Anti-Classical Swine Fever Virus Strategies.
RNA interference
antiviral drug
antiviral target
classical swine fever virus
host protein
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
06 Apr 2021
06 Apr 2021
Historique:
received:
02
03
2021
revised:
24
03
2021
accepted:
02
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
Classical swine fever (CSF), caused by CSF virus (CSFV), is a highly contagious swine disease with high morbidity and mortality, which has caused significant economic losses to the pig industry worldwide. Biosecurity measures and vaccination are the main methods for prevention and control of CSF since no specific drug is available for the effective treatment of CSF. Although a series of biosecurity and vaccination strategies have been developed to curb the outbreak events, it is still difficult to eliminate CSF in CSF-endemic and re-emerging areas. Thus, in addition to implementing enhanced biosecurity measures and exploring more effective CSF vaccines, other strategies are also needed for effectively controlling CSF. Currently, more and more research about anti-CSFV strategies was carried out by scientists, because of the great prospects and value of anti-CSFV strategies in the prevention and control of CSF. Additionally, studies on anti-CSFV strategies could be used as a reference for other viruses in the Flaviviridae family, such as hepatitis C virus, dengue virus, and Zika virus. In this review, we aim to summarize the research on anti-CSFV strategies. In detail, host proteins affecting CSFV replication, drug candidates with anti-CSFV effects, and RNA interference (RNAi) targeting CSFV viral genes were mentioned and the possible mechanisms related to anti-CSFV effects were also summarized.
Identifiants
pubmed: 33917361
pii: microorganisms9040761
doi: 10.3390/microorganisms9040761
pmc: PMC8067343
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Science and Technology Program of Guangzhou, China
ID : 201803020005
Organisme : the Science and Technology Program of Guangdong, China
ID : 2019B020211003
Organisme : Guangdong Major Project of Basic and Applied Basic Research
ID : 2020B0301030007
Organisme : the Key Research Projects of Universities in Guangdong Province
ID : 2019KZDXM026
Organisme : 111 Project
ID : D20008
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