Prognostic Significance of Glucocorticoid Receptor Expression in Cancer: A Systematic Review and Meta-Analysis.
biomarker
cancer
glucocorticoid receptor
prognosis
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
01 Apr 2021
01 Apr 2021
Historique:
received:
08
02
2021
revised:
17
03
2021
accepted:
24
03
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
In solid malignancies, the glucocorticoid receptor (GR) signalling axis is associated with tumour progression and GR antagonists are in clinical development. Therefore, GR expression may be a useful potential prognostic or predictive biomarker for GR antagonist therapy in cancer. The aim of this review is to investigate if GR expression in tumours is predictive of overall survival or progression free survival. Twenty-five studies were identified through systematic searches of three databases and a meta-analysis conducted using a random effects model, quantifying statistical heterogeneity. Subgroup analysis was conducted for cancer types and publication bias was assessed via funnel plots. There was high heterogeneity in meta-analysis of the studies in all cancer types, which found no association between high GR expression with overall survival (pooled unadjusted HR 1.16, 95% CI (0.89-1.50),
Identifiants
pubmed: 33916028
pii: cancers13071649
doi: 10.3390/cancers13071649
pmc: PMC8037088
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
BMC Cancer. 2020 Feb 27;20(1):161
pubmed: 32106831
Sci Rep. 2019 Nov 14;9(1):16794
pubmed: 31727962
Clin Cancer Res. 2018 Jul 15;24(14):3433-3446
pubmed: 29636357
Breast Cancer Res Treat. 2015 Apr;150(2):335-46
pubmed: 25762479
Cancer Biol Ther. 2016 Nov;17(11):1188-1196
pubmed: 27635763
Gynecol Oncol. 2000 Jun;77(3):429-32
pubmed: 10831354
BMC Cancer. 2011 May 27;11:207
pubmed: 21619605
J Steroid Biochem Mol Biol. 2005 Apr;94(5):383-94
pubmed: 15876404
Clin Cancer Res. 2013 Nov 15;19(22):6163-72
pubmed: 24016618
BJU Int. 2008 May;101(9):1084-9
pubmed: 18399827
Oncologist. 2015 Mar;20(3):247-56
pubmed: 25657202
Cancer. 2011 Oct 1;117(19):4396-405
pubmed: 21437890
Pharmacol Ther. 2020 Nov;215:107623
pubmed: 32622856
Hum Pathol. 2011 Nov;42(11):1684-92
pubmed: 21531004
Am J Clin Pathol. 2014 Aug;142(2):157-64
pubmed: 25015855
Cancer Res. 2011 Oct 15;71(20):6360-70
pubmed: 21868756
Cell. 1990 Sep 21;62(6):1217-26
pubmed: 2169353
Surgery. 2002 Jan;131(1):19-25
pubmed: 11812959
Cancer Manag Res. 2017 Mar 06;9:65-72
pubmed: 28293120
Lung Cancer. 2006 Sep;53(3):303-10
pubmed: 16806572
Eur J Cancer. 2006 Dec;42(18):3287-93
pubmed: 17070682
Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):752-6
pubmed: 8290595
Eur J Cancer. 2020 Dec;141:105-114
pubmed: 33130548
Contraception. 2003 Dec;68(6):409-20
pubmed: 14698070
J Clin Bioinforma. 2011 Feb 28;1(8):1-11
pubmed: 21603121
Blood. 1993 Oct 15;82(8):2304-9
pubmed: 8400283
Prostate. 1995 Apr;26(4):194-204
pubmed: 7716084
Gynecol Oncol. 2017 Dec;147(3):672-677
pubmed: 28927900
Mol Cell Endocrinol. 2018 May 5;466:38-50
pubmed: 28687451
Br J Cancer. 2018 May;118(9):1208-1216
pubmed: 29563635
Sci Transl Med. 2015 Sep 16;7(305):305ps19
pubmed: 26378243
Arch Gynecol Obstet. 2019 Jan;299(1):203-209
pubmed: 30306311
Nat Commun. 2017 Jan 19;8:14073
pubmed: 28102225
Eur J Endocrinol. 2007 Nov;157(5):561-9
pubmed: 17984235
Mol Cancer Ther. 2012 Dec;11(12):2621-32
pubmed: 23033490
Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5479-84
pubmed: 25847991
Gynecol Oncol. 2017 Jul;146(1):153-160
pubmed: 28456378
Mol Cancer Res. 2016 Aug;14(8):707-19
pubmed: 27141101
Histopathology. 2008 Feb;52(3):314-24
pubmed: 18269582
Cancer Treat Rep. 1979 Aug;63(8):1271-7
pubmed: 476705
Clin Cancer Res. 2005 Sep 1;11(17):6325-32
pubmed: 16144937
Apoptosis. 2006 Jul;11(7):1247-55
pubmed: 16699951
Cancer Res. 2004 Mar 1;64(5):1757-64
pubmed: 14996737
J Gastrointest Surg. 2006 May;10(5):706-11
pubmed: 16713543
Int J Gynecol Cancer. 2019 Feb;29(2):357-364
pubmed: 30683758
Cell Rep. 2018 Mar 13;22(11):2995-3005
pubmed: 29539426
Oncol Rep. 2006 May;15(5):1137-40
pubmed: 16596175
Ann N Y Acad Sci. 1995 Jun 12;761:296-310
pubmed: 7625728
Clin Cancer Res. 2020 Mar 1;26(5):1175-1184
pubmed: 31772120
J Oncol. 2020 May 20;2020:3712825
pubmed: 32565802
Nat Commun. 2015 Sep 16;6:8323
pubmed: 26374485
Pathol Int. 2020 Jun;70(6):355-363
pubmed: 32173971
Clin Cancer Res. 2018 Feb 15;24(4):927-938
pubmed: 29158269
Steroids. 2016 Jul;111:84-88
pubmed: 26930575
Ann Intern Med. 2013 Feb 19;158(4):280-6
pubmed: 23420236
Breast Cancer Res Treat. 2020 Feb;180(1):97-110
pubmed: 31989378
Adv Exp Med Biol. 2015;872:315-33
pubmed: 26216001
Cancer Biol Ther. 2006 Jan;5(1):59-64
pubmed: 16294015
J Cancer. 2020 Jan 1;11(3):696-701
pubmed: 31942193
J Mol Cell Biol. 2019 Dec 19;11(12):1042-1055
pubmed: 30726932
Dig Dis Sci. 2003 Sep;48(9):1745-50
pubmed: 14560994
Am Soc Clin Oncol Educ Book. 2020 Mar;40:1-11
pubmed: 32239967
Stat Med. 1998 Dec 30;17(24):2815-34
pubmed: 9921604
Nature. 2019 Mar;567(7749):540-544
pubmed: 30867597
Clin Cancer Res. 2012 Oct 1;18(19):5499-506
pubmed: 22855579
Cell Death Dis. 2020 Sep 23;11(9):790
pubmed: 32989221