Small Molecules in the Treatment of Squamous Cell Carcinomas: Focus on Indirubins.
indirubins
small molecules
squamous cell carcinoma
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
07 Apr 2021
07 Apr 2021
Historique:
received:
10
03
2021
revised:
23
03
2021
accepted:
28
03
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
Skin cancers are the most common malignancies in the world. Among the most frequent skin cancer entities, squamous cell carcinoma (SCC) ranks second (~20%) after basal cell carcinoma (~77%). In early stages, a complete surgical removal of the affected tissue is carried out as standard therapy. To treat advanced and metastatic cancers, targeted therapies with small molecule inhibitors are gaining increasing attention. Small molecules are a heterogeneous group of protein regulators, which are produced by chemical synthesis or fermentation. The majority of them belong to the group of receptor tyrosine kinase inhibitors (RTKIs), which specifically bind to certain RTKs and directly influence the respective signaling pathway. Knowledge of characteristic molecular alterations in certain cancer entities, such as SCC, can help identify tumor-specific substances for targeted therapies. Most frequently, altered genes in SCC include
Identifiants
pubmed: 33917267
pii: cancers13081770
doi: 10.3390/cancers13081770
pmc: PMC8068014
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : European Social Fund
ID : ESF/14-BM-A55-0001/18
Organisme : European Social Fund
ID : ESF/14-BM-A55-0002/18
Organisme : European Social Fund
ID : ESF/14-BM-A55-0004/18
Organisme : European Social Fund
ID : ESF/14-BM-A55-0006/18
Organisme : Damp Stiftung
ID : 2017-05
Organisme : Deutsche Forschungsgemeinschaft
ID : EM 68/13-1
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