Regulatory Role of Nrf2 Signaling Pathway in Wound Healing Process.
Animals
Apoptosis
Autophagy
Biomarkers
Cell Movement
Cell Proliferation
Cytoprotection
/ genetics
Gene Expression Regulation
Humans
NF-E2-Related Factor 2
/ metabolism
Oxidation-Reduction
Oxidative Stress
Reactive Oxygen Species
/ metabolism
Signal Transduction
Skin
/ metabolism
Wound Healing
/ physiology
Nrf2
antioxidant
inflammation
skin
wound healing
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
21 Apr 2021
21 Apr 2021
Historique:
received:
21
03
2021
revised:
14
04
2021
accepted:
20
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
27
5
2021
Statut:
epublish
Résumé
Wound healing involves a series of cellular events in damaged cells and tissues initiated with hemostasis and finally culminating with the formation of a fibrin clot. However, delay in the normal wound healing process during pathological conditions due to reactive oxygen species, inflammation and immune suppression at the wound site represents a medical challenge. So far, many therapeutic strategies have been developed to improve cellular homeostasis and chronic wounds in order to accelerate wound repair. In this context, the role of Nuclear factor erythroid 2-related factor 2 (Nrf2) during the wound healing process has been a stimulating research topic for therapeutic perspectives. Nrf2 is the main regulator of intracellular redox homeostasis. It increases cytoprotective gene expression and the antioxidant capacity of mammalian cells. It has been reported that some bioactive compounds attenuate cellular stress and thus accelerate cell proliferation, neovascularization and repair of damaged tissues by promoting Nrf2 activation. This review highlights the importance of the Nrf2 signaling pathway in wound healing strategies and the role of bioactive compounds that support wound repair through the modulation of this crucial transcription factor.
Identifiants
pubmed: 33919399
pii: molecules26092424
doi: 10.3390/molecules26092424
pmc: PMC8122529
pii:
doi:
Substances chimiques
Biomarkers
0
NF-E2-Related Factor 2
0
Reactive Oxygen Species
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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