Engineered Skin Substitute Regenerates the Skin with Hair Follicle Formation.
engineered skin substitute
hair follicle neogenesis
skin derived precursors
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
08 Apr 2021
08 Apr 2021
Historique:
received:
17
03
2021
revised:
04
04
2021
accepted:
06
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
Currently, engineered skin substitutes (ESS) are unable to regenerate cutaneous appendages. Recent studies have shown that skin-derived precursors (SKPs), which are extensively available, have the potential to induce hair follicle neogenesis. Here, we demonstrate that ESS consisting of culture-expanded SKPs and epidermal stem cells (Epi-SCs) reconstitute the skin with hair follicle regeneration after grafting into nude mice. SKPs seeded in a C-GAG matrix proliferated and expressed higher levels of hair induction signature genes-such as
Identifiants
pubmed: 33917746
pii: biomedicines9040400
doi: 10.3390/biomedicines9040400
pmc: PMC8068101
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Natural Science Foundation of China
ID : 31961160702, 81903239
Organisme : National Key R&D Program of China
ID : 2017YFC1103304
Organisme : Shenzhen Science and Technology Innovation Committee
ID : JCYJ20180307123901314, JCYJ20190809180217220 and JCYJ20180307123807944
Organisme : China Postdoctoral Science Foundation
ID : 2019M663673
Organisme : Tsinghua Shenzhen International Graduate School Overseas Cooperation Fund
ID : HW2018006
Organisme : State Key Laboratory of Chemical Oncogenomics fund
ID : State Key Laboratory of Chemical Oncogenomics fund
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