Gingival Crevicular Placental Alkaline Phosphatase Is an Early Pregnancy Biomarker for Pre-Eclampsia.
cohort study
gestation
placental biomarkers
pre-eclampsia
risk prediction model
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
07 Apr 2021
07 Apr 2021
Historique:
received:
19
01
2021
revised:
15
02
2021
accepted:
22
03
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
Early and innovative diagnostic strategies are required to predict the risk of developing pre-eclampsia (PE). The purpose of this study was to evaluate the performance of gingival crevicular fluid (GCF) placental alkaline phosphatase (PLAP) concentrations to correctly classify women at risk of PE. A prospectively collected, retrospectively stratified cohort study was conducted, with 412 pregnant women recruited at 11-14 weeks of gestation. Physical, obstetrical, and periodontal data were recorded. GCF and blood samples were collected for PLAP determination by ELISA assay. A multiple logistic regression classification model was developed, and the classification efficiency of the model was established. Within the study cohort, 4.3% of pregnancies developed PE. GCF-PLAP concentration was 3- to 6-fold higher than in plasma samples. GCF-PLAP concentrations and systolic blood pressure were greater in women who developed PE (
Identifiants
pubmed: 33916883
pii: diagnostics11040661
doi: 10.3390/diagnostics11040661
pmc: PMC8067553
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Fondo de Fomento al Desarrollo Científico y Tecnológico
ID : ID16I10452
Organisme : NICHD NIH HHS
ID : HHSN275201300006C
Pays : United States
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