Enhanced Intestinal TGF-β/SMAD-Dependent Signaling in Simian Immunodeficiency Virus Infected Rhesus Macaques.
Animals
Disease Progression
Down-Regulation
Feedback, Physiological
Gene Expression Regulation
Intestines
/ pathology
Macaca mulatta
Models, Biological
Phosphorylation
Receptor, Transforming Growth Factor-beta Type II
/ metabolism
Signal Transduction
Simian Acquired Immunodeficiency Syndrome
/ blood
Simian Immunodeficiency Virus
/ physiology
Smad Proteins
/ metabolism
Transforming Growth Factor beta
/ metabolism
Up-Regulation
Viral Load
CD4
CD68
SMAD signaling pathway
SMAD3
SMAD7
TGF-β receptor
TGF-β1
rhesus macaque
simian immunodeficiency virus
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
04 04 2021
04 04 2021
Historique:
received:
29
01
2021
revised:
18
03
2021
accepted:
01
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
21
10
2021
Statut:
epublish
Résumé
Transforming growth factor-β signaling (TGF-β) maintains a balanced physiological function including cell growth, differentiation, and proliferation and regulation of immune system by modulating either SMAD2/3 and SMAD7 (SMAD-dependent) or SMAD-independent signaling pathways under normal conditions. Increased production of TGF-β promotes immunosuppression in Human Immunodeficiency Virus (HIV)/Simian Immunodeficiency Virus (SIV) infection. However, the cellular source and downstream events of increased TGF-β production that attributes to its pathological manifestations remain unknown. Here, we have shown increased production of TGF-β in a majority of intestinal CD3
Identifiants
pubmed: 33916615
pii: cells10040806
doi: 10.3390/cells10040806
pmc: PMC8066988
pii:
doi:
Substances chimiques
Smad Proteins
0
Transforming Growth Factor beta
0
Receptor, Transforming Growth Factor-beta Type II
EC 2.7.11.30
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : P51 OD011104
Pays : United States
Organisme : NCRR NIH HHS
ID : P51 RR000164
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK109883
Pays : United States
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