Targeting the Fibroblast Growth Factor Receptor (FGFR) in Advanced Cholangiocarcinoma: Clinical Trial Progress and Future Considerations.
TAS-120
cholangiocarcinoma
debio 1347
derazantinib
erdafitinib
fibroblast growth factor receptor (FGFR)
futibatinib
infigratinib
pemigatinib
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
03 Apr 2021
03 Apr 2021
Historique:
received:
22
02
2021
revised:
15
03
2021
accepted:
31
03
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
Landmark molecular profiling efforts have identified multiple targetable alterations in cholangiocarcinoma. Among the molecular-driven subsets of cholangiocarcinoma, targeting the fibroblast growth factor receptor (FGFR) has shown promise and represents the first targeted therapy to be approved in treatment-refractory, advanced cholangiocarcinoma. In this review, we provide an up-to-date overview of the clinical development of FGFR inhibitors in advanced cholangiocarcinoma. We review the FGFR pathway and discuss emerging issues including resistance to FGFR inhibitors. We end with a discussion on future considerations to optimize the potential of this class of therapeutics in advanced cholangiocarcinoma.
Identifiants
pubmed: 33916849
pii: cancers13071706
doi: 10.3390/cancers13071706
pmc: PMC8038487
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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