Liposomes as Antibiotic Delivery Systems: A Promising Nanotechnological Strategy against Antimicrobial Resistance.
antibiotic
antimicrobial resistance
bacterial infection
liposome
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
02 Apr 2021
02 Apr 2021
Historique:
received:
13
03
2021
revised:
30
03
2021
accepted:
31
03
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
14
5
2021
Statut:
epublish
Résumé
Antimicrobial drugs are key tools to prevent and treat bacterial infections. Despite the early success of antibiotics, the current treatment of bacterial infections faces serious challenges due to the emergence and spread of resistant bacteria. Moreover, the decline of research and private investment in new antibiotics further aggravates this antibiotic crisis era. Overcoming the complexity of antimicrobial resistance must go beyond the search of new classes of antibiotics and include the development of alternative solutions. The evolution of nanomedicine has allowed the design of new drug delivery systems with improved therapeutic index for the incorporated compounds. One of the most promising strategies is their association to lipid-based delivery (nano)systems. A drug's encapsulation in liposomes has been demonstrated to increase its accumulation at the infection site, minimizing drug toxicity and protecting the antibiotic from peripheral degradation. In addition, liposomes may be designed to fuse with bacterial cells, holding the potential to overcome antimicrobial resistance and biofilm formation and constituting a promising solution for the treatment of potential fatal multidrug-resistant bacterial infections, such as methicillin resistant
Identifiants
pubmed: 33918529
pii: molecules26072047
doi: 10.3390/molecules26072047
pmc: PMC8038399
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Liposomes
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fundação para a Ciência e a Tecnologia
ID : UIDB/00276/2020
Organisme : Fundação para a Ciência e a Tecnologia
ID : UIDB/04138/2020
Organisme : Fundação para a Ciência e a Tecnologia
ID : UIDP/04138/2020
Organisme : Fundação para a Ciência e a Tecnologia
ID : DL57/2016/CP1438/CT0002
Organisme : Universidade de Lisboa
ID : BD/2018
Organisme : Phospholipid Research Center
ID : MMG-2021-092/1-1
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