascular disease translational medicine at China, Three Gorges University
ID : 2017KXN07
Organisme : ndowed Professors' Collaborative Research Support from the Charles Y.C Pak Foundation
ID : 2018, 2019, 2020

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Auteurs

Mingjun Shi (M)

Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Sierra Shepard (S)

Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Zhiyong Zhou (Z)

Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
ORCID: 0000-0002-2835-7947

Jenny Maique (J)

Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Olivia Seli (O)

Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Orson W Moe (OW)

Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Ming Chang Hu (MC)

Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
ORCID: 0000-0002-3235-8301

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › High Dietary Phosphate Exacerbates and Acts...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › High Dietary Phosphate Exacerbates and Acts...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines associées à l'autophagie › Protéine-5 associée à l'autophagie › High Dietary Phosphate Exacerbates and Acts...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Hypertrophie › Cardiomégalie › High Dietary Phosphate Exacerbates and Acts...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › High Dietary Phosphate Exacerbates and Acts...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › High Dietary Phosphate Exacerbates and Acts...
questionsmedicales.fr › Système cardiovasculaire › Coeur › High Dietary Phosphate Exacerbates and Acts...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › High Dietary Phosphate Exacerbates and Acts...
questionsmedicales.fr › Phénomènes physiologiques › Longévité › High Dietary Phosphate Exacerbates and Acts...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › High Dietary Phosphate Exacerbates and Acts...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › High Dietary Phosphate Exacerbates and Acts...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › High Dietary Phosphate Exacerbates and Acts...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du phosphore › Acides du phosphore › Acides phosphoriques › Phosphates › High Dietary Phosphate Exacerbates and Acts...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Fonction ventriculaire › Remodelage ventriculaire › High Dietary Phosphate Exacerbates and Acts...