Left Ventricular Remodeling in Hypertrophic Cardiomyopathy: An Overview of Current Knowledge.
end stage
hypertrophic cardiomyopathy
left ventricular remodeling
risk stratification
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
07 Apr 2021
07 Apr 2021
Historique:
received:
07
03
2021
revised:
02
04
2021
accepted:
05
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
While most patients with hypertrophic cardiomyopathy (HCM) show a relatively stable morphologic and clinical phenotype, in some others, progressive changes in the left ventricular (LV) wall thickness, cavity size, and function, defined, overall, as "LV remodeling", may occur. The interplay of multiple pathophysiologic mechanisms, from genetic background to myocardial ischemia and fibrosis, is implicated in this process. Different patterns of LV remodeling have been recognized and are associated with a specific impact on the clinical course and management of the disease. These findings underline the need for and the importance of serial multimodal clinical and instrumental evaluations to identify and further characterize the LV remodeling phenomenon. A more complete definition of the stages of the disease may present a chance to improve the management of HCM patients.
Identifiants
pubmed: 33916967
pii: jcm10081547
doi: 10.3390/jcm10081547
pmc: PMC8067545
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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