Challenges on Cyclic Nucleotide Phosphodiesterases Imaging with Positron Emission Tomography: Novel Radioligands and (Pre-)Clinical Insights since 2016.
PDE inhibitors
PDE radioligands
cyclic nucleotide phosphodiesterases
imaging
positron emission tomography
radiochemistry
recent (pre-)clinical insights
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
07 Apr 2021
07 Apr 2021
Historique:
received:
26
02
2021
revised:
29
03
2021
accepted:
31
03
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
21
5
2021
Statut:
epublish
Résumé
Cyclic nucleotide phosphodiesterases (PDEs) represent one of the key targets in the research field of intracellular signaling related to the second messenger molecules cyclic adenosine monophosphate (cAMP) and/or cyclic guanosine monophosphate (cGMP). Hence, non-invasive imaging of this enzyme class by positron emission tomography (PET) using appropriate isoform-selective PDE radioligands is gaining importance. This methodology enables the in vivo diagnosis and staging of numerous diseases associated with altered PDE density or activity in the periphery and the central nervous system as well as the translational evaluation of novel PDE inhibitors as therapeutics. In this follow-up review, we summarize the efforts in the development of novel PDE radioligands and highlight (pre-)clinical insights from PET studies using already known PDE radioligands since 2016.
Identifiants
pubmed: 33917199
pii: ijms22083832
doi: 10.3390/ijms22083832
pmc: PMC8068090
pii:
doi:
Substances chimiques
Ligands
0
Radiopharmaceuticals
0
3',5'-Cyclic-AMP Phosphodiesterases
EC 3.1.4.17
3',5'-Cyclic-GMP Phosphodiesterases
EC 3.1.4.35
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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