Nusinersen Modulates Proteomics Profiles of Cerebrospinal Fluid in Spinal Muscular Atrophy Type 1 Patients.

Child, Preschool Female Genetic Therapy Humans Infant Male Oligonucleotides / pharmacology Oligonucleotides, Antisense / pharmacology Proteome / analysis Spinal Muscular Atrophies of Childhood / cerebrospinal fluid
ASO apolipoprotein A1 apolipoprotein E carbonyl groups haptoglobin neuromuscular disease nusinersen oxidized proteins spinal muscular atrophy type 1 survival motor neuron (SMN) transthyretin

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
21 Apr 2021
Historique:
received: 01 04 2021
accepted: 19 04 2021
entrez: 30 4 2021
pubmed: 1 5 2021
medline: 20 5 2021
Statut: epublish

Résumé

Spinal muscular atrophy (SMA) type 1 is a severe infantile autosomal-recessive neuromuscular disorder caused by a survival motor neuron 1 gene (

Identifiants

DOI: 10.3390/ijms22094329 PMID: 33919289 PMC: PMC8122268
pubmed: 33919289
pii: ijms22094329
doi: 10.3390/ijms22094329
pmc: PMC8122268
pii:
doi:

Substances chimiques

Oligonucleotides 0
Oligonucleotides, Antisense 0
Proteome 0
nusinersen 5Z9SP3X666

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Références

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Auteurs

Laura Bianchi (L)

Functional Proteomics Laboratory, Department of Life Sciences, University of Siena, 53100 Siena, Italy.
ORCID: 0000-0001-9219-1227

Maria Sframeli (M)

Nemo Sud Clinical Centre, 98125 Messina, Italy.

Lorenza Vantaggiato (L)

Functional Proteomics Laboratory, Department of Life Sciences, University of Siena, 53100 Siena, Italy.

Gian Luca Vita (GL)

Nemo Sud Clinical Centre, 98125 Messina, Italy.

Annamaria Ciranni (A)

Unit of Neurology and Neuromuscular Diseases, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.

Francesca Polito (F)

Unit of Neurology and Neuromuscular Diseases, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.

Rosaria Oteri (R)

Unit of Neurology and Neuromuscular Diseases, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.

Eloisa Gitto (E)

Neonatal and Paediatric Intensive Care Unit, Department of Human Pathology in Adult and Developmental Age, University of Messina, 98125 Messina, Italy.

Fabrizio Di Giuseppe (F)

Dentistry and Biotechnology, and Proteomics Unit, Centre of Advanced Studies and Technoloy, Department Medical, Oral & Biotechnological Sciences, "G. d'Annunzio", University of Chieti-Pescara, 66100 Chieti, Italy.

Stefania Angelucci (S)

Dentistry and Biotechnology, and Proteomics Unit, Centre of Advanced Studies and Technoloy, Department Medical, Oral & Biotechnological Sciences, "G. d'Annunzio", University of Chieti-Pescara, 66100 Chieti, Italy.

Antonio Versaci (A)

Intensive Care Unit, AOU Policlinico "G. Martino", 98125 Messina, Italy.

Sonia Messina (S)

Unit of Neurology and Neuromuscular Diseases, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.
ORCID: 0000-0001-7994-3391

Giuseppe Vita (G)

Nemo Sud Clinical Centre, 98125 Messina, Italy.
Unit of Neurology and Neuromuscular Diseases, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.

Luca Bini (L)

Functional Proteomics Laboratory, Department of Life Sciences, University of Siena, 53100 Siena, Italy.
ORCID: 0000-0001-8951-2106

M'hammed Aguennouz (M)

Unit of Neurology and Neuromuscular Diseases, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.
ORCID: 0000-0003-0440-0354

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Nusinersen Modulates Proteomics Profiles of...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génie génétique › Thérapie génétique › Nusinersen Modulates Proteomics Profiles of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Nusinersen Modulates Proteomics Profiles of...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nusinersen Modulates Proteomics Profiles of...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Polynucléotides › Oligonucléotides › Nusinersen Modulates Proteomics Profiles of...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Sondes moléculaires › Sondes d'acide nucléique › Éléments antisens (génétique) › Oligonucléotides antisens › Nusinersen Modulates Proteomics Profiles of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéome › Nusinersen Modulates Proteomics Profiles of...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Maladies neurodégénératives héréditaires › Amyotrophies spinales infantiles › Nusinersen Modulates Proteomics Profiles of...