Infantile Brain Tumors: A Review of Literature and Future Perspectives.
brain tumors
congenital cancer
neonatal cancer
neuro-oncology
tumors in infants
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
08 Apr 2021
08 Apr 2021
Historique:
received:
15
03
2021
revised:
01
04
2021
accepted:
05
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
Brain tumors in infants including those diagnosed in fetal age, newborns and under a year old represent less than 10% of pediatric nervous system tumors and present differently when compared with older children in terms of clinical traits, location and histology. The most frequent clinical finding is a macrocephaly but non-specific symptoms can also be associated. The prognosis is usually poor and depends on several factors. Surgery continues to be the main option in terms of therapeutic strategies whereas the role of chemotherapy is not yet well defined and radiotherapy is exceptionally undertaken. In view of this situation, a molecular characterization could assist in providing therapeutic options for these tumors. This review highlights the recent advances in the diagnosis and treatment of brain tumors in infants with a particular focus on the molecular landscape and future clinical applications.
Identifiants
pubmed: 33917833
pii: diagnostics11040670
doi: 10.3390/diagnostics11040670
pmc: PMC8068230
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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