Quantitative Methodologies to Dissect Immune Cell Mechanobiology.
biomechanics
force
immune response
mechanobiology
quantitative technology
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
09 04 2021
09 04 2021
Historique:
received:
28
02
2021
revised:
02
04
2021
accepted:
06
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
21
10
2021
Statut:
epublish
Résumé
Mechanobiology seeks to understand how cells integrate their biomechanics into their function and behavior. Unravelling the mechanisms underlying these mechanobiological processes is particularly important for immune cells in the context of the dynamic and complex tissue microenvironment. However, it remains largely unknown how cellular mechanical force generation and mechanical properties are regulated and integrated by immune cells, primarily due to a profound lack of technologies with sufficient sensitivity to quantify immune cell mechanics. In this review, we discuss the biological significance of mechanics for immune cells across length and time scales, and highlight several experimental methodologies for quantifying the mechanics of immune cells. Finally, we discuss the importance of quantifying the appropriate mechanical readout to accelerate insights into the mechanobiology of the immune response.
Identifiants
pubmed: 33918573
pii: cells10040851
doi: 10.3390/cells10040851
pmc: PMC8069647
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
ID : 212343
Pays : United Kingdom
Organisme : Engineering and Physical Sciences Research Council
ID : EP/S004459/1
Organisme : Wellcome Trust
ID : 212343/Z/18/Z
Pays : United Kingdom
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