Alcohol Consumption and Hepatitis C Virus (HCV) RNA Levels in HIV/HCV Coinfected Patients.
HCV RNA levels
HIV
alcohol
alcohol use disorder
chronic HCV infection
unhealthy alcohol use
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
21 04 2021
21 04 2021
Historique:
received:
31
01
2021
revised:
07
04
2021
accepted:
19
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
18
8
2021
Statut:
epublish
Résumé
The impact of Hepatitis C virus (HCV) RNA levels on the evolution of chronic HCV infection-related liver damage is controversial. Heavy alcohol use is believed to have a deleterious impact on the course of HCV disease, but current knowledge about the possible effect of alcohol use on HCV RNA levels in HIV/HCV coinfected patients is limited. We examined 107 HIV/HCV-infected individuals with current or past unhealthy alcohol use to assess the association between alcohol consumption (any drinking vs. abstinent) and HCV RNA levels. Participants were 75% male, with a mean age of 43 years, and 63% were on antiretroviral therapy. Mean (SD) log HIV RNA was 3.1 (1.4) and mean (SD) log HCV RNA was 6.1 (0.8). Past-month alcohol use was present in 38% of participants. In a multivariable linear regression analysis we found no significant differences in mean log HCV RNA levels between those reporting alcohol use and those who were abstinent [β (95%CI): -0.04 (-0.34, 0.26), We did not detect significant associations between alcohol use and HCV RNA levels among HIV/HCV coinfected patients.
Sections du résumé
BACKGROUND
The impact of Hepatitis C virus (HCV) RNA levels on the evolution of chronic HCV infection-related liver damage is controversial. Heavy alcohol use is believed to have a deleterious impact on the course of HCV disease, but current knowledge about the possible effect of alcohol use on HCV RNA levels in HIV/HCV coinfected patients is limited.
METHODS
We examined 107 HIV/HCV-infected individuals with current or past unhealthy alcohol use to assess the association between alcohol consumption (any drinking vs. abstinent) and HCV RNA levels.
RESULTS
Participants were 75% male, with a mean age of 43 years, and 63% were on antiretroviral therapy. Mean (SD) log HIV RNA was 3.1 (1.4) and mean (SD) log HCV RNA was 6.1 (0.8). Past-month alcohol use was present in 38% of participants. In a multivariable linear regression analysis we found no significant differences in mean log HCV RNA levels between those reporting alcohol use and those who were abstinent [β (95%CI): -0.04 (-0.34, 0.26),
CONCLUSIONS
We did not detect significant associations between alcohol use and HCV RNA levels among HIV/HCV coinfected patients.
Identifiants
pubmed: 33919027
pii: v13050716
doi: 10.3390/v13050716
pmc: PMC8142976
pii:
doi:
Substances chimiques
RNA, Viral
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAAA NIH HHS
ID : U24 AA020778
Pays : United States
Organisme : NIAAA NIH HHS
ID : U24 AA020779
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI042853
Pays : United States
Organisme : NIAAA NIH HHS
ID : K24 AA015674
Pays : United States
Références
Drug Alcohol Depend. 2006 May 20;82(3):231-7
pubmed: 16256278
Alcohol Clin Exp Res. 2006 Apr;30(4):709-19
pubmed: 16573590
AIDS. 2012 Jul 31;26(12):1509-16
pubmed: 22555162
Alcohol Clin Exp Res. 2006 Sep;30(9):1520-6
pubmed: 16930214
AIDS. 2012 Sep 24;26(15):1917-26
pubmed: 22781222
AIDS Care. 2007 Sep;19(8):1039-47
pubmed: 17852002
Lancet. 2011 Apr 2;377(9772):1198-209
pubmed: 21459211
J Hepatol. 2012 Feb;56(2):334-40
pubmed: 21756854
Res Virol. 1997 Jul-Aug;148(4):267-71
pubmed: 9272577
Alcohol Alcohol. 2000 May-Jun;35(3):296-301
pubmed: 10869251
JAMA. 2015 Mar 24-31;313(12):1223-31
pubmed: 25706092
J Community Health. 2008 Jun;33(3):126-33
pubmed: 18165889
AIDS. 2008 Jan 30;22(3):415-20
pubmed: 18195568
Drug Alcohol Depend. 2016 Dec 01;169:101-109
pubmed: 27810652
AIDS. 2000 Jan 28;14(2):212
pubmed: 10708298
Semin Liver Dis. 2009 May;29(2):188-99
pubmed: 19387918
AIDS Care. 2000 Jun;12(3):255-66
pubmed: 10928201
Drug Alcohol Depend. 1996 Sep;42(1):49-54
pubmed: 8889403
Curr HIV/AIDS Rep. 2010 Nov;7(4):226-33
pubmed: 20814765
Alcohol Clin Exp Res. 2004 Apr;28(4):572-7
pubmed: 15100608
J Acquir Immune Defic Syndr. 2012 Oct 1;61(2):171-8
pubmed: 22820808
Hepatology. 2005 Dec;42(6):1446-52
pubmed: 16317675
Med Clin (Barc). 2012 May 19;138(14):627-32
pubmed: 21696783
PLoS One. 2011;6(11):e27436
pubmed: 22087316
Hepatology. 1999 Mar;29(3):904-7
pubmed: 10051496
N Engl J Med. 2018 Sep 27;379(13):1251-1261
pubmed: 30257164
AIDS. 2013 Oct 23;27(16):2559-66
pubmed: 23770493
Hepatology. 2009 Apr;49(4):1335-74
pubmed: 19330875
J Hepatol. 2001 May;34(5):730-9
pubmed: 11434620
Am J Epidemiol. 1997 Dec 1;146(11):975-81
pubmed: 9400340
Hepatology. 1998 Jun;27(6):1717-22
pubmed: 9620348
Clin Infect Dis. 2005 Jul 1;41 Suppl 1:S105-9
pubmed: 16265607
Semin Liver Dis. 2004;24 Suppl 2:3-8
pubmed: 15346240
Nature. 2009 Oct 8;461(7265):798-801
pubmed: 19759533
J Acquir Immune Defic Syndr. 2007 Oct 1;46(2):194-9
pubmed: 17667330
Antivir Ther. 2003 Oct;8(5):365-72
pubmed: 14640382
Gut. 2005 Oct;54(10):1468-72
pubmed: 16162952
J Acquir Immune Defic Syndr. 2009 Oct 1;52(2):180-202
pubmed: 19668086
HIV Med. 2008 Apr;9(4):196-202
pubmed: 18366443
Med Care. 2005 Jun;43(6):574-85
pubmed: 15908852
J Acquir Immune Defic Syndr. 2006 Dec 1;43(4):411-7
pubmed: 17099312
Clin Gastroenterol Hepatol. 2005 Nov;3(11):1150-9
pubmed: 16271348
World J Gastroenterol. 2007 May 7;13(17):2436-41
pubmed: 17552026
J Acquir Immune Defic Syndr. 2006 Apr 1;41(4):471-6
pubmed: 16652056
Dig Dis Sci. 2001 Aug;46(8):1677-83
pubmed: 11508667