Longitudinal Analysis and Comparison of Six Serological Assays up to Eight Months Post-COVID-19 Diagnosis.
COVID-19
SARS-CoV-2
assay performance
serological assays
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
21 Apr 2021
21 Apr 2021
Historique:
received:
26
02
2021
revised:
09
04
2021
accepted:
20
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
There is much data available concerning the initiation of the immune response after SARS-CoV-2 infection, but long-term data are scarce. We thus longitudinally evaluated and compared the total and neutralizing immune response of 61 patients to SARS-CoV-2 infection up to eight months after diagnosis by RT-PCR using several commercial assays. Among the 208 samples tested, the percentage of seropositivity was comparable between assays up to four months after diagnosis and then tended to be more heterogeneous between assays ( In conclusion, serological tests show equivalent sensitivity in the first months after the diagnosis of SARS-CoV-2 infection, but their performance later, postinfection, must be considered when interpreting the results.
Sections du résumé
BACKGROUND
BACKGROUND
There is much data available concerning the initiation of the immune response after SARS-CoV-2 infection, but long-term data are scarce.
METHODS
METHODS
We thus longitudinally evaluated and compared the total and neutralizing immune response of 61 patients to SARS-CoV-2 infection up to eight months after diagnosis by RT-PCR using several commercial assays.
RESULTS
RESULTS
Among the 208 samples tested, the percentage of seropositivity was comparable between assays up to four months after diagnosis and then tended to be more heterogeneous between assays (
CONCLUSIONS
CONCLUSIONS
In conclusion, serological tests show equivalent sensitivity in the first months after the diagnosis of SARS-CoV-2 infection, but their performance later, postinfection, must be considered when interpreting the results.
Identifiants
pubmed: 33919328
pii: jcm10091815
doi: 10.3390/jcm10091815
pmc: PMC8122444
pii:
doi:
Types de publication
Journal Article
Langues
eng
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