Hippocampal Atrophy in Pediatric Transplant Recipients with Human Herpesvirus 6B.
children
hematopoietic stem cell transplant
hippocampus
human herpesvirus 6B
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
08 Apr 2021
08 Apr 2021
Historique:
received:
06
03
2021
revised:
06
04
2021
accepted:
06
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
The aim of this study was to determine whether human herpesvirus 6B (HHV-6B) infection can impair the hippocampus in pediatric hematopoietic stem cell transplant (HSCT) recipients. Study subjects were pediatric HSCT recipients monitored for HHV-6B infection who underwent brain MRI before and after transplantation. Volumetric analysis of the hippocampus was performed. Of the 107 patients that received HSCT at Nagoya University Hospital Between July 2008 and April 2014, 20 were eligible for volumetric analysis. Eight patients had HHV-6B infection, of whom two had encephalopathy at the time of HHV-6B infection. None of the 12 patients without HHV-6B infection had encephalopathy. The median ratio of the right hippocampal volume from before to after transplantation was 0.93 in patients with HHV-6B infection and 1.02 in without HHV-6B infection (
Identifiants
pubmed: 33917715
pii: microorganisms9040776
doi: 10.3390/microorganisms9040776
pmc: PMC8068176
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 19K17346
Organisme : Mother and Child Health Foundation
ID : 30-10
Références
Arch Dis Child. 2000 Jan;82(1):62-6
pubmed: 10630916
Biol Blood Marrow Transplant. 2012 Nov;18(11):1700-8
pubmed: 22641196
J Pediatr. 1998 Sep;133(3):386-9
pubmed: 9738722
J Med Virol. 2001 Jan;63(1):45-51
pubmed: 11130886
J Neurol Neurosurg Psychiatry. 1995 May;58(5):590-7
pubmed: 7745409
Bone Marrow Transplant. 2012 Oct;47(10):1381-2
pubmed: 22388278
Blood. 1991 Sep 1;78(5):1381-4
pubmed: 1652312
N Engl J Med. 1994 Aug 18;331(7):432-8
pubmed: 8035839
Biol Psychiatry. 1996 Dec 1;40(11):1091-9
pubmed: 8931911
Hum Brain Mapp. 2010 Sep;31(9):1339-47
pubmed: 20839293
J Infect Dis. 2015 Oct 1;212(7):1011-3
pubmed: 25840442
J Pediatric Infect Dis Soc. 2018 Dec 26;7(suppl_2):S75-S78
pubmed: 30590622
Arch Neurol. 1997 Dec;54(12):1521-31
pubmed: 9400362
J Neurovirol. 1995 Mar;1(1):30-9
pubmed: 9222340
Lancet. 1988 May 14;1(8594):1065-7
pubmed: 2896909
Bone Marrow Transplant. 2007 Jun;39(11):705-9
pubmed: 17401392
Autism Res. 2019 May;12(5):802-805
pubmed: 30964233
J Infect Dis. 2015 Oct 1;212(7):1014-21
pubmed: 25840441
J Pediatr. 1989 Apr;114(4 Pt 1):535-9
pubmed: 2647944
J Med Virol. 2001 May;64(1):42-6
pubmed: 11285567
Clin Infect Dis. 2005 Apr 1;40(7):932-40
pubmed: 15824982
Blood. 2013 Jan 3;121(1):207-18
pubmed: 23152545
Clin Infect Dis. 2013 Sep;57(5):671-81
pubmed: 23723198
J Clin Virol. 2011 May;51(1):12-9
pubmed: 21376661
Bone Marrow Transplant. 2010 Jan;45(1):129-36
pubmed: 19465942
Neuroradiol J. 2017 Aug;30(4):318-323
pubmed: 28632041
Pediatrics. 1992 May;89(5 Pt 1):888-90
pubmed: 1315948
Blood. 2011 May 12;117(19):5243-9
pubmed: 21389320
J Virol Methods. 2008 Dec;154(1-2):223-5
pubmed: 18706448
Bone Marrow Transplant. 2015 Aug;50(8):1030-6
pubmed: 25915811
Epilepsia. 2012 Jul;53(7):e122-6
pubmed: 22554258
Pediatr Neurol. 2009 Nov;41(5):353-8
pubmed: 19818937
J Infect Dis. 2006 Jan 1;193(1):68-79
pubmed: 16323134
Arch Dis Child. 1992 Dec;67(12):1484-5
pubmed: 1336954
J Med Virol. 2016 Feb;88(2):319-23
pubmed: 26241219
Transpl Infect Dis. 2020 Feb;22(1):e13203
pubmed: 31650671
Biol Blood Marrow Transplant. 2012 Nov;18(11):1638-48
pubmed: 22564265
Pediatr Infect Dis J. 2015 Oct;34(10):1118-27
pubmed: 26132825
Bone Marrow Transplant. 2000 Dec;26(11):1193-7
pubmed: 11149730
Neurology. 2013 Apr 16;80(16):1494-500
pubmed: 23516318
Br J Haematol. 2005 Jan;128(1):66-72
pubmed: 15606551
Biol Blood Marrow Transplant. 2018 Nov;24(11):2324-2336
pubmed: 29684567
Neurology. 2007 Jul 10;69(2):156-65
pubmed: 17620548
Br J Haematol. 2000 Dec;111(3):774-81
pubmed: 11122137
Ann Neurol. 1993 Jun;33(6):597-603
pubmed: 8388679