Rational Vaccine Design in Times of Emerging Diseases: The Critical Choices of Immunological Correlates of Protection, Vaccine Antigen and Immunomodulation.
adjuvant
antigen
delivery system
design
immunization
rational
route
vaccine
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
06 Apr 2021
06 Apr 2021
Historique:
received:
16
01
2021
revised:
05
03
2021
accepted:
08
03
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
Vaccines are the most effective medical intervention due to their continual success in preventing infections and improving mortality worldwide. Early vaccines were developed empirically however, rational design of vaccines can allow us to optimise their efficacy, by tailoring the immune response. Establishing the immune correlates of protection greatly informs the rational design of vaccines. This facilitates the selection of the best vaccine antigens and the most appropriate vaccine adjuvant to generate optimal memory immune T cell and B cell responses. This review outlines the range of vaccine types that are currently authorised and those under development. We outline the optimal immunological correlates of protection that can be targeted. Finally we review approaches to rational antigen selection and rational vaccine adjuvant design. Harnessing current knowledge on protective immune responses in combination with critical vaccine components is imperative to the prevention of future life-threatening diseases.
Identifiants
pubmed: 33917629
pii: pharmaceutics13040501
doi: 10.3390/pharmaceutics13040501
pmc: PMC8067490
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Austrian Science Fund FWF
ID : P 28915
Pays : Austria
Organisme : Austrian Science Fund FWF
ID : P 32397
Pays : Austria
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