The Role of Polymeric Coatings for a Safe-by-Design Development of Biomedical Gold Nanoparticles Assessed in Zebrafish Embryo.
FET
gold nanoparticles
polymeric-coating
safe-by-design
toxicity
zebrafish
Journal
Nanomaterials (Basel, Switzerland)
ISSN: 2079-4991
Titre abrégé: Nanomaterials (Basel)
Pays: Switzerland
ID NLM: 101610216
Informations de publication
Date de publication:
14 Apr 2021
14 Apr 2021
Historique:
received:
08
03
2021
revised:
07
04
2021
accepted:
08
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
In the biomedical field, gold nanoparticles (GNPs) have attracted the attention of the scientific community thanks to their high potential in both diagnostic and therapeutic applications. The extensive use of GNPs led researchers to investigate their toxicity, identifying stability, size, shape, and surface charge as key properties determining their impact on biological systems, with possible strategies defined to reduce it according to a Safe-by-Design (SbD) approach. The purpose of the present work was to analyze the toxicity of GNPs of various sizes and with different coating polymers on the developing vertebrate model, zebrafish. In particular, increasing concentrations (from 0.001 to 1 nM) of 6 or 15 nm poly-(isobutylene-alt-maleic anhydride)-
Identifiants
pubmed: 33919768
pii: nano11041004
doi: 10.3390/nano11041004
pmc: PMC8070688
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : Dipartimenti di Eccellenza 2017" - University of Milano Bicocca, Department of Biotechnology and Biosciences
Organisme : Horizon 2020 Framework Programme
ID : 720851 PROTECT
Références
ACS Nano. 2012 Jul 24;6(7):5767-83
pubmed: 22659047
PLoS One. 2011;6(9):e24374
pubmed: 21931696
Materials (Basel). 2018 Jul 06;11(7):
pubmed: 29986436
ACS Nano. 2011 Jun 28;5(6):4688-97
pubmed: 21609003
Nano Today. 2011 Dec;6(6):585-607
pubmed: 23293661
Chem Phys Lett. 2010 Feb 25;487(1-3):
pubmed: 24187379
Trends Biotechnol. 2019 Sep;37(9):995-1010
pubmed: 30862388
Nanotoxicology. 2011 Mar;5(1):43-54
pubmed: 21417687
J Nanobiotechnology. 2016 Aug 20;14(1):65
pubmed: 27544212
Small. 2013 May 27;9(9-10):1608-18
pubmed: 23208995
Part Fibre Toxicol. 2017 Apr 21;14(1):13
pubmed: 28431555
Nanomaterials (Basel). 2020 Apr 20;10(4):
pubmed: 32325941
Nanomaterials (Basel). 2015 Aug 27;5(3):1418-1430
pubmed: 28347072
Nanoscale. 2015 Oct 14;7(38):15553-67
pubmed: 26360607
Sci Rep. 2017 Jun 26;7(1):4239
pubmed: 28652584
Zygote. 1996 May;4(2):101-8
pubmed: 8913023
Reprod Toxicol. 2015 Aug 1;55:3-10
pubmed: 25261610
EMBO Rep. 2017 Jan;18(1):1-2
pubmed: 27979973
Front Bioeng Biotechnol. 2020 Apr 02;8:258
pubmed: 32300587
Sci Rep. 2017 Mar 28;7:45292
pubmed: 28349970
J Nanopart Res. 2010 Sep;12(7):2313-2333
pubmed: 21170131
Angew Chem Int Ed Engl. 2011 Feb 25;50(9):1980-94
pubmed: 21275011
Small. 2007 Nov;3(11):1941-9
pubmed: 17963284
Adv Drug Deliv Rev. 2016 Apr 1;99(Pt A):28-51
pubmed: 26456916
Aquat Toxicol. 2017 Apr;185:1-10
pubmed: 28142078
Chem Commun (Camb). 2020 Sep 29;56(77):11398-11401
pubmed: 32990290
J Biomed Nanotechnol. 2014 Jun;10(6):1004-15
pubmed: 24749395
Adv Sci (Weinh). 2020 May 17;7(13):2000406
pubmed: 32670765
Toxicol Appl Pharmacol. 2009 Apr 1;236(1):16-24
pubmed: 19162059
Int J Nanomedicine. 2011;6:2071-81
pubmed: 21976982
Int J Toxicol. 2019 Sep/Oct;38(5):357-384
pubmed: 31462100
Colloids Surf B Biointerfaces. 2014 Nov 1;123:900-6
pubmed: 25466455
Toxicol Sci. 2013 Jun;133(2):275-88
pubmed: 23549158
Nanotechnology. 2010 Apr 9;21(14):145101
pubmed: 20220222
J Appl Toxicol. 2018 Aug;38(8):1153-1161
pubmed: 29656436