Enhanced Intestinal TGF-β/SMAD-Dependent Signaling in Simian Immunodeficiency Virus Infected Rhesus Macaques.


Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
04 04 2021
Historique:
received: 29 01 2021
revised: 18 03 2021
accepted: 01 04 2021
entrez: 30 4 2021
pubmed: 1 5 2021
medline: 21 10 2021
Statut: epublish

Résumé

Transforming growth factor-β signaling (TGF-β) maintains a balanced physiological function including cell growth, differentiation, and proliferation and regulation of immune system by modulating either SMAD2/3 and SMAD7 (SMAD-dependent) or SMAD-independent signaling pathways under normal conditions. Increased production of TGF-β promotes immunosuppression in Human Immunodeficiency Virus (HIV)/Simian Immunodeficiency Virus (SIV) infection. However, the cellular source and downstream events of increased TGF-β production that attributes to its pathological manifestations remain unknown. Here, we have shown increased production of TGF-β in a majority of intestinal CD3

Identifiants

pubmed: 33916615
pii: cells10040806
doi: 10.3390/cells10040806
pmc: PMC8066988
pii:
doi:

Substances chimiques

Smad Proteins 0
Transforming Growth Factor beta 0
Receptor, Transforming Growth Factor-beta Type II EC 2.7.11.30

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIH HHS
ID : P51 OD011104
Pays : United States
Organisme : NCRR NIH HHS
ID : P51 RR000164
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK109883
Pays : United States

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Auteurs

Nongthombam Boby (N)

Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA.

Alyssa Ransom (A)

Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA.

Barcley T Pace (BT)

Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA.

Kelsey M Williams (KM)

Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA.

Christopher Mabee (C)

Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA.

Arpita Das (A)

Division of Microbiology, Tulane National Primate Research Center, Covington, LA 70433, USA.

Sudesh K Srivastav (SK)

Department of Biostatistics, Tulane University, New Orleans, LA 70112, USA.

Edith Porter (E)

Department of Biological Sciences, California State University Los Angeles, Los Angeles, CA 90032, USA.

Bapi Pahar (B)

Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA.
Tulane University School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Tulane School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA.

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Classifications MeSH